Jun Gu
Shanghai Jiao Tong University
Internal medicineEndocrinologyCardiologyRandomized controlled trialProspective cohort studyClinical endpointSinus rhythmCatheter ablationHeart failure with preserved ejection fractionAblationAtrial fibrillationAtrial tachycardiaBody mass indexCTGFPulmonary veinAngiotensin IIPersistent atrial fibrillationIn patientIncidence (epidemiology)Cancer researchProportional hazards modelRisk factorSignal transductionMedicinePharmacology
26Publications
15H-index
471Citations
Publications 28
Newest
#1Hongbing Xiao (Fudan University)
#2Wei Hu (Fudan University)
Last. Dandan Li (Fudan University)
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#1Jun GuH-Index: 6
#2Jian-an PanH-Index: 4
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#1Jun Gu (SJTU: Shanghai Jiao Tong University)H-Index: 15
#2Yuqi Fan (SJTU: Shanghai Jiao Tong University)H-Index: 13
Last. Changqian Wang (SJTU: Shanghai Jiao Tong University)H-Index: 23
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: The objective of the present study was to evaluate clinical implications of serum uric acid (UA) on the progression of heart failure with preserved ejection fraction (HFpEF) in hypertensive patients. A total of 1009 adult patients with left ventricular hypertrophy and suspected left ventricular diastolic dysfunction were enrolled at our hospital from January 2008 to December 2011. With a median follow-up of 7.2 years, 136 (13.2%) patients developed new-onset HFpEF and 151 (15.0%) had major adv...
15 CitationsSource
#1Jun Gu (SJTU: Shanghai Jiao Tong University)H-Index: 15
#2Yu Qi FanH-Index: 1
Last. Chang Qian Wang (SJTU: Shanghai Jiao Tong University)H-Index: 2
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OBJECTIVE: It is well known that patients with type 2 diabetes mellitus (T2DM) have a high risk of atrial fibrillation (AF). The current study was designed to determine the relationship between long-term glycemic variability and incidence of new-onset AF in T2DM patients. METHODS: Between January 2008 and December 2009, we conducted a retrospective cohort study in patients with T2DM referred to our hospital. In 505 consecutive patients without any medical history of AF at baseline, the relations...
14 CitationsSource
#1Jun Gu (SJTU: Shanghai Jiao Tong University)H-Index: 15
#2Yuqi Fan (SJTU: Shanghai Jiao Tong University)H-Index: 13
Last. Changqian Wang (SJTU: Shanghai Jiao Tong University)H-Index: 23
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Abstract Background This study aimed to investigate the association between variability in hemoglobin A1c (HbA1c) and left ventricular (LV) diastolic function and incidence of symptomatic heart failure with preserved ejection fraction (HFpEF) in patients with type 2 diabetes mellitus (T2DM) and arterial hypertension. Methods A retrospective cohort study was conducted on eligible patients with T2DM and hypertension and without clinical signs or symptoms of heart failure in our hospital medical re...
18 CitationsSource
#1Tingquan Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Zhihua HanH-Index: 14
Last. Changqian WangH-Index: 23
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// Tingquan Zhou 1, * , Zhihua Han 1, * , Jun Gu 1 , Shaojie Chen 2 , Yuqi Fan 1 , Huili Zhang 1 , Yuehui Yin 3 , Junfeng Zhang 1 and Changqian Wang 1 1 Department of Cardiology, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China 2 Department of Cardiology, Shanghai First People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China 3 Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Cho...
7 CitationsSource
#1Jun Gu (SJTU: Shanghai Jiao Tong University)H-Index: 15
#2Yuqi Fan (SJTU: Shanghai Jiao Tong University)H-Index: 13
Last. Changqian Wang (SJTU: Shanghai Jiao Tong University)H-Index: 23
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Abstract Background Hypertension complicated with left ventricular hypertrophy (LVH) and diastolic dysfunction is independently related to increasing risk of subsequent incident heart failure with preserved ejection fraction (HFpEF). This study was designed to evaluate the influences of long-term aldosterone antagonist prescription in these patients. Methods Using a propensity score matching of 1:2 ratio, this retrospective claims database study compared spironolactone prescription (n=65) and no...
13 CitationsSource
#1Jun Gu (SJTU: Shanghai Jiao Tong University)H-Index: 15
#2Wei Hu (Fudan University)H-Index: 4
Last. Chang-qian Wang (SJTU: Shanghai Jiao Tong University)H-Index: 2
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Rapamycin, also known as sirolimus, is an antifungal agent and immunosuppressant drug used to prevent organ rejection in transplantation. However, little is known about the role of rapamycin in cardiac hypertrophy and the signaling pathways involved. Here, the effect of rapamycin was examined using phenylephrine (PE) induced cardiomyocyte hypertrophy in vitro and in a rat model of aortic banding (AB)-induced hypertrophy in vivo. Inhibition of MEK/ERK signaling reversed the effect of rapamycin on...
45 CitationsSource
Abstract Although hypertension (HTN), obstructive sleep apnea (OSA), and obesity frequently co–occur, the precise role of obesity in this interrelationship is not completely understood. A total of 727 OSA patients were assigned to body mass index (BMI) n = 201), 25≤ BMI n = 388), and BMI ≥30 (19%; n = 138). HTN risk factors in each group were evaluated. A total of 244 (33.6%) patients exhibited co–morbid HTN, of whom 20.5% (50/244), 52.9% (129/244), and 26.6% (65/244) were distributed between th...
3 CitationsSource