Vivek K. Kashyap
The University of Texas Rio Grande Valley
CancerEndoplasmic reticulumChemistryApoptosisIn vitroIn vivoOrmeloxifenePaclitaxelCervical cancerPancaMetastasisProstate cancerPancreatic cancerDocetaxelCell cycleCancer researchCell growthMedicineCell biologyCancer cell
40Publications
8H-index
240Citations
Publications 36
Newest
#1Sudhir Kotnala (The University of Texas Rio Grande Valley)H-Index: 1
#2Anupam Dhasmana (The University of Texas Rio Grande Valley)H-Index: 1
Last. Meena Jaggi (University of Texas at Austin)H-Index: 36
view all 6 authors...
Cystic fibrosis (CF) is an autosomal recessive disease which involves the mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CF involves the inflammatory processes and is considered as a multisystem disorder that is not confined to lungs, but it also affects other vital organs that leads to numerous co-morbidities. The respiratory disorder in the CF results in mortality and morbidity which is characterized by series of serious events involving mucus hypersecretion,...
1 CitationsSource
#1Vivek K. Kashyap (University of Texas at Austin)H-Index: 8
#2Anupam Dhasmana (University of Texas at Austin)H-Index: 7
Last. Meena Jaggi (University of Texas at Austin)H-Index: 36
view all 5 authors...
2 CitationsSource
#1Vivek K. KashyapH-Index: 8
#2Anupam Dhasmana (University of Texas at Austin)H-Index: 7
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
view all 8 authors...
The coronavirus disease 2019 (COVID-19) pandemic, an infection caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), has led to more than 771,000 deaths worldwide. Tobacco smoking is a major known risk factor for severe illness and even death from many respiratory infections. The effects of smoking on COVID-19 are currently controversial. Here, we provide an overview of the current knowledge on the effects of smoking on the clinical manifestations, disease progression, inflam...
17 CitationsSource
#1Anupam Dhasmana (The University of Texas Rio Grande Valley)H-Index: 1
#2Vivek K. Kashyap (The University of Texas Rio Grande Valley)H-Index: 8
Last. Subhash C. Chauhan (The University of Texas Rio Grande Valley)H-Index: 49
view all 9 authors...
Previously human society has faced various unprecedented pandemics in the history and viruses have majorly held the responsibilities of those outbreaks. Furthermore, due to amplified global connection and speedy modernization, epidemic outbreaks caused by novel and re­emergingviruses signify potential risk to community health. Despite, great advancements in immunization and drug discovery processes, still various viruses lack prophylactic vaccines and efficient antiviral therapies. Although, vac...
1 CitationsSource
#1Anupam Dhasmana (University of Texas at Austin)H-Index: 7
#2Swati Uniyal (Gautam Buddha University)H-Index: 3
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
view all 11 authors...
Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regulatory action on protein interaction network (PIN), an interectome was created based on 788 key proteins, extracted from PubMed literatures, and constructed by using STRING and Cytoscape programs. The ...
3 CitationsSource
#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#2Nirnoy Dan (UTHSC: University of Tennessee Health Science Center)H-Index: 6
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 49
view all 14 authors...
Abstract In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the ...
3 CitationsSource
#1Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
#2Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 9 authors...
Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation. However, few studies were available that addressed the topic of targeting lipid metabolism in PCa. Here, we assessed the tannic acid (TA) lipid-targeting ability and its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) in PCa cells. TA exhibited dual effects by inhibiting lipog...
10 CitationsSource
#1Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
#2Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 11 authors...
Cellular senescence is one of the prevailing issues in cancer therapeutics that promotes cancer relapse, chemoresistance, and recurrence. Patients undergoing persistent chemotherapy often develop drug-induced senescence. Docetaxel, an FDA-approved treatment for prostate cancer, is known to induce cellular senescence which often limits the overall survival of patients. Strategic therapies that counter the cellular and drug-induced senescence are an unmet clinical need. Towards this an effort was ...
10 CitationsSource
#1Brahm S. SrivastavaH-Index: 24
#2Vipul K. Singh (Houston Methodist Hospital)H-Index: 10
Last. Chinnaswamy Jagannath (Houston Methodist Hospital)H-Index: 34
view all 6 authors...
Source
#1Andrew E. Massey (UT: University of Tennessee)H-Index: 5
#2Mohammed Sikander (UT: University of Tennessee)H-Index: 7
Last. Subhash C. Chauhan (UT: University of Tennessee)H-Index: 49
view all 13 authors...
Abstract Pancreatic cancer (PanCa) is a major cause of cancer-related death due to limited therapeutic options. As pancreatic tumors are highly desmoplastic, they prevent appropriate uptake of therapeutic payloads. Thus, our objective is to develop a next-generation nanoparticle system for treating PanCa. We generated a multi-layered Pluronic F127 and polyvinyl alcohol stabilized and poly-L-lysine coated paclitaxel loaded poly(lactic-co-glycolic acid) nanoparticle formulation (PPNPs). This formu...
7 CitationsSource