Takumi Oti
Kanagawa University
Sexual dimorphismNeuropeptideEndocrinologyNeuroscienceReceptorOxytocin receptorOxytocinVasopressinGastrin-releasing peptideHypothalamusNeuromedin BEjaculationAndrogenBombesinSpinal cordLumbar Spinal CordCentral nervous systemMedicineBiologyCell biology
20Publications
6H-index
103Citations
Publications 19
Newest
#1Takumi Oti (Kanagawa University)H-Index: 6
#2Tatsuya Sakamoto (Okayama University)H-Index: 26
Last. Hirotaka Sakamoto (Okayama University)H-Index: 28
view all 3 authors...
Oxytocin is produced in the hypothalamus and stimulates uterine contraction and milk ejection. While many people consider oxytocin to be a female hormone, it is reported that, in men, the plasma ox...
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The spinal ejaculation generator (SEG) is located in the central gray (lamina X) of the rat lumbar spinal cord and plays a pivotal role in the ejaculatory reflex. We recently reported that SEG neurons express the oxytocin receptor and are activated by oxytocin projections from the paraventricular nucleus of hypothalamus (PVH). However, it is unknown whether the SEG responds to oxytocin in vivo. In this study, we analyzed the characteristics of the brain–spinal cord neural circuit that controls m...
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#1Takumi Oti (Kanagawa University)H-Index: 6
#2Keita Satoh (Okayama University)H-Index: 7
Last. Hirotaka Sakamoto (University of Oxford)H-Index: 28
view all 12 authors...
Summary Oxytocinergic neurons in the paraventricular nucleus of the hypothalamus that project to extrahypothalamic brain areas and the lumbar spinal cord play an important role in the control of erectile function and male sexual behavior in mammals. The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord is an important component of the neural circuits that control penile reflexes in rats, circuits that are commonly referred to as the “spinal ejaculation generator (SEG).” We ha...
3 CitationsSource
#1Yuta Kohro (Kyushu University)H-Index: 11
#2Tsuyoshi Matsuda (Kyushu University)H-Index: 5
Last. Makoto Tsuda (Kyushu University)H-Index: 51
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Astrocytes are critical regulators of CNS function and are proposed to be heterogeneous in the developing brain and spinal cord. Here we identify a population of astrocytes located in the superficial laminae of the spinal dorsal horn (SDH) in adults that is genetically defined by Hes5. In vivo imaging revealed that noxious stimulation by intraplantar capsaicin injection activated Hes5+ SDH astrocytes via α1A-adrenoceptors (α1A-ARs) through descending noradrenergic signaling from the locus coerul...
5 CitationsSource
#1Natsuko Kawakami (University of Oxford)H-Index: 1
#2Akito Otubo (Okayama University)
Last. Hirotaka Sakamoto (University of Oxford)H-Index: 28
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#1Asuka Hirooka (Okayama University)H-Index: 1
#2Mayuko Hamada (Okayama University)H-Index: 14
Last. Hirotaka Sakamoto (Okayama University)H-Index: 28
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Gastrin-releasing peptide (GRP), first isolated from the porcine stomach, is a neuropeptide that modulates the autonomic system in mammals and has previously been considered to be the mammalian equivalent of bombesin, a fourteen amino acid peptide first isolated from the skin of the European fire-bellied toad, Bombina bombina . Bombesin-like peptides and the related neuromedin B (NMB) have since been identified in mammals. However, the orthologous relationships among GRP/NMB/bombesin and their r...
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#1Takumi Oti (Okayama University)H-Index: 6
#2Keita Satoh (Okayama University)H-Index: 7
Last. Hirotaka Sakamoto (Okayama University)H-Index: 28
view all 11 authors...
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#1Manami Kamishima (Meiji University)H-Index: 1
#2Tatsuya Hattori (Meiji University)H-Index: 2
Last. Maiko Kawaguchi (Meiji University)H-Index: 11
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: Exposure to endocrine-disrupting chemicals may adversely affect animals, particularly during development. Tris(1,3-dichloroisopropyl) phosphate (TDCIPP) is an organophosphate with anti-androgen function in vitro that is present in indoor dust at relatively high concentrations. In male rats, androgens are necessary for the development of reproductive organs, as well as the endocrine and central nervous systems. However, we currently do not know the exact effects of TDCIPP exposure through suckl...
4 CitationsSource
#1Takumi Oti (Okayama University)H-Index: 6
#2Keiko Takanami (Kyoto Prefectural University of Medicine)H-Index: 10
Last. Hirotaka Sakamoto (Okayama University)H-Index: 28
view all 10 authors...
The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord controls male sexual function in rats. In contrast, in female rats, GRP neurons could scarcely be detected around puberty when circulating ovarian steroid hormones such as estradiol and progesterone levels are increasing. However, little information is available on feminizing or demasculinizing effects of ovarian steroids on the central nervous system in female puberty and adulthood. In this study, to visualize the spinal ...
1 CitationsSource
#1T. Ito (Okayama University)H-Index: 1
#2Takumi Oti (Okayama University)H-Index: 6
Last. Hirotaka SakamotoH-Index: 28
view all 7 authors...
A sexually dimorphic peptidergic system in the lower spinal cord controlling penile function in non-human primates
2 CitationsSource