Yuanyuan Li
Northeastern University (China)
TriterpenoidCytotoxicityPhosphorylationAkt/PKB signaling pathwayChemical compositionMass spectrometryInhibitory postsynaptic potentialNutraceuticalChemistryGlycosideTwo-dimensional nuclear magnetic resonance spectroscopyIn vivoNeuroprotectionBerryOxidative stressHepatocyteDehydrogenaseWestern blotLiver injuryBacteroidetesInsulin resistanceFirmicutesAntioxidantDyslipidemiaPsidiumGallic acidPhloroglucinolAcetaminophenNerolidolStreptozotocinInsulinMaslinic acidUrsolic acidAnti-inflammatoryPancreatic isletsEthyl acetateGCLCFunctional foodAnemone chinensisProtein Tyrosine Phosphatase 1BMetabolism disorderStreptomyces scopuliridisStreptozocinData interpretationGlucose homeostasisAnti hyperglycaemicIc50 valuesHigh fat dietAnimal studyGut microbiomeSoluble extractFood scienceReactive oxygen speciesObesityp38 mitogen-activated protein kinasesGlutathioneGut floraBiochemistryDiabetes mellitusTraditional medicineMAPK/ERK pathwayOxidative phosphorylationMetabolismSignal transductionPolyphenolStereochemistryProtein kinase BBiologyNeuroinflammationPharmacology
10Publications
6H-index
123Citations
Publications 10
Newest
#1Zengguang Zhang (Northeastern University (China))H-Index: 1
#2Yuanyuan Li (Northeastern University (China))H-Index: 6
Last. Li Han (Northeastern University (China))H-Index: 12
view all 9 authors...
ABATRACTNine compounds, five phenolic glycosides (1, 2, 4-6), three phenylpropanoids (7-9), and a furanone glycoside (3), were isolated from aqueous soluble extract of the dried roots of Anemone chinensis Bunge. The structures of new compounds (1-4) were elucidated by comprehensive spectroscopic data analysis as well as chemical evidence. Pulsatillanin A (1) demonstrated significant antioxidant effects through scavenging free radical in DPPH assay, and relieved the oxidative stress in LPS-induce...
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#1Yuanyuan Li (NU: Northeastern University)H-Index: 6
#2Jialin Xu (NU: Northeastern University)H-Index: 5
Last. Liya Li (NU: Northeastern University)H-Index: 24
view all 8 authors...
Nutraceutical/pharmaceutical agents capable of maintaining redox and inflammation homeostasis are considered as candidates for the prevention and/or treatment of liver diseases. Psidium guajava (commonly known as guava) leaf is a commercially available functional food that has been reported to possess hepatoprotective property. However, the hepatoprotective constituents in guava leaf are not known. In the current study, a standardized triterpenoid-enriched extract of guava leaves (TGL) was devel...
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#1Yuanyuan LiH-Index: 6
#2Jialin XuH-Index: 5
Last. Liya LiH-Index: 24
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Benzophenone glycosides are a major type of polyphenols present in guava. To date, there is still poor understanding of the relationship between benzophenone glycosides and the hepatoprotective effects attributed to this edible fruit. Herein, the protective effects of guavinoside B (GUB), a main benzophenone glycoside present in guava fruit, against acetaminophen (APAP)-induced liver injury were investigated in vitro and in vivo. Fluorescence measurement demonstrated that GUB (at a concentration...
2 CitationsSource
#1Yuanyuan Li (NU: Northeastern University)H-Index: 6
#2Dongli Li (Wuyi University)H-Index: 11
Last. Liya Li (NU: Northeastern University)H-Index: 24
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Reactive oxygen species and subsequent oxidative stress are reported to play important roles in chronic metabolic diseases. Plant-derived polyphenols, especially food-derived phenolics, have attracted a lot of attention due to their potential usage against oxidative stress-related diseases. The leaf of Psidium guajava (known as guava) is regarded as a good resource of polyphenols and its products are commercially available in Japan as functional foods against multiple chronic metabolism disorder...
7 CitationsSource
#1Jialin Xu (NU: Northeastern University)H-Index: 5
#2Tingting Liu (NU: Northeastern University)H-Index: 3
Last. Liya Li (NU: Northeastern University)H-Index: 24
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SCOPE: Published data support that gut microbiota play an important role in the pathological process of obesity and related metabolic disorders. In the current study, it is investigated whether a standardized extract from Jamun (Eugenia jambolana), a widely consumed tropical fruit, could alleviate obesity and alter gut microbial community in high-fat diet (HFD)-fed mice. METHODS AND RESULTS: C57BL/6 mice are fed either a standard diet (SD) or HFD with or without Jamun fruit extract (JFE; 100 mg ...
20 CitationsSource
#1Jialin Xu (NU: Northeastern University)H-Index: 5
#2Tingting Liu (NU: Northeastern University)H-Index: 3
Last. Liya Li (NU: Northeastern University)H-Index: 24
view all 10 authors...
The edible berries of Eugenia jambolana Lam. (known as Jamun) are consumed in various parts of the world. Our previous studies revealed that a triterpenoid-enriched Jamun fruit extract (TJFE) showed beneficial effects on glucose homeostasis in non-diabetic mice. Herein, the anti-diabetic effects of TJFE (100 mg kg−1 by oral gavage for ten days) were evaluated in streptozotocin (STZ)-induced type 1 diabetic mice. TJFE significantly attenuated STZ-induced hyperglycemia and glucose intolerance, sup...
12 CitationsSource
#1Jialin Xu (NU: Northeastern University)H-Index: 5
#2Chunhui Yuan (NU: Northeastern University)H-Index: 4
Last. Liya LiH-Index: 24
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Emerging data suggest that urolithins, gut microbiota metabolites of ellagitannins, contribute toward multiple health benefits attributed to ellagitannin-rich foods, including walnuts, red raspberry, strawberry, and pomegranate. However, there is limited data on whether the potential neuroprotective effects of these ellagitannin-rich foods are mediated by urolithins. Herein, we evaluated the potential mechanisms of antineuroinflammatory effects of urolithins (urolithins A, B, and C; 8-methyl-O-u...
41 CitationsSource
#1Feifei Liu (NU: Northeastern University)H-Index: 5
#2Tao Yuan (CAS: Chinese Academy of Sciences)H-Index: 22
Last. Liya Li (NU: Northeastern University)H-Index: 24
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Fifteen new phloroglucinol derivatives, jamunones A–O (1–8 and 10–16, respectively), along with one known analogue spiralisone C (9), were isolated from Eugenia jambolana seeds. Their structures were elucidated by detailed nuclear magnetic resonance and mass spectrometry spectroscopic data interpretation. Compounds 1–9, 11, 12, and 14–16 inhibited protein tyrosine phosphatase 1B activity with IC50 values ranging from 0.42 to 3.2 μM.
16 CitationsSource
#1Yuanyuan Li (NU: Northeastern University)H-Index: 6
#2Jialin Xu (NU: Northeastern University)H-Index: 5
Last. Liya Li (NU: Northeastern University)H-Index: 24
view all 10 authors...
Abstract In our investigation of the anti-hyperglycaemic constituents of Eugenia jambolana L. (Jamun), one new triterpenoid, 2-O-cis-p-coumaroyl maslinic acid, along with thirteen known triterpenoids were isolated from the fruit ethyl acetate extract. The structures of compounds 1–14 were elucidated on the basis of mass spectrometry and nuclear magnetic resonance analyses. Animal studies demonstrated that the triterpenoid-enriched Jamun fruit extract (TJFE) decreased blood glucose content in C57...
20 CitationsSource
#1Liya Li (NU: Northeastern University)H-Index: 24
#2Ruohan Liu (NU: Northeastern University)H-Index: 1
Last. Xueshi Huang (NU: Northeastern University)H-Index: 9
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Two new nerolidol-type sesquiterpenes were isolated from the culture broth of Streptomyces scopuliridis, and identified based on 1D and 2D NMR spectroscopic data analyses.
1 CitationsSource