Qiushi Xu
Jilin University
FGF21Interleukin 6Internal medicineEndocrinologyLipolysisSurgeryWhite adipose tissueProinflammatory cytokineCarbohydrate metabolismAdipose tissueKinaseChemistryApoptosisMetabolic pathwayGlycolysisAutophagyEchogenicityGluconeogenesisStimulationLipid dropletSuperoxide dismutaseAbomasumOxidative stressAdipocyteSystemic inflammationKetosisInflammationAdipose triglyceride lipaseNFE2L2Mechanistic target of rapamycinMammary glandAntioxidantTransforming growth factor betaMalondialdehydeCytokineLipopolysaccharideGlutathione peroxidaseFatty liverIntercostal spaceAbdomenDisplacement (orthopedic surgery)Retinoic acidHormone-sensitive lipasePopulationPerilipin-1Abdomen wallLactate dehydrogenase ADairy industryPhysical examCellular homeostasisConfidence intervalLipid metabolismReactive oxygen speciesUltrasonographyTransfectionReceiver operating characteristicSignal transductionMedicineFibroblast growth factorBiomarker (medicine)IntracellularPI3K/AKT/mTOR pathwayBiologyMechanism (biology)Cell biologyPharmacologyCaspase
Publications 10
#1Fan Minghe (JLU: Jilin University)
#2Xiliang Du (JLU: Jilin University)H-Index: 12
Last. Wenwen Gao (JLU: Jilin University)H-Index: 5
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ABSTRACT Dairy cows with ketosis exhibit signs of pronounced adipose tissue lipolysis and systemic inflammation, both of which exacerbate this metabolic disorder. In nonruminants, CIDEC plays a pivotal role in the formation of large unilocular lipid droplets. The present study aimed to ascertain the role of CIDEC in the lipolytic and inflammatory response of white adipose tissue (WAT) in vivo and in vitro. Subcutaneous adipose tissue and blood samples were collected from 15 healthy cows (blood β...
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Guojin Li (JLU: Jilin University)H-Index: 2
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
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ABSTRACT Hyperketonemia is a metabolic disease in dairy cows, associated with negative nutrition balance (NNB) induced by low dry matter intake (DMI) and increased nutrient requirements. Hyperketonemia could induce metabolic stress, which might indirectly affect mammary tissue. Autophagy is a highly conserved physiological process that results in the turnover of intracellular material, and is involved in maintaining cellular homeostasis under the challenge of metabolic stress induced by NNB. The...
5 CitationsSource
#1Xudong SunH-Index: 7
#2Hongdou JiaH-Index: 7
Last. Chuang XuH-Index: 7
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During the transition into lactation, bovine mammary epithelial cells (bMECs) are likely subjected to altered redox balance due to the high metabolic rate associated with the onset of lactation. In non-ruminants, lycopene (LYC), a naturally occurring hydrocarbon carotenoid, has attracted considerable attention as a potential natural agent against oxidative stress. The aim of this study was to investigate whether LYC alleviates oxidative injury in bMECs induced by H2O2 and the underlying molecula...
15 CitationsSource
#1Qiushi Xu (JLU: Jilin University)H-Index: 6
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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: Ketosis is a major metabolic disorder of high-yielding dairy cows during the transition period. Although metabolic adaptations of the adipose tissue are critical for a successful transition, beyond lipolysis, alterations within adipose tissue during ketosis are not well known. The objective of this study was to investigate the adipose tissue proteome of healthy or ketotic postpartum cows to gain insights into biological adaptations that may contribute to disease outcomes. Adipose tissue biopsy...
6 CitationsSource
#1Xudong Sun (JLU: Jilin University)H-Index: 7
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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ABSTRACT Dairy cows with ketosis display excessive lipolysis in adipose tissue. Heat-shock protein B7 (HSPB7), a small heat-shock protein, plays important roles in mediating cytoprotective responses to oxidative stress in rodent adipose tissue. Accordingly, it is assumed that HSPB7 may also play important roles in the antioxidant response in adipose tissue of ketotic cows. Therefore, the aim of this study is to investigate (1) the redox state of adipose tissue in ketotic cows and (2) the role an...
10 CitationsSource
#1Qiushi Xu (JLU: Jilin University)H-Index: 6
#2Hongdou Jia (JLU: Jilin University)H-Index: 7
Last. Xiaobing Li (JLU: Jilin University)H-Index: 22
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Dairy cows with metabolic disorder in peripartal period display high inflammatory levels. Adipose tissue is a major endocrine organ, which is closely related to systemic inflammation. Retinoic acid (RA), an active metabolite of vitamin A, has shown potential therapeutic immunomodulatory properties. The objective of the study was to examine the effect of all-trans-RA (ATRA), the biologically most active metabolite of vitamin A, on lipopolysaccharide (LPS)-induced bovine adipocytes inflammatory re...
9 CitationsSource
#1Shiqi Zhang (JLU: Jilin University)H-Index: 2
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
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Dairy cows with ketosis displayed lipid metabolic disorder and high inflammatory levels. Adipose tissue is an active lipid metabolism and endocrine tissue and is closely related to lipid metabolism homeostasis and inflammation. Perilipin-1 (PLIN1), an adipocyte-specific lipid-coated protein, may be involved in the above physiological function. The aim of this study was to investigate the role of PLIN1 in lipid metabolism regulation and inflammatory factor synthesis in cow adipocytes. The results...
16 CitationsSource
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Qiushi Xu (JLU: Jilin University)H-Index: 6
Last. Xiaobing Li (JLU: Jilin University)H-Index: 22
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Background The natural incidence of left displacement of abomasum (LDA) in dairy cows was high. The diagnosis of LDA usually relies on characteristic physical exam findings but that transabdominal ultrasound is a useful technique that has been applied to the diagnosis of gastrointestinal diseases of dairy cows in equivocal cases.
3 CitationsSource
The objective of this study was to investigate the measurement of serum fibroblast growth factor-21 (FGF-21), a protein mainly synthesized by the liver, as a sensitive biomarker for diagnosis of ketosis in dairy cows. Ninety Holstein–Friesian dairy cows (60 healthy and 30 ketosis cases) were selected and divided into a Ketosis group (K), and a Control group (C). We measured serum FGF-21 and other biochemical parameters by commercial ELISA kits. In a combined population of all 90 cows, we found t...
11 CitationsSource
#1Chuang XuH-Index: 7
Last. Ziyang ZhangH-Index: 2
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Background Negative energy balance (NEB) is a common pathological foundation of ketosis and fatty liver. Liver and fat tissue are the major organs of lipid metabolism and take part in modulating lipid oxidative capacity and energy demands, which is also a key metabolic pathway that regulates NEB develop during perinatal period. Fibroblast growth factor-21 (FGF-21) is a recently discovered protein hormone that plays an important and specific regulating role in adipose lipid metabolism and liver g...
12 CitationsSource