Amol Sharma
Georgia Regents University
PathophysiologyInternal medicineRadiologyUrologySurgeryOncologyDemographyRandomized controlled trialIntensive care medicinePhysical therapyStimulationFecal incontinenceIrritable bowel syndromeParkinson's diseaseAnorectal manometryConstipationIn patientAnesthesiaGeneral surgeryMedicineGastroenterology
217Publications
19H-index
970Citations
Publications 116
Newest
#1Satish S.C. Rao (Georgia Regents University)H-Index: 79
#2Yun Yan (Georgia Regents University)H-Index: 4
Last. Shaheen Hamdy (University of Manchester)H-Index: 52
view all 6 authors...
OBJECTIVES Translumbosacral neuromodulation therapy (TNT) improves symptoms of fecal incontinence (FI), but its mechanism of action is unknown. We tested the hypothesis that TNT at one or more frequency will significantly improve underlying pathophysiology of FI through modulation of ascending and/or descending signaling pathways in the gut and brain axis and anorectal sensorimotor function. MATERIALS AND METHODS We assessed afferent anorectal-cortical evoked potentials (CEP) following electrica...
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#1Xuelian Xiang (Georgia Regents University)H-Index: 3
#2Amol Sharma (Georgia Regents University)H-Index: 19
Last. Satish S.C. Rao (Georgia Regents University)H-Index: 79
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BACKGROUND Biofeedback therapy is useful for treatment of fecal incontinence (FI), but is not widely available and labor intensive. We investigated if home biofeedback therapy (HBT) is non-inferior to office biofeedback therapy (OBT). METHODS Patients with FI (≥1 episode/week) were randomized to HBT or OBT for 6 weeks. HBT was performed daily using novel device that provided resistance training and electrical stimulation with voice-guided instructions. OBT consisted of six weekly sessions. Both ...
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#1Yun YanH-Index: 4
Last. Amol SharmaH-Index: 19
view all 5 authors...
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#1Amol Sharma (Georgia Regents University)H-Index: 19
#2Satish S.C. Rao (Georgia Regents University)H-Index: 79
Last. Waldman Sa (Thomas Jefferson University)
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BACKGROUND Chronic constipation is a common, heterogeneous disorder with multiple symptoms and pathophysiological mechanisms. Patients are often referred to a gastroenterology provider after laxatives fail. However, there is limited knowledge of the spectrum and management of constipation disorders. AIM To discuss the latest understanding of the spectrum of constipation disorders, tools for identifying a pathophysiologic-based diagnosis in the specialist setting, treatment options and the patien...
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#2Amol SharmaH-Index: 19
Last. Satish S.C. RaoH-Index: 79
view all 3 authors...
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#1Satish S.C. RaoH-Index: 79
#2Xuelian XiangH-Index: 3
Last. Shaheen Hamdy (University of Manchester)H-Index: 52
view all 8 authors...
Introduction Treatments for fecal incontinence (FI) remain unsatisfactory because they do not remedy the underlying multifactorial dysfunction(s) including anorectal neuropathy. The aim of this study was to investigate the optimal dose frequency, clinical effects, and safety of a novel treatment, translumbosacral neuromodulation therapy (TNT), aimed at improving neuropathy. Methods Patients with FI were randomized to receive 6 sessions of weekly TNT treatments consisting of 600 repetitive magnet...
3 CitationsSource
#1Tennekoon Karunaratne (Georgia Regents University)H-Index: 4
#2Chijioke Okereke (Georgia Regents University)H-Index: 1
Last. Amol Sharma (Georgia Regents University)H-Index: 19
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Dysbiosis is implicated by many studies in the pathogenesis of Parkinson’s disease (PD). Advances in sequencing technology and computing have resulted in confounding data regarding pathogenic bacterial profiles in conditions such as PD. Changes in the microbiome with reductions in short-chain fatty acid (SCFA)-producing bacteria and increases in endotoxin-producing bacteria likely contribute to the pathogenesis of PD. GPR109A, a G-protein coupled receptor found on the surface of the intestinal e...
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