Irene M. Wohlman
Rutgers University
ProdrugDownregulation and upregulationCannabinoid receptorMolecular biologyReceptorEnzymeKinaseChemistryPeroxisome proliferator-activated receptorTranscriptional regulationInflammationKeratinocyteNitrogen mustardMethylamineErythropoiesisAnti-inflammatoryAnandamideBone marrowNucleic acid metabolismBifunctionalSulfideSulfur mustardFatty acid amide hydrolaseNucleoside diphosphate kinase AMammalian embryologyPoison controlMouse skinEndocannabinoid systemBiochemistryDrug developmentMedicineMolecular pathologyIntracellularBiologyPharmacology
Publications 4
#1Carl Jeffrey Lacey (Lehigh University)H-Index: 4
#2Irene M. Wohlman (RU: Rutgers University)H-Index: 3
Last. Ned D. Heindel (Lehigh University)H-Index: 20
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The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug develo...
4 CitationsSource
#1Irene M. Wohlman (RU: Rutgers University)H-Index: 3
#2Gabriella M. Composto (RU: Rutgers University)H-Index: 5
Last. Jeffrey D. Laskin (RU: Rutgers University)H-Index: 69
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Vesicants including sulfur mustard (SM) and nitrogen mustard (NM) are bifunctional alkylating agents that cause skin inflammation, edema and blistering. This is associated with alterations in keratinocyte growth and differentiation. Endogenous cannabinoids, including N-arachidonoylethanolamine (anandamide, AEA) and 2-arachidonoyl glycerol (2-AG), are important in regulating inflammation, keratinocyte proliferation and wound healing. Their activity is mediated by binding to cannabinoid receptors ...
8 CitationsSource
#1Diane E. HeckH-Index: 38
#2Irene M. WohlmanH-Index: 3
Last. Jeffrey D. LaskinH-Index: 69
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Vesicants including sulfur mustard (SM, bis(2-chloroethyl) sulfide) and nitrogen mustard (NM, bis(2-chloroethyl)methylamine) are highly reactive bifunctional alkylating agents that target the skin....
#1Edith H. Postel (RU: Rutgers University)H-Index: 6
#2Irene M. Wohlman (RU: Rutgers University)H-Index: 3
Last. Krista M.D. La Perle (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
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The ubiquitously expressed nucleoside diphosphate kinases (Nm23/NDPK/Awd) are a large family of multifunctional enzymes implicated in nucleic acid metabolism and in normal and abnormal development. Here, we describe the generation and characterization of NDPK A- and B-deficient (Nme1−/−/Nme2−/−) mice in which >95% of the enzyme activity is eliminated. These mice are undersized, die perinatally, and exhibit a spectrum of hematological phenotypes including severe anemia, impaired maturation of ery...
35 CitationsSource