Fang Long
Nanjing University of Chinese Medicine
Therapeutic effectQuality of lifeMatrix (chemical analysis)PharmacodynamicsPharmacokineticsMonosaccharideInternal medicineOncologyGlycosidic bondMass spectrometryEndogenyRandomized controlled trialEnzymeChemistrySubgroup analysisElectrosprayIn vivoMetabolomicsCmaxGinsenosideChemotherapyBranPaeoniflorinDysbiosisIleumAmorphophallusSmall intestineChinese patent medicineCisplatinHerb-drug interactionsPathogenic bacteriaSulfonateGinsengBioactive compoundSystems pharmacologyXanthineDerivative (chemistry)Functional foodGlucomannanSulfur dioxideTriterpeneNauseaLinoleic acidVomitingFumigationSpleenIntestinal permeabilityHypoxanthineResidue (chemistry)Moutan cortexGinsenoside Rb1Liu-wei-di-huang wanMedicinal herbsChemical basisIntestinal absorptionChemical markerMass spectrometricPilot trialSerum pharmacochemistryIntestinal mucosaUplc esi qtof msFood supplementTandem mass spectrometryFood scienceChromatographySulfurGut floraBiochemistryMedicinePharmacology
10Publications
3H-index
27Citations
Publications 10
Newest
#1Wei Zhang (Nanjing University of Chinese Medicine)H-Index: 4
#2Weiwei Tao (Nanjing University of Chinese Medicine)H-Index: 21
Last. Qinan Wu (Nanjing University of Chinese Medicine)H-Index: 17
view all 11 authors...
By a pilot trial on investigating immunomodulatory activity and target of ginsenosides, the major bioactive components of ginseng, here we report that structural analogues in herbal medicines hit a shared target to achieve cumulative bioactivity. A ginsenoside analogues combination with definite immunomodulatory activity in vivo was designed by integrating pharmacodynamics, serum pharmacochemistry and pharmacokinetics approaches. The cumulative bioactivity of the ginsenoside analogues was valida...
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#1Ye-Ting Zou (Nanjing University of Chinese Medicine)H-Index: 3
#2Jing Zhou (Nanjing University of Chinese Medicine)H-Index: 8
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 9 authors...
Abstract Ethnopharmacological relevance Poria cocos (Schw.) Wolf (Poria) is a well-known traditional medicinal fungus. It has been considered to possess spleen-invigorating (Jianpi) effects in traditional Chinese medicine, and is used clinically to treat spleen deficiency (Pixu) with symptoms of intestinal disorders such as diarrhea, indigestion, mucositis and weight loss. The aim of this study To investigate the protective effects of Poria and its three component fractions (Water-soluble polysa...
1 CitationsSource
#1He Zhu (Nanjing University of Chinese Medicine)H-Index: 8
#2Hui Liu (Nanjing University of Chinese Medicine)
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 10 authors...
Chemotherapy is applied to treat non-small cell lung cancer (NSCLC), but often limited due to its unstable therapeutic effects and adverse reactions (ADRs). Ginseng and its main ingredients (ginsenosides and polysaccharides) have been clinically used as adjuvants to chemotherapy. However, their efficacies were based on individual trials with relatively small sample sizes, and it is difficult to draw a valid conclusion. In this study, eligible randomized controlled trials (RCTs) were searched in ...
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#1Cheng-Ying Wu (Nanjing University of Chinese Medicine)H-Index: 5
#2Jing ZhouH-Index: 8
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 8 authors...
In the present study, the hypoglycemic effects of glucomannan (AGM) and its enzyme-degraded products from Amorphophallus albus were investigated. Four degraded products were prepared through ultrafiltration of β-glucanase-degraded products of AGM. The hypoglycemic activities were evaluated in HFD-STZ-induced type 2 diabetes mellitus (T2DM) mice, and the diversity of gut bacteria was analyzed by 16S rRNA gene sequencing; the fecal short chain fatty acids (SCFAs) and endogenous metabolites were de...
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#1Ye-Ting Zou (Nanjing University of Chinese Medicine)H-Index: 3
#2Fang Long (Nanjing University of Chinese Medicine)H-Index: 3
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 8 authors...
INTRODUCTION: Triterpene acids from the dried sclerotia of Poria cocos (Schw.) Wolf (poria) were recently found to possess anti-cancer activities. Identification of more triterpene acid analogues in poria is worthwhile for high throughput screening in anti-cancer drug discovery. OBJECTIVE: To establish an efficient dereplication strategy for identifying triterpene acid analogues in poria based on ultra-performance liquid chromatography with electrospray ionisation quadrupole time-of-flight tande...
1 CitationsSource
#1Jing ZhouH-Index: 8
#1Jing Zhou (Peking Union Medical College)H-Index: 3
Last. Song-Lin LiH-Index: 26
view all 7 authors...
2 CitationsSource
#1Jing ZhouH-Index: 8
#1Jing Zhou (Peking Union Medical College)H-Index: 3
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 7 authors...
Abstract Ginseng is often prescribed together with cisplatin for treatment of cancer, but the interaction between ginseng and cisplatin is still unknown. This study employed ginsenoside Rb1 (Rb1), one of the major components in ginseng, to explore the effects and involved mechanisms of cisplatin on the pharmacokinetics of ginseng. The effects of cisplatin on the pharmacokinetics of Rb1 and its bioactive metabolites Rd, Rg3, and F2 were investigated by using A549-bearing mice with and without cis...
2 CitationsSource
#1Ya-Yun Xu (Nanjing University of Chinese Medicine)H-Index: 3
#2Fang Long (Nanjing University of Chinese Medicine)H-Index: 3
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 6 authors...
Abstract In traditional Chinese medicine practice, crude herbs are often subjected to traditional processing (Paozhi in Chinese) for a special medicinal purpose. Bran-frying is one of processing methods for Paeoniae Radix Alba (PRA). Previous studies found that paeoniflorin and paeoniflorin sulfonate, a principle bioactive compound and its sulfur-fumigation induced characteristic sulfur-containing derivative, could be used together with sulfur dioxide residue as chemical markers for the quality ...
3 CitationsSource
#1Cheng-Ying Wu (Nanjing University of Chinese Medicine)H-Index: 2
#2Ming Kong (Nanjing University of Chinese Medicine)H-Index: 11
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 9 authors...
Abstract Ginger (Zingiberis Rhizoma), a commonly-consumed food supplement, is often sulphur-fumigated during post-harvest handling, but it remains unknown if sulphur fumigation induces chemical transformations in ginger. In this study, the effects of sulphur fumigation on ginger chemicals were investigated by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS)-based metabolomics. The results showed that sulphur fumigation signi...
10 CitationsSource
#1Xiu-Yang Li (Nanjing University of Chinese Medicine)H-Index: 6
#2Fang Long (Nanjing University of Chinese Medicine)H-Index: 3
Last. Song-Lin Li (Nanjing University of Chinese Medicine)H-Index: 26
view all 8 authors...
Abstract Sulfur fumigation can induce chemical transformation of bioactive components, consequently the alteration of bioactivities or even toxicities of medicinal herbs. Inspecting Chinese patent medicines (CPM) contained sulfur-fumigated constituent herbs is crucial for ensuring the safety and efficacy of CPM. Paeonifiorin sulfonate is a sulfur-fumigation induced compound of Moutan Cortex (MC), one of the main constituent herbs of a commonly used CPM Liu-Wei-Di-Huang-Wan (LWDHW). Herein, we in...
6 CitationsSource