Ji-Sook Lee
Health Science University
ChemokineImmunoglobulin EMolecular biologyChemistryApoptosisImmunologyAllergyInflammationEosinophilBronchoalveolar lavageHouse dust miteAtopic dermatitisCytokineCancer researchChemotaxisMAPK/ERK pathwayMedicineBiologyCell biologyPharmacology
86Publications
18H-index
812Citations
Publications 86
Newest
#1Geunyeong Kim (Eulji University)H-Index: 4
#2Minhwa Hong (Eulji University)
Last. Ran-Sook Woo (Eulji University)H-Index: 8
view all 13 authors...
It is difficult to treat allergic diseases including asthma completely because its pathogenesis remains unclear. House dust mite (HDM) is a critical allergen and Toll-like receptor (TLR) 4 is a member of the toll-like receptor family, which plays an important role in allergic diseases. The purpose of this study was to characterize a novel allergen, Der f 38 binding to TLR4, and unveil its role as an inducer of allergy. Der f 38 expression was detected in the body and feces of Dermatophagoides fa...
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#1Ji-Sook Lee (Health Science University)H-Index: 18
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#8Eun Ju Yang (Daegu Haany University)H-Index: 2
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#1Ji-Sook LeeH-Index: 18
#2Na Rae LeeH-Index: 5
Last. In Sik KimH-Index: 17
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S100A8 and S100A9 function as essential factors in inflammation, and also exert anti-tumor or tumorigenic activity depending on the type of cancer. Chronic eosinophilic leukemia (CEL) is a rare hematological malignancy having elevated levels of eosinophils, and characterized by the presence of the FIP1L1-PDGFRA fusion gene. In this study, we examined the pro-apoptotic mechanisms of S100A8 and S100A9 in FIP1L1-PDGFRα+ eosinophilic cells and hypereosinophilic patient cells. S100A8 and S100A9 induc...
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#1Da Hye Kim (Eulji University)H-Index: 5
#2Ayoung Gu (Eulji University)H-Index: 5
Last. In Sik Kim (Eulji University)H-Index: 17
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S100A8 and S100A9 are important proteins in the pathogenesis of allergy. Asthma is an allergic lung disease, characterized by bronchial inflammation due to leukocytes, bronchoconstriction, and allergen-specific IgE. In this study, we examined the role of S100A8 and S100A9 in the interaction of cytokine release from bronchial epithelial cells, with constitutive apoptosis of neutrophils. S100A8 and S100A9 induce increased secretion of neutrophil survival cytokines such as MCP-1, IL-6 and IL-8. Thi...
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#1Ji Yeong Ahn (Eulji University)H-Index: 1
#2In Sik Kim (Eulji University)H-Index: 17
Last. Ji-Sook Lee (Health Science University)H-Index: 18
view all 3 authors...
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#1Kyung-Jae Cha (Eulji University)H-Index: 3
#2Chang-Seob SongH-Index: 1
Last. In Sik Kim (Eulji University)H-Index: 17
view all 7 authors...
Chaenomeles sinensis Koehne (CS) has been used in a traditional oriental medicine for treating throat diseases, anaphylaxis, viral infection, and inflammation. This study investigated the underlying mechanism of anti-allergic effect of CS. Leaves of CS plants were dried, powdered, and then underwent extraction with DMSO. Both ELISA and western blotting were performed to evaluate cytokine concentration and the expression and activation of filaggrin and JNK. Five-week-old female NC/Nga mice were u...
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#1Mun Jeong Kim (Eulji University)H-Index: 3
#2Mi Ae Im (Eulji University)H-Index: 2
Last. In Sik Kim (Eulji University)H-Index: 17
view all 7 authors...
: Atopic dermatitis (AD) is an inflammatory skin disorder caused by immunological dysregulation and genetic factors. Whether the expression levels of cytokine and skin barrier protein were altered by S100 calcium binding protein A8 (S100A8) and S100A9 in human keratinocytic HaCaT cells was examined in the present study. Alterations of cytokine expression were examined by ELISA following treatment with S100A8/9 and various signal protein‑specific inhibitors. Activation of the mitogen activated pr...
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#1Kyung-Jae Cha (Eulji University)H-Index: 3
#2Ayesha Kashif (Eulji University)H-Index: 6
Last. In Sik Kim (Eulji University)H-Index: 17
view all 6 authors...
: This study investigated the anti-allergic effect of Poncirus trifoliata (L.) Raf. (PT) on human keratinocytic HaCaT cells in vitro and on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis-like lesions in vivo. The release of TARC, MCP-1, IL-6 and IL-8 is increased by IFN-γ and TNF-α in HaCaT cells, and PT extract suppressed the increased production of TARC, MCP-1, IL-6, and IL-8. PT extract recovered the expression of filaggrin decreased by IFN-γ and TNF-α. in vivo experiment, PT admin...
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#1Min A Kim (Eulji University)
#2In Sik Kim (Eulji University)H-Index: 17
Last. Ji-Sook Lee (Health Science University)H-Index: 18
view all 3 authors...
대사증후군과 알레르기 비염은 중요한 만성질환이다. 본 연구에서는 대사증후군의 각 항목에 따른 알레르기 비염 유병률의 관계를 분석하였다. 제4, 5, 6기 및 제7기 1차년도 국민건강 영양조사 자료를 이용한 것으로(KNHANES Ⅳ, Ⅴ, Ⅵ, Ⅶ-1)(2007∼2016년) 이 자료를 통합하여. 51,854명의 연구대상자를 선정하였다. 연령대는 청장년(19∼39세), 중년(40∼64세), 노년(65세 이상)으로 분류하였다. 또 대사증후군에 영향을 미치는 일반적인 특성인 근력운동, 걷기운동, 흡연, 음주가 미치는 영향이 있다는 사실에 근거하여 조사하였다. 따라서 본 연구는 연령대 및 근력운동, 걷기운동, 흡연, 음주에 따라서 대사증후군 및 알레르기 비염의 유병률에 미치는 영향을 조사했다. 연구 결과 전 연령대에서 대사증후군이 없는 대상자가 대사증후군이 있는 대상자보다 알레르기 유병률이 높았고, 이는 연령대가 낮을 수록 알레르기 유병률이 높은 것으로 나타났다. 종합해 보면, 이 연구의 결...
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