Jae Woong Hwang
Korea University
SOCS3Internal medicineChemokineEndocrinologyNeutrophil extracellular trapsInnate immune systemPeripheral blood mononuclear cellSuppressor of cytokine signaling 1Steroid 11-beta-hydroxylaseProinflammatory cytokine11ß-hydroxysteroid dehydrogenase type 1EndogenyTumor necrosis factor alphaChemistryAdipokineImmunologyImmunohistochemistryStimulationVirusInterferonSubmucosal glandsWestern blotToll-like receptorAdiponectinInflammationInterferon-stimulated geneImmunotherapyInfiltration (medical)TLR3CytokineAdiponectin receptor 1TLR7DexamethasoneCortisoneSodium hydrosulfideGlucocorticoidInterferon gammaPathogenesisNasal polypsChemokine secretionCell junctionIn patientLeukocyte migrationSecretionCancer researchEpitheliumMucous membrane of noseMedicineCholesterol side-chain cleavage enzyme
7Publications
4H-index
44Citations
Publications 7
Newest
#1Jae Woong Hwang (KU: Korea University)H-Index: 4
#2Young Chan Kim (KU: Korea University)H-Index: 2
Last. Sang Hag Lee (KU: Korea University)H-Index: 23
view all 6 authors...
BACKGROUND Little is known about the role of lymphotoxins (LTs) family in the sinonasal mucosa of patients with chronic rhinosinusitis (CRS). This study aims at investigating the expression of LIGHT, LTα, LTβ, and their receptors, LTβR and HVEM in normal and inflammatory sinus mucosa, and the effect of LIGHT and LTalpha1beta2 on chemokine secretion in epithelial cells, epithelial permeability, and leukocyte migration. MATERIAL AND METHODS The expression of LTs family in sinonasal mucosa was eval...
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#1Jae Woong Hwang (KU: Korea University)H-Index: 4
#2Kijeong Lee (KU: Korea University)H-Index: 7
Last. Sang Hag Lee (KU: Korea University)H-Index: 23
view all 6 authors...
Abstract Background Little is known about the antiviral responses in the sinonasal mucosa of patients with chronic rhinosinusitis (CRS). Objective we investigated the presence of virus, the expression of TLR3 and TLR7, and interferon (IFN) and IFN-stimulated genes (ISGs) in healthy mucosa of control and inflammatory sinus mucosa of CRS patients, and evaluated whether the levels of IFN and ISGs may be affected by CRS-related cytokines and by the treatment with macrolides, dexamethasone, or TLR3 a...
8 CitationsSource
#1Jae Woong Hwang (KU: Korea University)H-Index: 4
#2Jae Hyung Kim (KU: Korea University)H-Index: 2
Last. Sang Hag Lee (KU: Korea University)H-Index: 23
view all 8 authors...
BACKGROUND: Neutrophil extracellular traps (NETs) participate in innate immunity by trapping microorganisms. Their pathophysiological implications have not been defined in chronic rhinosinusitis (CRS). OBJECTIVE: We investigated the presence of NETs in nasal secretion of patients with stable or exacerbated CRS and evaluated whether NETs participate in the secretion of chemokines in sinonasal epithelial cells, the epithelial permeability, and transendothelial leucocyte migration, and elucidate wh...
4 CitationsSource
#1Young Joon Jun (KU: Korea University)H-Index: 9
#2Se Jin Park (KU: Korea University)H-Index: 11
Last. Sunki Lee (KU: Korea University)H-Index: 15
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SummaryBackground Glucocorticoids are used to treat allergic rhinitis, but the mechanisms by which they induce disease remission are unclear. 11β-hydroxysteroid dehydrogenase (11β-HSD) is a tissue-specific regulator of glucocorticoid responses, inducing the interconversion of inactive and active glucocorticoids. Objective We analysed the expression and distribution patterns of 11β-HSD1, 11β-HSD2, and steroidogenic enzymes in normal and allergic nasal mucosa, and cytokine-driven regulation of the...
11 CitationsSource
#1Jae Woong Hwang (KU: Korea University)H-Index: 4
#2Young Joon Jun (KU: Korea University)H-Index: 9
Last. Sang Hag Lee (KU: Korea University)H-Index: 23
view all 9 authors...
Bcground: Chronic rhinosinusitis with nasal polyps (CRSwNPs) or CRS without nasal polyps (CRSsNPs) is characterized by persistent inflammation of sinonasal mucosa. No one causative factor fully explains for the pathological manifestations of CRS. Endogenous hydrogen sulfide (H2S) has been shown to participate in inflammatory diseases, functioning as an inflammatory mediator in various organs. We analyzed the contents and synthesis activity of H2S, the expression and distribution pattern of H2S-g...
5 CitationsSource
#1Tae Hoon Kim (KU: Korea University)H-Index: 38
#1Tae-Hoon Kim (KU: Korea University)H-Index: 18
Last. Sang Hag Lee (KU: Korea University)H-Index: 23
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Background: The aim of this study was to evaluate the role of suppressor of cytokine signaling (SOCS) molecules, SOCS1 and SOCS3, which act as negative regulators of cytokine signaling in various allergic diseases, in patients with mild and moderate/severe persistent allergic rhinitis. Methods: The expression and distribution pattern of SOCS1 and SOCS3 were analyzed in nasal mucosa and peripheral blood mononuclear cells (PBMC) of healthy controls, and patients with mild and moderate/severe persi...
11 CitationsSource
#1Ha Kyun Kim (KU: Korea University)H-Index: 5
#2Tae Hoon Kim (KU: Korea University)H-Index: 38
Last. Sang Hag Lee (KU: Korea University)H-Index: 23
view all 11 authors...
BackgroundAdiponectin, one of the adipokines, has been implicated in the inflammatory process in patients with allergic rhinitis. The level of adiponectin is affected by immunotherapy. Considering ...
3 CitationsSource