Ioanna A. Rota
University of Oxford
Protein sequencingGeneProteomeMutation (genetic algorithm)Compound heterozygosityActinInternal medicinePhenotypeFunction (biology)MutantOncologyHelixAntigenCadherinDominance (genetics)Heterozygote advantageRegulation of gene expressionMüllerian mimicryLymphatic systemChemistryHematologyGene productProgenitor cellImmunologyClinical endpointWild typeRegulatory sequencePlaceboT cellNewborn screeningSequence (medicine)OviductImmunodeficiencyPaliferminOvaryKeratinocyte growth factorCanonical sequenceThymocyteAlemtuzumabUterusSevere combined immunodeficiencyFOXN1Omenn syndromeMultiple sclerosisExpanded Disability Status ScaleCoelomic epitheliumDuct (anatomy)ProteostasisCongenital AlopeciaMullerian DuctsProtein–DNA interactionHuman geneticsCell polarityMutationCancer researchDNA sequencingGeneticsConsensus sequenceDNAMedicineGenetic counselingMesonephric ductChaperoninTranscription factorBiologyImmune systemCell biology
11Publications
3H-index
33Citations
Publications 11
Newest
#1Bergithe E Oftedal (University of Oxford)
#2Stefano Maio (University of Oxford)H-Index: 6
Last. Georg A. Holländer (University of Oxford)H-Index: 53
view all 15 authors...
T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T cell activation induced changes in the proteome are compromised including the formation of nuclear actin filaments and the formation of a normal cell stress response. Consequently, thymocyte maturation and selection, and T cell homeostatic maintenance and receptor-mediated acti...
Source
#1Ioanna A. Rota (University of Oxford)H-Index: 3
#2Adam E. HandelH-Index: 28
Last. Georg A. HolländerH-Index: 53
view all 31 authors...
The transcription factor FOXN1 is a master regulator of thymic epithelial cell development and function. Here we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multi-molecular nuclear condensates essential for the factors transcriptional activity. FOXN1s C-terminal sequence regulates the diffusion velocity within these aggregates and modulates the binding to proximal gene regulatory regions. These dynamics are significantly altered in a pat...
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#1Laura Santana Gonzalez (University of Oxford)H-Index: 3
#2Ioanna A. Rota (University of Oxford)H-Index: 3
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 10 authors...
The conduits of life; the animal oviducts and human fallopian tubes are of paramount importance for reproduction in amniotes. They connect the ovary with the uterus and are essential for fertility as they provide the appropriate environment for gamete maintenance, fertilisation and preimplantation embryonic development. However, some of the most serious pathologies, such as ectopic pregnancy, malignancy and severe infections, occur in the oviducts. They can have drastic effects on fertility, and...
1 CitationsSource
#1Giuliana Giardino (University of Naples Federico II)H-Index: 17
Last. Claudio Pignata (University of Naples Federico II)H-Index: 44
view all 29 authors...
Human nude SCID is a rare autosomal recessive inborn error of immunity (IEI) characterized by congenital athymia, alopecia, and nail dystrophy. Few cases have been reported to date. However, the recent introduction of newborn screening for IEIs and high-throughput sequencing has led to the identification of novel and atypical cases. Moreover, immunological alterations have been recently described in patients carrying heterozygous mutations. The aim of this paper is to describe the extended pheno...
3 CitationsSource
#1Bergithe E Oftedal (University of Oxford)
#2Stefano Maio (University of Oxford)H-Index: 6
Last. Georg A. Holländer (University of Oxford)H-Index: 53
view all 15 authors...
T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T cell activation induced changes in the proteome are compromised including the formation of nuclear actin filaments and the formation of a normal cell stress response. Consequently, thymocyte maturation and selection, and T cell homeostatic maintenance and receptor-mediated acti...
Source
#1J.A. Newman (SGC: Structural Genomics Consortium)H-Index: 18
#1Joseph A. Newman (SGC: Structural Genomics Consortium)H-Index: 17
Last. Opher Gileadi (SGC: Structural Genomics Consortium)H-Index: 42
view all 7 authors...
Forkhead box N1 (FOXN1) is a member of the forkhead box family of transcription factors and plays an important role in thymic epithelial cell differentiation and development. FOXN1 mutations in humans and mice give rise to the "nude" phenotype, which is marked by athymia. FOXN1 belongs to a subset of the FOX family that recognizes an alternative forkhead-like (FHL) consensus sequence (GACGC) that is different from the more widely recognized forkhead (FKH) sequence RYAAAYA (where R is purine, and...
4 CitationsSource
#1Alasdair Coles (University of Cambridge)H-Index: 48
#1Alasdair J Coles (University of Cambridge)H-Index: 8
Last. Joanne L. JonesH-Index: 28
view all 26 authors...
BACKGROUND: The lymphocyte-depleting antibody alemtuzumab is a highly effective treatment of relapsing-remitting multiple sclerosis (RRMS); however 50% of patients develop novel autoimmunity post-treatment. Most at risk are individuals who reconstitute their T-cell pool by proliferating residual cells, rather than producing new T-cells in the thymus; raising the possibility that autoimmunity might be prevented by increasing thymopoiesis. Keratinocyte growth factor (palifermin) promotes thymopoie...
5 CitationsSource
#1J.A. Newman (University of Oxford)H-Index: 18
#2Hazel Aitkenhead (University of Oxford)H-Index: 1
Last. Opher Gileadi (University of Oxford)H-Index: 42
view all 7 authors...
FOXN1 is a member of the forkhead box (FOX) family of transcription factors, and plays an important role in thymic epithelial cell differentiation and function. FOXN1 mutations in humans and mice give rise to the "nude" phenotype which is marked by athymia. FOXN1 belongs to a subset of the FOX family that recognize an alternate consensus sequence (GACGC), which is different from the more widely-recognized canonical sequence consensus RYAAAYA. Here, we present the structure of FOXN1 in complex wi...
3 CitationsSource
#1Angela R. Smith (UMN: University of Minnesota)H-Index: 24
#2Ioanna A. Rota (University of Oxford)H-Index: 3
Last. Bruce R. Blazar (UMN: University of Minnesota)H-Index: 149
view all 8 authors...
Key Points CDH17 is expressed in human thymic epithelial cells. CDH17 mutations may be a rare cause of leaky severe combined immune deficiency that can be corrected by HSCT.
2 CitationsSource