Fangqin Wang
Ocean University of China
GeneBiophysicsMolecular biologyNanoparticleRelative humidityComposite materialAerolysinShrinkageNanocarriersChemistryLower critical solution temperatureMaterials scienceOral administrationHyaluronic acidCurcuminPalm stearinAeromonas hydrophilaChitosanDrug deliveryHemolysisDeoxycholic acidIntestinal permeabilityFucoxanthinMicrobial antigenSargassum thunbergiiVaccine deliveryLipid coreThermo responsiveGastric fluidIntestinal fluidAnti cancer drugsChromatographyCancer researchColorectal cancerDNAZeta potentialProtein adsorptionMicrobiology
5Publications
3H-index
49Citations
Publications 5
Newest
#1Ting Wang (Ocean University of China)H-Index: 5
#2Fangqin Wang (Ocean University of China)H-Index: 3
Last. Ya Liu (Ocean University of China)H-Index: 21
view all 7 authors...
Abstract Colorectal cancer (CRC) is a prevalent and fatal cancer. Oral administration provided the potential for in situ treatment of the colorectal cancer. However, drugs couldn't be well-absorbed mainly due to its degradation in the gastric area and poor intestinal permeability. In this study, we synthesized deoxycholic acid and hydroxybutyl decorated chitosan nanoparticles (DAHBC NPs) as oral curcumin (CUR) delivery system for colorectal cancer treatment. DAHBC with lower critical solution te...
4 CitationsSource
#1Xuanxuan Wang (Ocean University of China)H-Index: 2
#2Hongyan LiH-Index: 1
Last. Ying WangH-Index: 4
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The objective of this study was to isolate fucoxanthin from Sargassum thunbergii and develop microcapsules with palm stearin as the solid lipid core for stability and efficient oral delivery of fucoxanthin. The microcapsules had smooth surfaces with the volume weighted mean diameter (d4.3) of 19.19 μm. Encapsulation efficiency and loading capacity of microcapsules with fucoxanthin were 98.3% and 0.04%, respectively. Moreover, the fucoxanthin in microcapsules presented higher stability than free ...
12 CitationsSource
#1Fangqin Wang (Ocean University of China)H-Index: 3
#2Guixue Xia (Ocean University of China)H-Index: 8
Last. Xiguang Chen (Ocean University of China)H-Index: 61
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Abstract A series of deoxycholate-chitosan-hydroxybutyl (DAHBCs) with different degrees of substitution (DS) of hydrophobic deoxycholate (DOCA) were successfully synthesized. The lower critical solution temperature (LCST) of various DAHBCs could be adjusted from 35.4 °C to 42.1 °C by controlling the graft density of DOCA. DAHBCs could self-assemble into nanoparticles (NPs) which gradually evolved from irregular aggregates to spherical particles with the decrease of the DS of DOCA groups. The siz...
19 CitationsSource
#1Ya Liu (Ocean University of China)H-Index: 21
#2Fangqin Wang (Ocean University of China)H-Index: 3
Last. Xiguang Chen (Ocean University of China)H-Index: 61
view all 7 authors...
Abstract Here we described nano-polyplexes (NPs) made of oleoyl-carboxymethy-chitosan (OCMCS)/hyaluronic acid (HA) as novel potential carriers for oral gene vaccines delivery. Aerolysin gene (aerA) of Aeromonas hydrophila as microbial antigen was efficiently loaded to form OCMCS-HA/aerA (OHA) NPs. OHA NPs performed the optimal parameters, i.e. smallest (154.5 ± 9.4 nm), positive charged (+7.9 ± 0.5 mV) and monodispersed system with the N/P ratio of 5 and OCMCS/HA weight ratio of 4. Upon the intr...
20 CitationsSource
#1Fangqin WangH-Index: 3
#2Guixue XiaH-Index: 8
Last. Xiguang ChenH-Index: 61
view all 11 authors...
A series of deoxycholate-chitosan-hydroxybutyl (DAHBCs) with different degrees of substitution (DS) of hydrophobic deoxycholate (DOCA) were successfully synthesized. The lower critical solution temperature (LCST) of various DAHBCs could be adjusted from 35.4°C to 42.1°C by controlling the graft density of DOCA. DAHBCs could self-assemble into nanoparticles (NPs) which gradually evolved from irregular aggregates to spherical particles with the decrease of the DS of DOCA groups. The size of DAHBCs...