Mee-Ra Rhyu
Rice University
EndocrinologyReceptorChemistryMonascusUmamiGinsengVascular smooth muscleLigusticumCapillary electrophoresisFood scienceNitric oxideBiochemistryTraditional medicineMedicineOvariectomized ratEstrogen receptorBiologyTasteEstrogen receptor betaPharmacology
55Publications
12H-index
444Citations
Publications 44
Newest
#1Mee-Ra RhyuH-Index: 12
#2Yiseul KimH-Index: 9
Last. Vijay LyallH-Index: 23
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In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption. Many plant-derived molecules demonstrate their chemesthetic properties via the opening of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) channels. TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expresse...
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Interaction between umami and bitter taste has long been observed in human sensory studies and in neural responses in animal models, however, the molecular mechanism for their action has not been delineated. Humans detect diverse bitter compounds using 25-30 members of the type 2 taste receptor (TAS2R) family of G protein-coupled receptor. In this study, we investigated the putative mechanism of antagonism by umami substances using HEK293T cells expressing hTAS2R16 and two known probenecid-insen...
1 CitationsSource
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#1Choa Park (Sejong University)H-Index: 7
#2Joonwoo Park (Sejong University)H-Index: 9
Last. Young Joo Lee (Sejong University)H-Index: 24
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: Atherosclerosis is the most common root cause of arterial disease, such as coronary artery disease and carotid artery disease. Hypoxia is associated with the formation of macrophages and increased inflammation and is known to be present in lesions of atherosclerotic. Vascular smooth muscle cells (VSMCs) are one of the major components of blood vessels, and hypoxic conditions affect VSMC inflammation, proliferation and migration, which contribute to vascular stenosis and play a major role in th...
3 CitationsSource
#1Heewon Song (Sejong University)H-Index: 7
#2Joonwoo Park (Sejong University)H-Index: 9
Last. Young Joo Lee (Sejong University)H-Index: 24
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Abstract Background Ginsenoside Rf is a ginseng saponin found only in Panax ginseng that affects lipid metabolism. It also has neuroprotective and antiinflammatory properties. We previously showed that Korean Red Ginseng (KRG) inhibited the expression of cyclooxygenase-2 (COX-2) by hypoxia via peroxisome proliferator–activated receptor gamma (PPARγ). The aim of the current study was to evaluate the possibility of ginsenoside Rf as an active ingredient of KRG in the inhibition of hypoxia-induced ...
7 CitationsSource
#1Yi-Seul KimH-Index: 13
#1Yiseul KimH-Index: 9
Last. Mee-Ra RhyuH-Index: 12
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Abstract Food protein hydrolysates created by natural fermentation have been used for centuries as food flavorings. The aim of this study was to define the key umami -active fraction of modernized Korean soy sauce (mJGN) and the impact thereof on bitter-masking of human sensory and bitter-taste receptor-expressing cells. We found strong correlations between taste profiles of mJGN and a contained fraction (F05). The latter contained compounds of less than 500 Da, and elicits a distinct umami tast...
11 CitationsSource
#1Joonwoo Park (Sejong University)H-Index: 9
#2Phuong T.C. Bui (Sejong University)H-Index: 2
Last. Young Joo Lee (Sejong University)H-Index: 24
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The first record of ginseng use dates back over two millennia, and ginseng is now popular in more than 35 countries. Ginsenosides are the pharmacological constituents responsible for the beneficial effects of ginseng. There is increasing evidence that ginseng and its bioactive ingredients are involved in the regulation of nuclear receptors, molecules that act in response to the specific binding of hormones, which link to a diverse array of signaling pathways, such as the ERK and PI3K/Akt pathway...
12 CitationsSource
#1Yi-Seul KimH-Index: 13
#1Yiseul KimH-Index: 9
Last. Mee-Ra RhyuH-Index: 12
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Ligularia fischeri (Ledeb.) Turcz., a perennial plant native to northeastern Asia, has long been used as folk remedies for the alleviation of inflammatory symptoms. We investigated whether the extract of L. fischeri (LFEx) and caffeoylquinic acid (CQA) derivatives, the pharmacologically active ingredients identified from L. fischeri, regulate inflammation via a transient receptor potential vanilloid 1 (TRPV1)-mediated pathway. Changes in intracellular Ca2+ levels to the LFEx and trans-5-O-CQA, 3...
8 CitationsSource
#1Eun-Young KimH-Index: 21
#1Eun Young KimH-Index: 42
Last. Mee-Ra RhyuH-Index: 12
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We investigated the effects of long-term administration of black cohosh extract (BcEx) on serum lipid profiles and vasomotor responses in ovariectomized (OVX) rats and compared them with those of rats administered 17β-estradiol (E2) or raloxifene, a selective estrogen receptor modulator. Vehicle (OVX- or sham-control), BcEx (0.5 or 3.0 mg/kg/day), E2 (0.5 mg/kg/day), or raloxifene (2.5 mg/kg/day) were injected subcutaneously for 5 weeks, and serum lipid profiles and vasomotor responses were meas...
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#1Joonwoo Park (Sejong University)H-Index: 9
#2Myeong Kuk Shim (Sejong University)H-Index: 3
Last. Young Joo Lee (Sejong University)H-Index: 24
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Abstract Background We have previously found that methyl syringate is a specific and selective agonist of the human transient receptor potential channel ankyrin 1 (TRPA1) and suppresses food intake and gastric emptying in imprinting control region mice. Because TRPA1 has been implicated in inflammatory responses, and inflammation and tumorigenesis are stimulated by the cyclooxygenase-2 (COX-2)/prostaglandin E2 pathway in hypoxic cancer cells. Purpose This study examined the effects of methyl syr...
14 CitationsSource