Pan Xie
Central South University
GeneSurvival analysisCell cycle checkpointPharmacodynamicsPharmacokineticsDrug resistanceGene silencingCancerInternal medicinePhenotypeGenomeOncologyGene expressionPharmacogenomicsApoptosisMolecular geneticsIn vivoNeuroblastoma RAS viral oncogene homologCmaxWestern blotChemotherapyPolydactylyMelanomaCytarabineGliomaCminMyeloid leukemiaMetastasisDiseaseOlmesartanDrugIrbesartanAngiogenesisFluorouracilRepaglinideCytogenetically normal acute myeloid leukemiaClose relationshipAffect (psychology)Methylenetetrahydrofolate reductaseIncidence (epidemiology)MutationCancer researchProportional hazards modelColorectal cancerClinical trialGeneticsRNA splicingPharmacogeneticsCompeting endogenous RNABioinformaticsCell growthSignal transductionClinical pharmacologyRNAComputational biologyMedicineArea under the curveBiologyMitosisPharmacology
8Publications
4H-index
50Citations
Publications 8
Newest
#1Pan Xie (CSU: Central South University)H-Index: 4
#2Fu-Qiang Yuan (CSU: Central South University)H-Index: 1
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
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Background: DCBLD2 is highly expressed in various cancers, including colorectal cancer. DCBLD2 overexpression promotes tumor occurrence, development, and metastasis. However, DCBLD2 sensitivity to chemotherapy drugs and its mechanism on tumor development are unknown. Methods: DCBLD2 expression differences in cancer and normal tissues were obtained from GEO and TCGA databases. DCBLD2 influence on prognosis was also compared, and the database analysis results were verified via the analysis of clin...
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#1Pan XieH-Index: 4
#2Fu-Qiang YuanH-Index: 1
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#1Pan Xie (CSU: Central South University)H-Index: 4
#2Jun-Luan MoH-Index: 2
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
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BACKGROUND Colorectal cancer (CRC) is a disease with high morbidity and mortality rates. 5-fluorouracil (5-FU) is the first-line recommended drug for chemotherapy in patients with CRC, and it has a good effect on a variety of other solid tumors as well. Unfortunately, however, due to the emergence of drug resistance the effectiveness of treatment may be greatly reduced. In the past decade, major progress has been made in the field of 5-FU drug resistance in terms of molecular mechanisms, pre-cli...
3 CitationsSource
#1Qi Pei (CSU: Central South University)H-Index: 12
#2Jun-Yan Liu (CSU: Central South University)H-Index: 4
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
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Purpose On account of the potential inhibition of OATP1B1 (organic anion transporting polypeptide) by angiotensin II receptor blockers (ARBs) and the effects of SLCO1B1 (solute carrier organic anion transporter family member) polymorphism, the aim of current study is to assess the impact of ARBs on the pharmacokinetics (PK) and pharmacodynamics (PD) of repaglinide in Chinese healthy volunteers with different SLCO1B1 genotypes.
3 CitationsSource
#1Tao Zhu (CSU: Central South University)H-Index: 13
#2Pan Xie (CSU: Central South University)H-Index: 4
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
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AIMS: Despite therapeutic advances in glioma management including surgery, radiation, and chemotherapy, the improvement of patient outcome is far from satisfactory. Nucleolar and spindle-associated protein 1 (NUSAP1) is an important functional protein during mitosis, and its abnormal expression is implicated in progression of different types of tumors. However, the role of NUSAP1 in gliomas remains unclear. METHODS: NUSAP1 expression in gliomas with different grades was investigated based on GEO...
16 CitationsSource
#1Ma-Sha Huang (CSU: Central South University)H-Index: 6
#2Tao Zhu (CSU: Central South University)H-Index: 13
Last. Zhao-Qian Liu (CSU: Central South University)H-Index: 49
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Abstract Accumulating evidence has shown that lncRNAs and circRNAs are novel regulators of gene expression. The discovery of numerous lncRNAs and circRNAs, and investigation into their structures and functions will contribute to our understanding of the pathogenesis of diseases as well as better prevention, diagnosis, and treatment of diseases. There is a close relationship between circRNAs and lncRNAs regarding their origins and functions. Recent studies have shown that non-coding linear and ci...
16 CitationsSource
To find the relationship between long non-coding RNA (lncRNA) based on data mining methods. Methods: We use a whole genome mRNA expression data set (GSE15605) from the gene expression ominibus database to find the lncRNAs which relate to melanoma. Results: Four lncRNAs (LINC01213, PGM5-AS1, LINC01133 and LOC284578) were significantly associated with the incidence and development of melanoma. Meanwhile, LINC01213, LINC01133 and LOC284578 were correlated with BRAF mutation, and PGM5-AS1 was relate...
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#1Han Yan (CSU: Central South University)H-Index: 12
#2Lu WenH-Index: 1
Last. Xiao-Ping ChenH-Index: 28
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// Han Yan 1, 2, 4 , Lu Wen 3 , Dan Tan 1, 2, 4 , Pan Xie 1, 2, 4 , Feng-mei Pang 1, 2, 4 , Hong-hao Zhou 1, 2, 4 , Wei Zhang 1, 2, 4 , Zhao-qian Liu 1, 2, 4 , Jie Tang 1, 2, 4 , Xi Li 1, 2, 4 , Xiao-ping Chen 1, 2, 4 1 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China 2 Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China 3 Department of Diagnostic Radiolog...
8 CitationsSource