Véronique Vendrely
University of Bordeaux
CancerInternal medicineRadiologySurgeryOncologyNanoparticleProspective cohort studyChemotherapyNeoadjuvant therapyChemoradiotherapyConcomitantFluorouracilOxaliplatinAdenocarcinomaHafnium oxideLocally advancedCancer researchRadiation therapyColorectal cancerMedicineGastroenterology
Publications 208
#1Nicolas Meillan (University of Paris)H-Index: 1
#2A. OrthuonH-Index: 4
Last. William KaoH-Index: 1
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Abstract null null Purpose null The aim of this study is to correlate locoregional relapse with radiation therapy volumes in patients with rectal cancer treated with neoadjuvant chemoradiation in the ACCORD 12/0405-PRODIGE 02 trial. null null null Patients and methods null We identified patients who had a locoregional relapse included in ACCORD 12 database. We studied their clinical, radiological, and dosimetric data to analyze the dose received by the area of relapse. null null null Results nul...
#1Véronique Vendrely (University of Bordeaux)H-Index: 11
#2S. Benoist (Université Paris-Saclay)
Resume null null Le traitement des cancers du rectum repose sur une strategie multidisciplinaire, associant radiotherapie, chimiotherapie et chirurgie dont les modalites et la sequence ont change en 2020. La radiotherapie suivie d’une chirurgie a permis de reduire les recidives locales a des taux inferieurs a 5 % dans les centres experts, sans benefice sur la survie et au prix d’une certaine morbidite et de sequelles fonctionnelles. L’introduction de la chimiotherapie en situation neoadjuvante a...
#2Etienne BuscailH-Index: 11
Last. Christophe LaurentH-Index: 68
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BACKGROUND Neoadjuvant treatment (NAT) is debated for borderline resectable pancreatic cancer (BRPC). This retrospective study assessed the impact of NAT on R0 rate and survival for BRPC patients in comparison with upfront surgery (US). MATERIAL AND METHODS Between 2010 and 2017 patient records for all consecutive patients treated for BRPC according to NCCN 2017 were reviewed. The endpoints analysed were R0 rate, recurrence-free-survival (RFS) and overall survival (OS). RESULTS Seventy-nine pati...
#1Imène Marref (French Institute of Health and Medical Research)H-Index: 1
#2Gaëlle Romain (French Institute of Health and Medical Research)H-Index: 3
Last. Côme LepageH-Index: 37
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Abstract null null Background null Little is known about the management of squamous cell carcinoma of the anal canal and its recurrence at a population level. The aim of this study was to draw a picture of management, recurrence and survival in squamous cell carcinoma of the anal canal. null null null Material and methods null The 5-year probability of recurrences was estimated using the cumulative incidence function to consider competing risks of death. Net survival was estimated and a multivar...
#2Maylis CapdepontH-Index: 15
Last. Anne RullierH-Index: 28
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The pathological nodal stage, determination of which requires examination of ≥ 12 lymph nodes, is one of the main prognostic factors in rectal cancer. Neoadjuvant chemoradiotherapy (CRT) may reduce the number of both lymph nodes retrieved and positive lymph nodes. Induction chemotherapy before CRT aimed at reducing the rate of distant metastases. However, the impact of this new treatment on number of lymph nodes retrieved and positive lymph nodes is unknown. This study was performed to evaluate ...
#1Thierry Conroy (University of Lorraine)H-Index: 60
Last. Isabelle MarquisH-Index: 1
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Summary Background Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery, and adjuvant chemotherapy controls local disease, but distant metastases remain common. We aimed to assess whether administering neoadjuvant chemotherapy before preoperative chemoradiotherapy could reduce the risk of distant recurrences. Methods We did a phase 3, open-label, multicentre, randomised trial at 35 hospitals in France. Eligible patients were adults aged 18–75 years and had newly diagnosed,...
14 CitationsSource
#2Laurent QueroH-Index: 14
Last. Véronique Vendrely (University of Bordeaux)H-Index: 11
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Abstract Introduction for localized T1N0 squamous cell carcinoma of the anus (SCCA) standard radiotherapy (RT) may result in overtreatment and alternative strategies are debated. Methods T1N0M0 SCCA treated between 2015 and 2020 by local excision (LE) or RT were analyzed from the French prospective FFCD ANABASE cohort. Treatment strategies, recurrence-free and colostomy-free survivals (RFS, CFS) and prognostic factors were reported. Results among 1135 SCCA patients, 99 T1N0M0 were treated by LE(...
#1Quentin DenostH-Index: 20
#2Eric Frison (French Institute of Health and Medical Research)H-Index: 11
Last. Véronique VendrelyH-Index: 23
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AIM Treatment strategies in locally recurrent rectal cancer (LRRC) are complex and need to be balanced against previous treatments received for the primary rectal cancer. Radiotherapy is an important component of treatment in LRRC. However, there is little high quality evidence on the role of re-irradiation in this cohort. METHODS GRECCAR 15 is a prospective, multi-centre, open-label, outcome assessor blinded, superiority randomized controlled phase III clinical trial, comparing neoadjuvant chem...