Hirotaka Sakamoto
University of Oxford
EndocrinologyNeuroscienceReceptorOxytocinGastrin-releasing peptideHypothalamusEstrogenAndrogenPurkinje cellNeuronCerebellumSpinal cordLumbar Spinal CordCerebellar Purkinje cellNeuroactive steroidCentral nervous systemMedicineEstrogen receptorBiologyCell biology
105Publications
28H-index
2,865Citations
Publications 98
Newest
#1Takumi Oti (Kanagawa University)H-Index: 6
#2Tatsuya Sakamoto (Okayama University)H-Index: 26
Last. Hirotaka Sakamoto (Okayama University)H-Index: 28
view all 3 authors...
Oxytocin is produced in the hypothalamus and stimulates uterine contraction and milk ejection. While many people consider oxytocin to be a female hormone, it is reported that, in men, the plasma ox...
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The spinal ejaculation generator (SEG) is located in the central gray (lamina X) of the rat lumbar spinal cord and plays a pivotal role in the ejaculatory reflex. We recently reported that SEG neurons express the oxytocin receptor and are activated by oxytocin projections from the paraventricular nucleus of hypothalamus (PVH). However, it is unknown whether the SEG responds to oxytocin in vivo. In this study, we analyzed the characteristics of the brain–spinal cord neural circuit that controls m...
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#1Takumi Oti (Kanagawa University)H-Index: 6
#2Keita Satoh (Okayama University)H-Index: 7
Last. Hirotaka Sakamoto (University of Oxford)H-Index: 28
view all 12 authors...
Summary Oxytocinergic neurons in the paraventricular nucleus of the hypothalamus that project to extrahypothalamic brain areas and the lumbar spinal cord play an important role in the control of erectile function and male sexual behavior in mammals. The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord is an important component of the neural circuits that control penile reflexes in rats, circuits that are commonly referred to as the “spinal ejaculation generator (SEG).” We ha...
3 CitationsSource
#1Yuta Kohro (Kyushu University)H-Index: 11
#2Tsuyoshi Matsuda (Kyushu University)H-Index: 5
Last. Makoto Tsuda (Kyushu University)H-Index: 51
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Astrocytes are critical regulators of CNS function and are proposed to be heterogeneous in the developing brain and spinal cord. Here we identify a population of astrocytes located in the superficial laminae of the spinal dorsal horn (SDH) in adults that is genetically defined by Hes5. In vivo imaging revealed that noxious stimulation by intraplantar capsaicin injection activated Hes5+ SDH astrocytes via α1A-adrenoceptors (α1A-ARs) through descending noradrenergic signaling from the locus coerul...
5 CitationsSource
#1Takashi Miyata (Nagoya University)H-Index: 14
#2Daisuke Hagiwara (Nagoya University)H-Index: 25
Last. Hiroshi Arima (Nagoya University)H-Index: 28
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Summary Misfolded or unfolded proteins in the endoplasmic reticulum (ER) are said to be degraded only after translocation or isolation from the ER. Here, we describe a mechanism by which mutant proteins are degraded within the ER. Aggregates of mutant arginine vasopressin (AVP) precursor were confined to ER-associated compartments (ERACs) connected to the ER in AVP neurons of a mouse model of familial neurohypophysial diabetes insipidus. The ERACs were enclosed by membranes, an ER chaperone and ...
1 CitationsSource
#1Natsuko Kawakami (University of Oxford)H-Index: 1
#2Akito Otubo (Okayama University)
Last. Hirotaka Sakamoto (University of Oxford)H-Index: 28
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#1Miwako Masugi-Tokita (Kyoto University)H-Index: 2
#2Keiji Tomita (Shiga University of Medical Science)H-Index: 4
Last. Akihiro Kawauchi (Shiga University of Medical Science)H-Index: 30
view all 7 authors...
Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of the group III mGluRs, which are negatively coupled to adenylate cyclase via Gi/Go proteins and localized to presynaptic active zones of the mammalian central nervous system (CNS). To elucidate the mechanism of impaired reproductivity of mGluR7 knockout (KO) mice, we investigated sexual behavior in this line, which exhibits ejaculatory disorder, although with normal sexual motivation and erectile function. To identify the site of a...
1 CitationsSource
#1Akito Otubo (Okayama University)
#2Natsuko Kawakami (University of Oxford)H-Index: 1
Last. Hirotaka Sakamoto (University of Oxford)H-Index: 28
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#1Shoko Sagoshi (University of Tsukuba)H-Index: 2
#2Sho Maejima (Saitama University)H-Index: 7
Last. Sonoko Ogawa (University of Tsukuba)H-Index: 50
view all 10 authors...
Abstract Two types of nuclear estrogen receptors, ERα and ERβ, have been shown to be differentially involved in the regulation of various types of behaviors. Due to a lack of tools for identifying ERβ expression, detailed anatomical distribution and neurochemical characteristics of ERβ expressing cells and cellular co-expression with ERα remain unclear. We have generated transgenic mice ERβ-RFPtg, in which RFP was inserted downstream of ERβ BAC promotor. We verified RFP signals as ERβ by confirm...
1 CitationsSource
#1Asuka Hirooka (Okayama University)H-Index: 1
#2Mayuko Hamada (Okayama University)H-Index: 14
Last. Hirotaka Sakamoto (Okayama University)H-Index: 28
view all 8 authors...
Gastrin-releasing peptide (GRP), first isolated from the porcine stomach, is a neuropeptide that modulates the autonomic system in mammals and has previously been considered to be the mammalian equivalent of bombesin, a fourteen amino acid peptide first isolated from the skin of the European fire-bellied toad, Bombina bombina . Bombesin-like peptides and the related neuromedin B (NMB) have since been identified in mammals. However, the orthologous relationships among GRP/NMB/bombesin and their r...
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