Robyn B. Lee
United States Army Medical Research Institute of Chemical Defense
Penetration (firestop)PharmacokineticsInternal medicineEndocrinologyPathologyNot evaluatedAndrologyChemistryToxicokineticsCmaxMethemoglobinCombination drugRoute of administrationChemotherapyPrednisoloneInhalationSalineMetaboliteSodium nitriteCefazolinCyanideNerve agentGuinea pigTriamcinolone acetonideHairlessXylazineRespiratory tractMeloxicamDrugSomanSarinNebulizerSulfur mustardKetamineAnalgesicToxicityAge groupsRate curveSprague dawleyPeak plasmaPlasma concentrationAnesthesiaOxygen saturation (medicine)BiochemistryMedicinePharmacology
5Publications
4H-index
39Citations
Publications 5
Newest
#1Kristina A Pugh (United States Army Medical Research Institute of Chemical Defense)H-Index: 1
#2Kyle J Reitnauer (United States Army Medical Research Institute of Chemical Defense)H-Index: 2
Last. Samantha R. Litvin (United States Army Medical Research Institute of Chemical Defense)H-Index: 1
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In this study, we compared the plasma concentrations of meloxicam in pediatric rat pups (ages: 7, 14, 21, and 28 d) with those of young adult rats. Adult rats received 1.34 mg/kg SC meloxicam to determine the target peak plasma concentration (Cmax) for comparison with the pediatric animals. Pediatric rats received 1.34 mg/kg SC meloxicam, and in all age groups, Cmax met or exceeded that in adults (11.5 ±2.7 μg/mL). Plasma concentrations were similar between male and female pups within age groups...
2 Citations
#2Xinqi Peng (United States Army Medical Research Institute of Chemical Defense)H-Index: 2
Last. Alfred M. Sciuto (United States Army Medical Research Institute of Chemical Defense)H-Index: 20
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Nerve agents pose a threat to the respiratory tract with exposure that could result in acute compromised lung performance and death. The determination of toxicity by inhalation is important for the rational development of timely therapeutic countermeasures. This study was designed to deliver aerosolized dilute nerve agents in a dose-response manner to investigate the extent of lethality of nerve agents: soman, sarin, VX and VR. Male rats (240–270 g) were anesthetized intramuscularly with 10 mg/k...
11 CitationsSource
#1Michael C. Babin (United States Army Medical Research Institute of Chemical Defense)H-Index: 12
#2Karen M. Ricketts (United States Army Medical Research Institute of Chemical Defense)H-Index: 6
Last. John J. BrozettiH-Index: 1
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The eye is considered to be one of the most sensitive organs to sulfur mustard [bis(2‐chloroethyl) sulfide (SM)], with injuries ranging from mild conjunctivitis to advanced corneal disease. Even mild ocular involvement from sulfur mustard exposure can result in both physical and psychological incapacitation. In this study we explored the use of Food and Drug Administration (FDA) approved medications (prednisolone acetate ophthalmic suspension, triamcinolone, and cefazolin) as ocular treatments f...
9 CitationsSource
#1Gary A. Rockwood (United States Army Medical Research Institute of Chemical Defense)H-Index: 16
#2Steven I. Baskin (United States Army Medical Research Institute of Chemical Defense)H-Index: 17
Last. Richard E. SweeneyH-Index: 9
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Abstract Controlled methemoglobin (MHb) formation is one strategy employed to counter cyanide (CN) toxicity. Currently available MHb formers present certain drawbacks and limitations. The purpose of this study was to characterize, in mice, the hematologic effects of the MHb-forming compound p -aminopropiophenone (PAPP), and two structurally-related p -aminophenones, p -aminoheptanoylphenone (PAHP) and p -aminooctanoylphenone (PAOP). Although these three p -aminophenones have been shown previousl...
4 CitationsSource
#1Thomas P. Logan (United States Army Medical Research Institute of Chemical Defense)H-Index: 2
#2Charles B. Millard (United States Army Medical Research Institute of Chemical Defense)H-Index: 4
Last. Rodolfo Bongiovanni (United States Army Medical Research Institute of Chemical Defense)H-Index: 2
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ABSTRACTThe hairless guinea pig (HGP) is used by our laboratory to model the human cutaneous response to sulfur mustard (HD), bis(2-chloroethylsulfide), exposure. We determined the HD content in the skin of HGP after a 7-min exposure to vapors saturated with a mixture of HD and l4C-HD. Concentration/time (CT) values in the range of 2 μg/cm2/min were determined by counting skin 14C disintegrations per min (dpm) in animals euthanized immediately after exposure. These values are similar to human pe...
14 CitationsSource