Courtney Lang
Harvard University
InsulaDefault mode networkMagnetic resonance imagingPsychologyMultivariate statisticsNeuroscienceVoxel-based morphometryOsteoarthritisVentral striatumGrey matterAnterior cingulate cortexAutism spectrum disorderPutamenMajor depressive disorderStriatumNeuropathologyChronic painPrefrontal cortexSupplementary motor areaFunctional connectivityChronic low back painAudiologyAcupunctureNeuroimagingResting state fMRIText miningMedicineCohortPhysical medicine and rehabilitation
28Publications
15H-index
454Citations
Publications 28
Newest
#1Jian Kong (MIT: Massachusetts Institute of Technology)H-Index: 67
#2Zengjian Wang (Harvard University)H-Index: 6
Last. Randy L. Gollub (MIT: Massachusetts Institute of Technology)H-Index: 67
view all 13 authors...
Abstract Objectives Expectation can significantly modulate pain and treatment effects. This study aims to investigate if boosting patients' expectancy can enhance the treatment of knee osteoarthritis (KOA), and its underlying brain mechanism. Methods Seventy-four KOA patients were recruited and randomized to three groups: boosted acupuncture (with a manipulation to enhance expectation), standard acupuncture, or treatment as usual (TAU). Each patient underwent six treatments before being debriefe...
30 CitationsSource
#1Zengjian Wang (Harvard University)H-Index: 9
#2Jiliang FangH-Index: 18
Last. Jian Kong (Harvard University)H-Index: 67
view all 10 authors...
Abstract Transcutaneous vagus nerve stimulation (tVNS) may be a promising treatment for major depressive disorder (MDD). In this exploratory study, fMRI scans were acquired during continuous real or sham tVNS from 41 MDD patients. Then, all patients received real or sham tVNS treatment for four weeks. We investigated the functional connectivity (FC) of the nucleus accumbens (NAc) at different frequency bands during real and sham tVNS and explored their associations with depressive symptom change...
21 CitationsSource
#1Minyoung Jung (University of Fukui)H-Index: 12
#2Yiheng Tu (Harvard University)H-Index: 16
Last. Jian Kong (Harvard University)H-Index: 67
view all 8 authors...
Abstract Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by atypical social communication and repetitive behaviors. In this study, we applied a multimodal approach to investigate brain structural connectivity, resting state activity, and surface area, as well as their associations with the core symptoms of ASD. Data from forty boys with ASD (mean age, 11.5 years; age range, 5.5–19.5) and forty boys with typical development (TD) (mean age, 12.3; age range, ...
22 CitationsSource
#1Fangyuan Cui (Beijing University of Chinese Medicine)H-Index: 3
#2Li Zhou (Beijing University of Chinese Medicine)H-Index: 3
Last. Jian Kong (Harvard University)H-Index: 67
view all 10 authors...
Abnormal corticostriatal resting-state functional connectivity (rsFC) has been implicated in the neuropathology of multiple sclerosis (MS). As a component of the basal ganglia, the striatum is involved in diverse functions including movement, cognition, emotion and limbic information processing. However, the brain circuits of the striatal subregions contributing to the changes in rsFC in RRMS patients remain unknown. As individual striatal subregions are believed to be connected to specific func...
6 CitationsSource
#1Wenwen Song (ZJNU: Zhejiang Chinese Medical University)H-Index: 5
#2Minhui Dai (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
Last. Jian Kong (Harvard University)H-Index: 67
view all 9 authors...
Neuroplasticity is a common phenomenon in the human brain following nerve injury. It is defined as the brain’s ability to reorganize by creating new neural pathways in order to adapt to change. Here, we use task-related and resting-state fMRI to investigate neuroplasticity in the primary sensory (S1) and motor cortex (M1) in patients with acute Bell’s palsy (BP). We found that the period directly following the onset of BP (less than 14 days) is associated with significant decreases in regional h...
4 CitationsSource
#1Wenwen Song (ZJNU: Zhejiang Chinese Medical University)H-Index: 5
#2Zhijian Cao (ZJNU: Zhejiang Chinese Medical University)H-Index: 2
Last. Jian Kong (ZJNU: Zhejiang Chinese Medical University)H-Index: 67
view all 10 authors...
Abstract The striatum plays an important role in controlling motor function in humans, and its degeneration has the ability to cause severe motor disorders. More specifically, previous studies have demonstrated a disruption in the connectivity of the cortico-striatal loop in patients suffering from motor disorders caused by dopamine dysregulation, such as Parkinson's disease. However, little is known about striatal functional connectivity in patients with motor dysfunction not caused by dopamine...
13 CitationsSource
#1Jing Tao (Harvard University)H-Index: 27
#1Jing Tao (Harvard University)H-Index: 7
Last. Jian Kong (Harvard University)H-Index: 67
view all 17 authors...
: The aim of this study is to investigate and compare how 12-weeks of Tai Chi Chuan and Baduanjin exercise can modulate brain structure and memory function in older adults. Magnetic resonance imaging and memory function measurements (Wechsler Memory Scale-Chinese revised, WMS-CR) were applied at both the beginning and end of the study. Results showed that both Tai Chi Chuan and Baduanjin could significantly increase grey matter volume (GMV) in the insula, medial temporal lobe, and putamen after ...
57 CitationsSource
#1Jing Li (Beijing University of Chinese Medicine)H-Index: 6
#1Jing Li (Beijing University of Chinese Medicine)H-Index: 2
Last. Jian Kong (Harvard University)H-Index: 67
view all 15 authors...
Abstract Background Subthreshold depression (StD) is associated with substantial functional impairments due to depressive symptoms that do not fully meet the diagnosis of major depressive disorder (MDD). Its high incidence in the general population and debilitating symptoms has recently put it at the forefront of mood disorder research. Aim In this study we investigated common volumetric brain changes in both young and middle-aged StD patients. Methods Two cohorts of StD patients, young and midd...
14 CitationsSource