Bowen Lei
Sichuan University
Surface modificationSubstrate (chemistry)VicinalMedicinal chemistryCatalysisAlkylationOrganic chemistryNucleophileStereoselectivityChemistryCombinatorial chemistryCycloalkaneAlkeneAmino radicalFunctional groupOxazoleThiazoleIodideTrimethylsilyl azideAlkylAzoleEtherDiamineN-fluorobenzenesulfonimideBioactive moleculesC h bondIron catalyzedBond cleavageReagentCoupling reactionElectrophilePalladiumCobaltOrganic synthesisIodineRegioselectivityCatalytic cycleLigandOxidative addition
6Publications
6H-index
51Citations
Publications 6
Newest
#1Bowen Lei (Sichuan University)H-Index: 6
#2Qi Miao (Sichuan University)H-Index: 3
Last. Ziyuan Li (Sichuan University)H-Index: 11
view all 7 authors...
A novel efficient metal-free aminoiodination of alkenes with N-fluorobenzenesulfonimide (NFSI) through an iodonium intermediate under mild conditions with good regioselectivity and stereoselectivity is reported. Unlike transition-metal catalysed aminative bisfunctionalization with NFSI in which the oxidative addition of NFSI to transition-metals affords an electrophilic amino radical, the oxidation of anionic iodide by NFSI in situ generates an electrophilic iodine cation and an amino nucleophil...
11 CitationsSource
#1Bowen Lei (Sichuan University)H-Index: 6
#2Xiaojiao Wang (Sichuan University)H-Index: 5
Last. Ziyuan Li (Sichuan University)H-Index: 11
view all 5 authors...
An iron-catalysed intermolecular vicinal aminoazidation of alkenes, using N-fluorobenzenesulfonimide (NFSI) and trimethylsilyl azide (TMSN3) as the imidating and azidating reagents respectively, is described, which could potentially provide a valuable route toward diverse vicinal diamine derivatives of great significance in medicinal chemistry and organic synthesis. Such iron-catalysed aminative bisfunctionalization of alkene with NFSI has not yet been reported before. Comparing to previously em...
13 CitationsSource
#1Xiaojiao Wang (Sichuan University)H-Index: 5
#2Bowen Lei (Sichuan University)H-Index: 6
Last. Ziyuan Li (Sichuan University)H-Index: 11
view all 7 authors...
An iron(II)-catalyzed direct imidation of oxazole and thiazole with N-fluorobenzenesulfonimide (NFSI) through C(5)−H bond cleavage is disclosed, providing C5-imidated azoles in moderate to excellent yields with broad substrate scope. This reaction represents the first iron-catalyzed C−H imidation of arene where NFSI serves as the imidation reagent, and potentially constitutes an efficient access to C5-functionalized azole with great medicinal significance.
15 CitationsSource
#1Xiaojiao Wang (Sichuan University)H-Index: 5
#2Bowen Lei (Sichuan University)H-Index: 6
Last. Ziyuan Li (Sichuan University)H-Index: 11
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Direct C5-alkylation of oxazole/thiazole with ether or cycloalkane has been achieved through a cobalt-catalyzed cross-dehydrogenative coupling (CDC) process in moderate to good yields. This transformation represents the first C(sp2)−C(sp3) cross-coupling at the C5-position of the oxazole/thiazole via double C−H bond cleavages. Various functional groups on oxazole/thiazole substrates, as well as water and air, are well-tolerated with this concise and practical protocol, constituting straightforwa...
21 CitationsSource
#1Bowen Lei (Sichuan University)H-Index: 6
#2Xiaojiao Wang (Sichuan University)H-Index: 5
Last. Ziyuan Li (Sichuan University)H-Index: 11
view all 6 authors...
A novel and concise C5-alkylation of oxazoles using alkylboronic acids as alkyl donors via Pd(II)-catalysed C–H bond activation has been achieved in moderate to good yields with satisfactory functional group tolerance. Instead of commonly used BQ as a key promoter, DDQ was discovered to be a better additive that significantly promoted this alkylation. This efficient and advanced method represents the first C(sp2)–C(sp3) cross-coupling reaction at the C5-position of oxazoles, which is particularl...
12 CitationsSource
#1Yao LiH-Index: 1
#2Lifang MaH-Index: 8
Last. Ziyuan LiH-Index: 11
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Homocoupling of oxazole/thiazole via palladium-catalyzed C-H bond activation using oxone as an oxidant has been achieved in moderate to excellent yields with good functional group tolerance. No other additive or ligand was employed in this efficient reaction. Comparing to our previously reported homocoupling of oxazole/thiazole, the absence of stoichiometric silver oxidant renders this reaction more environment-benign and cost-effective. A preliminary mechanism involving a Pd Ⅱ /Pd Ⅳ catalytic c...
5 CitationsSource