Amjad Khan
University of Oxford
PharmacokineticsLigand (biochemistry)Function (biology)CatalysisOxygenaseMolecular recognitionBioavailabilityChemistryEffluxCarnitine biosynthesisProteaseDiseaseGlucuronidaseGlucuronideHydroxylationQuercetinBiochemistryEnzyme catalysisPolyphenolStereochemistryMedicinePharmacology
13Publications
6H-index
41Citations
Publications 14
Newest
#1Soyoung Lee (Charité)H-Index: 17
#2Yong Yu (Johannes Kepler University of Linz)H-Index: 1
Last. Maria Pammer (Johannes Kepler University of Linz)H-Index: 2
view all 48 authors...
Derailed cytokine and immune cell networks account for the organ damage and the clinical severity of COVID-19 (refs. 1-4). Here we show that SARS-CoV-2, like other viruses, evokes cellular senescence as a primary stress response in infected cells. Virus-induced senescence (VIS) is indistinguishable from other forms of cellular senescence and is accompanied by a senescence-associated secretory phenotype (SASP), which comprises pro-inflammatory cytokines, extracellular-matrix-active factors and pr...
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#1Domingo A. Pascual-Figal (Centro Nacional de Investigaciones Cardiovasculares)H-Index: 45
#2Aychel E Roura-Piloto (University of Murcia)H-Index: 1
Last. David Vázquez-Andrés (University of Murcia)H-Index: 1
view all 15 authors...
Background null Colchicine has been proposed as a potential therapy in coronavirus disease 2019 (COVID-19) due to their anti-inflammatory actions. null Methods null The COL-COVID study was a prospective, randomized, controlled and open-label clinical trial that compared colchicine added to standard treatment vs standard treatment in hospitalized COVID-19 patients that do not need mechanical ventilatory support. Colchicine was initiated within the first 48 hours of admission at a 1.5 mg loading d...
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#1Francesco Di PierroH-Index: 12
#2Somia Iqtadar (King Edward Medical University)H-Index: 5
Last. Antonella RivaH-Index: 30
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Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing global pandemic known as COVID-19. Based on the potential antiviral role of quercetin, and on its described anti-blood clotting, anti-inflammatory and antioxidant properties, we hypothesize that subjects with mild COVID-19 treated with Quercetin Phytosome R (QP), a novel bioavailable form of quercetin, may have a shorter time to virus clearance, a milder symptomatology, and higher probabiliti...
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#1Arshad Khan (Hunan University)H-Index: 9
#2Rabia Usman (SEU: Southeast University)H-Index: 9
Last. Mohammed T. Alghamdi (KAU: King Abdulaziz University)H-Index: 4
view all 7 authors...
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#10Bilal Ahmad Khan (DUHS: Dow University of Health Sciences)H-Index: 17
Background Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 candidate. Quercetin has strong antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties, and it is characterized by a very high safety profile, exerted in animals and in humans. Like most other polyphenols, quercetin shows a very low rate of oral absorption and its clinical use is considered by most of mode...
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#1Francesco Di PierroH-Index: 12
#2Amjad Khan (University of Oxford)H-Index: 6
Last. Bikha Ram Devrajani (Liaquat University of Medical and Health Sciences)H-Index: 12
view all 10 authors...
When looking for new antiviral compounds aimed to counteract the COVID-19, a disease caused by the recently identified novel coronavirus (SARS-CoV-2), the knowledge of the main viral proteins is fundamental. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent 26 RNA polymerase, and spike (S) protein. Molecular docking studies have highlighted that quercetin, a natural polyphenol belonging to the flavonol class, inhi...
Source
#1Amjad Khan (University of Oxford)H-Index: 6
#2Christopher J. Schofield (University of Oxford)H-Index: 105
Last. Timothy D. W. Claridge (University of Oxford)H-Index: 60
view all 3 authors...
L-Ascorbate (L-Asc) is often added to assays with isolated Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases to enhance activity. L-Asc is proposed to be important in catalysis by some 2OG oxygenases in vivo. We report observations on the non-enzymatic conversion of 2OG to succinate which is mediated by hydrogen peroxide (H2O2), generated by reaction of L-Asc and dioxygen. Slow non-enzymatic oxidation of 2OG to succinate occurs with some, but not all, other reducing agents commonly used in 2O...
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#1Md. Saiful Islam (University of Oxford)H-Index: 3
#2Michael A. McDonough (University of Oxford)H-Index: 52
Last. Christopher J. Schofield (University of Oxford)H-Index: 105
view all 7 authors...
: JmjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, including splicing regulation, histone modification, transcriptional pause release, hypoxia sensing, and cancer. JMJD6 is reported to catalyze hydroxylation of lysine residue(s) of histones, the tumor-suppressor protein p53, and splicing regulatory proteins, including u2 small nuclear ribonucleoprotein auxiliary factor 65-kDa subunit (U2AF65). JMJD6 is also reported to c...
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#1Christos Pliotas (St And: University of St Andrews)H-Index: 12
#2Samuel C. Grayer (University of Oxford)H-Index: 3
Last. Stuart J. Conway (University of Oxford)H-Index: 29
view all 18 authors...
Ligand binding is one of the most fundamental properties of proteins. Ligand functions fall into three basic types: substrates, regulatory molecules, and cofactors essential to protein stability, reactivity, or enzyme–substrate complex formation. The regulation of potassium ion movement in bacteria is predominantly under the control of regulatory ligands that gate the relevant channels and transporters, which possess subunits or domains that contain Rossmann folds (RFs). Here we demonstrate that...
Source
#1Christos PliotasH-Index: 12
#2Samuel C. GrayerH-Index: 3
Last. Stuart J. ConwayH-Index: 29
view all 18 authors...
Ligand binding is one of the most fundamental properties of proteins. Ligand functions fall into three basic types: substrates, regulatory molecules, and co-factors essential to protein stability, reactivity, or enzyme-substrate complex formation. The regulation of potassium ion movement in bacteria is predominantly under the control of regulatory ligands that gate the relevant channels and transporters, which possess subunits or domains that contain Rossmann folds (RFs). Here we demonstrate tha...
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