Jifeng Zhang
University of Michigan
TransgeneGeneEndothelial stem cellInternal medicineDownregulation and upregulationEndocrinologyPathologyMolecular biologyReceptorChemistryPeroxisome proliferator-activated receptorInflammationCholesterolVascular smooth muscleLipoproteinStem cellCancer researchBiochemistrySignal transductionMedicineTranscription factorBiologyCell biologyPharmacology
150Publications
36H-index
3,330Citations
Publications 146
Newest
#1Yiqin Bai (CAS: Chinese Academy of Sciences)
#2Weili Lin (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
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The European rabbit (Oryctolagus cuniculus) is important as a biomedical model given its unique features in immunity and metabolism. The current reference genome OryCun2.0 established with whole-genome shotgun sequencing was quite fragmented and had not been updated for ten years. In this work, we provided a new rabbit genome assembly UM_NZW_1.0 to improve OryCun2.0 by leveraging the contig lengths based on long-read sequencing and a wealth of available Illumina paired-end sequence data. UM_NZW_...
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#1Ali Z. Siddiqui (UM: University of Michigan)H-Index: 3
#2Umar F. Bhatti (UM: University of Michigan)H-Index: 10
Last. Aaron M. Williams (UM: University of Michigan)H-Index: 13
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Objective: Sepsis causes millions of deaths on a global scale annually. Activation of peptidylarginine deiminase (PAD) enzymes in sepsis causes citrullination of histones, which results in neutroph...
1 CitationsSource
#1Guizhen Zhao (UM: University of Michigan)H-Index: 3
#2Haocheng Lu (UM: University of Michigan)H-Index: 8
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
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AIMS The artery contains numerous cell types which contribute to multiple vascular diseases. However, the heterogeneity and cellular responses of these vascular cells during abdominal aortic aneurysm (AAA) progression have not been well characterized. METHODS AND RESULTS Single-cell RNA sequencing (scRNA-seq) was performed on the infrarenal abdominal aortas from C57BL/6J mice at days 7 and 14 post-sham or peri-adventitial elastase-induced AAA. Unbiased clustering analysis of the transcriptional ...
3 CitationsSource
#1Haocheng Lu (UM: University of Michigan)H-Index: 8
#2Jifeng Zhang (UM: University of Michigan)H-Index: 36
Last. Minerva T. Garcia-Barrio (UM: University of Michigan)H-Index: 8
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Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Genome-wide association studies (GWAS) are powerful epidemiological tools to find genes and variants associated with cardiovascular diseases while follow-up biological studies allow to better understand the etiology and mechanisms of disease and assign causality. Improved methodologies and reduced costs have allowed wider use of bulk and single-cell RNA sequencing, human-induced pluripotent stem cells, organoids,...
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#1Jun Song (UM: University of Michigan)H-Index: 15
#2Jifeng Zhang (UM: University of Michigan)H-Index: 36
Last. Dongshan Yang (UM: University of Michigan)H-Index: 19
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The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its applications in biomedical research. Novel genome editing technologies, especially CRISPR/Cas9, have remarkably enhanced precise genome manipulation in rabbits, and shown their superiority and promise for...
4 CitationsSource
#1Jun Song (UM: University of Michigan)H-Index: 15
#2Mark J. Hoenerhoff (UM: University of Michigan)H-Index: 18
Last. Jie Xu (UM: University of Michigan)H-Index: 19
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Summary Loss-of-function mutations in the forkhead box N1 (FOXN1) gene lead to nude severe combined immunodeficiency, a rare inherited syndrome characterized by athymia, severe T cell immunodeficiency, congenital alopecia, and nail dystrophy. We recently produced FOXN1 mutant nude rabbits (NuRabbits) by using CRISPR-Cas9. Here we report the establishment and maintenance of the NuRabbit colony. NuRabbits, like nude mice, are hairless, lack thymic development, and are immunodeficient. To demonstra...
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#1Guizhen Zhao (UM: University of Michigan)H-Index: 3
#2Ziyi Chang (UM: University of Michigan)H-Index: 4
Last. Jifeng Zhang (UM: University of Michigan)H-Index: 36
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Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease. Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that Kruppel-like factor 11 (KLF11) plays an essential role in maintaining vascular homeostasis, at least partially through inhibition of EC inflammatory activation. However, the functions of endothelial KLF11 in AAA remain unknown. Here we found that endothelial KLF11 expression was reduced in the ECs from human aneurysms an...
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#1Huilun Wang (UM: University of Michigan)H-Index: 5
#2Yanhong Guo (UM: University of Michigan)H-Index: 26
Last. Y. Eugene Chen (UM: University of Michigan)H-Index: 57
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AIMS Atherosclerosis is the dominant pathologic basis of many cardiovascular diseases. Large genome-wide association studies have identified that single nucleotide polymorphisms proximal to Kruppel-like factor 14 (KLF14), a member of the zinc finger family of transcription factors, are associated with higher cardiovascular risks. Macrophage dysfunction contributes to atherosclerosis development and has been recognized as a potential therapeutic target for treating many cardiovascular diseases. H...
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#1Jinjian Sun (UM: University of Michigan)H-Index: 3
#2Haocheng Lu (UM: University of Michigan)H-Index: 8
Last. Yanbo Fan (UM: University of Michigan)H-Index: 21
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Objective: Vascular endothelial cells (ECs) play a critical role in maintaining vascular homeostasis. Aberrant EC metabolism leads to vascular dysfunction and metabolic diseases. TFEB (transcriptio...
3 CitationsSource