Larry Bodgi
American University of Beirut
Clonogenic assayPhosphorylationPhysicsCancerRadiobiologyBiophysicsInternal medicineDNA repairPathologyOncologyRadiationMolecular biologyBiological systemCytoplasmRadiosensitivityImmunofluorescenceBladder cancerFibroblastNucleusATM ProteinToxicity GradeDsb repairLq modelCancer researchRadiation therapyGeneticsDNARadioresistanceMedicineMathematical modelBiology
23Publications
8H-index
445Citations
Publications 18
Newest
#1Muriel Viau (French Institute of Health and Medical Research)H-Index: 10
#2Anne-Fleur Perez (French Institute of Health and Medical Research)H-Index: 1
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
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Resume L’effet du fractionnement de la dose d’irradiation est une question recurrente qui reste globalement irresolue car aucun modele ne permet aujourd’hui de deduire l’effet clinique par la seule donnee de la dose cumulee et des caracteristiques radiobiologiques des tissus irradies. Cette question importante est abordee differemment en radioprotection, radiotherapie, radiologie ou epidemiologie. Une meilleure comprehension de la reponse moleculaire aux radiations rend aujourd’hui possible une ...
2 CitationsSource
#1Clément Devic (French Institute of Health and Medical Research)H-Index: 9
#2Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
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Resume L’hypersensibilite aux faibles doses de radiations ionisantes (HFD) est un phenomene tres documente caracteristique d’un effet biologique non-lineairement lie a la dose ou a des evenements cellulaires ou moleculaires observes dans une gamme de faibles doses de radiation (generalement entre 1 mGy et 0,8 Gy) sont comparables a ceux observes pour des doses 5 a 50 fois plus fortes. Le phenomene HFD restait jusqu’a aujourd’hui sans explication mecanistique. Depuis 2003, nous avons accumule un ...
Source
#1Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
#2Aurélien Canet (UCBL: Claude Bernard University Lyon 1)H-Index: 3
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
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Abstract Cell survival is conventionally defined as the capability of irradiated cells to produce colonies. It is quantified by the clonogenic assays that consist in determining the number of colonies resulting from a known number of irradiated cells. Several mathematical models were proposed to describe the survival curves, notably from the target theory. The Linear-Quadratic (LQ) model, which is to date the most frequently used model in radiobiology and radiotherapy, dominates all the other mo...
46 CitationsSource
#1Adeline GranzottoH-Index: 9
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
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PURPOSE: Whereas post-radiation therapy overreactions (OR) represent a clinical and societal issue, there is still no consensual radiobiological endpoint to predict clinical radiosensitivity. Since 2003, skin biopsy specimens have been collected from patients treated by radiation therapy against different tumor localizations and showing a wide range of OR. Here, we aimed to establish quantitative links between radiobiological factors and OR severity grades that would be relevant to radioresistan...
62 CitationsSource
#1Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
#2Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
AbstractPurpose For 50 years, cellular radiosensitivity has been defined in vitro as the lack of clonogenic capacity of irradiated cells and its mathematical link with dose has been described by the target theory. Among the numerous formulas provided from the target theory, the linear-quadratic (LQ) model empirically describes cell survival as a negative exponential of a second degree polynomial dose-function in which αD is the linear component and βD2 is the quadratic one. The LQ model is exten...
51 CitationsSource
#1Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
#2Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
5 CitationsSource
Last. Larry BodgiH-Index: 8
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Source
#1Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
#2Adeline Granzotto (French Institute of Health and Medical Research)H-Index: 9
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 10 authors...
Immunofluorescence with antibodies against DNA damage repair and signaling protein is revolutionar- ising the estimation of the genotoxic risk. Indeed, a number of stress response proteins relocalize in nucleus as identifiable foci whose number, pattern and appearance/disappearance rate depend on several parameters such as the stress nature, dose, time and individual factor. Few authors proposed biomathematical tools to describe them in a unified formula that would be relevant for all the reloca...
26 CitationsSource