Larry Bodgi
American University of Beirut
Clonogenic assayPhosphorylationPhysicsCancerRadiobiologyBiophysicsInternal medicineDNA repairPathologyOncologyRadiationMolecular biologyBiological systemCytoplasmRadiosensitivityImmunofluorescenceBladder cancerFibroblastNucleusATM ProteinToxicity GradeDsb repairLq modelCancer researchRadiation therapyGeneticsDNARadioresistanceMedicineMathematical modelBiology
23Publications
8H-index
445Citations
Publications 19
Newest
#1Larry Bodgi (AUB: American University of Beirut)H-Index: 8
#2Hisham F. Bahmad (AUB: American University of Beirut)H-Index: 13
Last. Wassim Abou-Kheir (AUB: American University of Beirut)H-Index: 21
view all 10 authors...
Background: Bladder cancer is the fourth most commonly diagnosed cancer among males worldwide. Current treatment strategies established for bladder cancer mainly consist of cystectomy yet advances in radiation therapy have pointed to the value of organ-preserving strategies in preserving patients’ quality of life. Aim: To study and compare the radiosensitivity in two-dimension (2D) and physiologically-relevant three-dimension (3D) in vitro culture of 3 human bladder cancer cell lines, RT4, T24 a...
8 CitationsSource
#1Mira Maalouf (French Institute of Health and Medical Research)H-Index: 3
#1Mira Maalouf (French Institute of Health and Medical Research)H-Index: 1
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 13 authors...
Purpose Linear energy transfer (LET) plays an important role in radiation response. Recently, the radiation-induced nucleo-shuttling of ATM from cytoplasm to the nucleus was shown to be a major event of the radiation response that permits a normal DNA double-strand break (DSB) recognition and repair. Here, we aimed to verify the relevance of the ATM nucleo-shuttling model for high-LET particles and various radiation types. Methods and Materials ATM- and H2AX-immunofluorescence was used to assess...
5 CitationsSource
#1Hisham F. Bahmad (AUB: American University of Beirut)H-Index: 13
#2Larry Bodgi (AUB: American University of Beirut)H-Index: 8
Last. Wassim Abou-Kheir (AUB: American University of Beirut)H-Index: 21
view all 9 authors...
Introduction Bladder cancer is the fourth most commonly diagnosed cancer among males worldwide. Recent advances in radiation delivery have increased the importance of bladder preserving strategies using radiotherapy, while also improving patient’s quality of life. However, the outcome of radiotherapy depends on the radiosensitivity of both the patient and his/her tumour. Recent developments in radiobiology have highlighted the importance of the assessment of radiation-induced DNA double-strand b...
Source
#1Guillaume Vogin (CNRS: Centre national de la recherche scientifique)H-Index: 14
#2Thierry Bastogne (University of Lorraine)H-Index: 17
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 7 authors...
Purpose The ability to identify, before treatment, those patients who will overreact to radiation therapy would have sound positive clinical implications. By focusing on DNA double-strand breaks recognition and repair proteins after irradiation, we recently demonstrated that the maximal number of phosphorylated ATM (pATM) nuclear foci in the first hour (pATMmax) after ex vivo irradiation correlated with postradiation therapy toxicity severity. We performed additional analyses of our whole collec...
16 CitationsSource
#1Mélanie L. Ferlazzo (French Institute of Health and Medical Research)H-Index: 7
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 11 authors...
The tuberous sclerosis complex (TSC) syndrome is associated with numerous cutaneous pathologies (notably on the face), epilepsy, intellectual disability and developmental retardation and, overall, high occurrence of benign tumors in several organs, like angiofibromas, giant cell astrocytomas, renal angiomyolipomas, and pulmonary lymphangioleiomyomatosis. TSC is caused by mutations of either of the hamartin or tuberin proteins that are mainly cytoplasmic. Some studies published in the 1980s repor...
9 CitationsSource
3 CitationsSource
#1Sandrine Pereira (French Institute of Health and Medical Research)H-Index: 23
#2Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 10 authors...
Purpose To examine the possibility of predicting clinical radiosensitivity by quantifying the nuclear forms of autophosphorylated ATM protein (pATM) via a specific enzyme-linked immunosorbent assay (ELISA). Methods and Materials This study was performed on 30 skin fibroblasts from 9 radioresistant patients and 21 patients with adverse tissue reaction events. Patients were divided into 2 groups: radioresistant (toxicity grade Results The pATM ELISA data were in quantitative agreement with the imm...
23 CitationsSource
#1Alissar El Chediak (AUB: American University of Beirut)H-Index: 7
#2Ali Shamseddine (AUB: American University of Beirut)H-Index: 33
Last. Youssef H. Zeidan (AUB: American University of Beirut)H-Index: 19
view all 6 authors...
Radiation therapy and immunotherapy are two highly evolving modalities for the treatment of solid tumors. Immunotherapeutic drugs can either stimulate the immune system via immunogenic pathways or target co-inhibitory checkpoints. An augmented tumor cell recognition by host immune cells can be achieved post-irradiation, as irradiated tissues can release chemical signals which are sensed by the immune system resulting in its activation. Different strategies combining both treatment modalities wer...
8 CitationsSource
#1Guillaume VoginH-Index: 14
#2Larry BodgiH-Index: 8
Last. Nicolas ForayH-Index: 30
view all 6 authors...
1 CitationsSource
#1Larry Bodgi (French Institute of Health and Medical Research)H-Index: 8
#2Aurélien Canet (French Institute of Health and Medical Research)H-Index: 3
Last. Nicolas Foray (French Institute of Health and Medical Research)H-Index: 30
view all 7 authors...
Resume Le modele lineaire-quadratique (LQ) est aujourd’hui la seule relation mathematique liant la survie cellulaire et la dose de radiation qui soit suffisamment consensuelle pour que radiotherapeutes et radiobiologistes l’utilisent regulierement dans leurs interpretations des phenomenes radioinduits. Pourtant, cette formule proposee dans les annees 1970 et les parametres α et β sur lesquels elle est basee sont restes sans signification biologique coherente. A partir d’une collection de fibrobl...
2 CitationsSource