Augusto Carducci
Sapienza University of Rome
PhosphorylationCell migrationMutantGlycolysisIn vitroImmunologyPlatelet lysateAngiogeninSaccharomyces cerevisiaeKluyveromyces lactisWortmanninYeastAntimycin ABiochemistryCell growthProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biologyProtein kinase A
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#1Augusto Carducci (Sapienza University of Rome)H-Index: 2
#2Gaia Scafetta (Sapienza University of Rome)H-Index: 8
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
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Tenon's fibroblasts (TFs), widely employed as in vitro model for many ophthalmological studies, are routinely cultured with FBS. Platelet Lysate (PL), a hemoderivate enriched with growth factors and cytokines has been largely tested in several clinical applications and as substitute of FBS in culture. Here, we investigate whether PL can exert biological effects on TF populations similarly to other cell types. Results show that PL significantly enhances cell proliferation and migration vs. FBS, w...
8 CitationsSource
#1Samantha Cialfi (Sapienza University of Rome)H-Index: 17
#2Daniela Uccelletti (Sapienza University of Rome)H-Index: 20
Last. Michele Saliola (Sapienza University of Rome)H-Index: 18
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In Saccharomyces cerevisiae, HSL1 (NIK1) encodes a serine-threonine protein kinase involved in cell cycle control and morphogenesis. Deletion of its putative orthologue in Kluyveromyces lactis, KlHSL1, gives rise to sensitivity to the respiratory inhibitor antimycin A (AA). Resistance to AA on glucose (Rag+ phenotype) is associated with genes (RAG) required for glucose metabolism/glycolysis. To understand the relationship between RAG and KlHSL1, rag and Klhsl1Δ mutant strains were investigated. ...
10 CitationsSource