Amir I. Mohamed
Military Medical Academy
CytotoxicityPharmacokineticsCaspase 3Molecular biologyCytotoxic T cellBioavailabilityChemistryApoptosisIn vivoOral administrationChitosanDrug deliveryDrugReactive oxygen speciesPolymerColorectal cancerDosage formAnnexinCompatibility (mechanics)Pharmacology
14Publications
5H-index
63Citations
Publications 13
Newest
#1Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 12
#2Osama A. A. Ahmed (KAU: King Abdulaziz University)H-Index: 9
Last. Ashraf B. Abdel-Naim (KAU: King Abdulaziz University)H-Index: 24
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This study aimed at improving the targeting and cytotoxic effect of ellagic acid (EA) on colon cancer cells. EA was encapsulated in chitosan (CHIT) polymers then coated by eudragit S100 (ES100) microparticles. The release of EA double-coated microparticles (MPs) was tested at simulative pH values. Maximum release was observed at 24 h and pH 7.4. The cytotoxicity of EA MPs on HCT 116 colon cancer cells was synergistically improved as compared with raw EA. Cell-cycle analysis by flow cytometry sug...
9 CitationsSource
#1Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 12
#2Shaimaa M. Badr-Eldin (KAU: King Abdulaziz University)H-Index: 11
Last. Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
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Piceatannol (PIC), a naturally occurring polyphenolic stilbene, has pleiotropic pharmacological activities. It has reported cytotoxic activities against different cancer cells. In the present study, PIC emulsomes (PIC-E) were formulated and assessed for cytotoxic activity. A Box–Behnken design was employed to investigate the influence of formulation factors on particle size and drug entrapment. After optimization, the formulation had a spherical shape with a particle size of 125.45 ± 1.62 nm and...
4 CitationsSource
#1Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 12
#2Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
Last. Amir I. Mohamed (Military Medical Academy)H-Index: 5
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This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h. The efficiency of the double coat to target colonic tissues was confirmed using real-time X-ray radiography of iohexol dye. Entrapment efficiency and particle size were used in the...
7 CitationsSource
#1Nabil A. Alhakamy (KAU: King Abdulaziz University)H-Index: 12
#2Usama A. Fahmy (KAU: King Abdulaziz University)H-Index: 12
Last. Amir I. Mohamed (Military Medical Academy)H-Index: 5
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Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for their potential in drug delivery of cytotoxic agents. Thus, the purpose of this study was to determine the potential enhancement of ICA cytotoxicity activity in OVCAR-3 ovarian cancer cells via its formulation in phytosomes. ICA-phytosomal formulation was optimized us...
12 CitationsSource
#1Mahmoud H. Teaima (Cairo University)H-Index: 3
#2Ahmed M. El Mohamady (Military Medical Academy)
Last. Amir I. Mohamed (Military Medical Academy)H-Index: 5
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Ondansetron HCl is a (5-HT3) serotonin receptor antagonist, used as anti-emetic drug in combination with anticancer agents. Conventional dosage forms have poor bioavailability and patient compliance. These problems can be reduced by the use of nasal niosomal thermo reversible in situ gelling system; Niosomes were formulated using various surfactants (Span 60, Span 80, Tween 20 and Tween 80) in different ratios using thin film hydration technique. Niosomes were evaluated for particle size, zeta p...
Source
#1Amir I. Mohamed (Military Medical Academy)H-Index: 5
#2Amal Abd-Elaal El-Khamery (Military Medical Academy)H-Index: 1
Last. Alaa Ibrahim Mohamed (Cairo University)H-Index: 1
view all 4 authors...
Source
#1Khalid M. El-Say (KAU: King Abdulaziz University)H-Index: 17
#2Osama A. A. Ahmed (KAU: King Abdulaziz University)H-Index: 9
Last. Abdelsattar M. Omar (KAU: King Abdulaziz University)H-Index: 8
view all 5 authors...
Background Premature ejaculation (PE) is the most common type of male sexual disorder with important psychological consequences. Dapoxetine (DPX), a recently approved drug for the treatment of PE, suffers from low bioavailability with large variability that ranges from 15–76% (mean 42%) after oral administration. The objective of this study is to optimize the parameters for the preparation of DPX-Zein-alpha lipoic acid (ALA) nanoparticles (NPs) to improve the bioavailability of DPX and consequen...
3 CitationsSource
The aim of this study was to investigate the effect of various Prosolv® co-processed excipients in the manufacture of different grades of fast melt tablets (FMTs). Caffeine was chosen as a model drug. Caffeine FMTs were prepared by direct compression using Prosolv® based excipients;Prosolv® SMCC 50, Prosolv® SMCC 90,Prosolv® SMCC HD90, Prosolv® ODT, Prosolv®Easytab Nutra,and Prosolv®Easytab SP. Caffeine FMTs were evaluated for weight, thickness, hardness, friability, wetting time (WT), in-vitro ...
Source
#1Amir I. Mohamed (Military Medical Academy)H-Index: 5
#2Amr Mohamed Elsayed Abd-Motagaly (Military Medical Academy)H-Index: 1
Last. Alaa Ibrahim Mohamed Ali (Cairo University)H-Index: 1
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A simple chemometric-assisted UV-spectrophotometric method was used to study the compatibility of clindamycin hydrochloride (HC1) with two commonly used natural controlled-release polymers, alginate (Ag) and chitosan (Ch). Standard mixtures containing 1:1, 1:2, and 1:0.5 w/w drug–polymer ratios were prepared and UV scanned. A calibration model was developed with partial least square (PLS) regression analysis for each polymer separately. Then, test mixtures containing 1:1 w/w drug–polymer ratios ...
13 CitationsSource
#1Amal Abd-Elaal El-Khamery (Military Medical Academy)H-Index: 1
#2Amir I. Mohamed (Military Medical Academy)H-Index: 5
Last. Alaa Ibrahim Mohamed (Cairo University)H-Index: 1
view all 4 authors...
Glaucoma is a serious chronic ophthalmic disease since it causes irreversible visual disability if untreated can lead to blindness. Treatment options include medications (classified into five major classes of drugs which are muscarinic cholinergic agonists, alpha-2 adrenergic agonists, beta-1 adrenergic antagonists, prostaglandins [PGs], and carbonic anhydrase inhibitors); use of laser therapy or conventional surgery. Pharmacoeconomic analysis helps in choosing among this variety of treatments. ...
3 CitationsSource
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