M. B. Zafar
Northwestern University
Transforming growth factorTelomerase reverse transcriptaseReplication (statistics)Viral replicationVirologyOncolytic adenovirusBone metastasisTumor progressionToxicityCancer geneViral vectorCancer researchBreast cancerSignal transductionMedicineOncolytic virusBiology
Publications 3
#10T. Guise (UVA: University of Virginia)H-Index: 41
A modified hTERT promoter-directed oncolytic adenovirus replication with concurrent inhibition of TGFb signaling for breast cancer therapy
#1Zhen-Guo Wang Wang (NorthShore University HealthSystem)
#2Amanda Pister (NorthShore University HealthSystem)H-Index: 3
Last. Prem SethH-Index: 53
view all 5 authors...
Bone metastases are present in most patients with advanced disease and can cause severe morbidity. Transforming growth factor-beta (TGF-beta) plays an important role in the tumor cell-bone interactions resulting in bone destruction. Previously, we have made an oncolytic adenovirus rAd-sTRIIFc, which expresses soluble TGF|[beta]|RIIFc for targeting breast cancer bone metastasis by destroying tumor cells while simultaneously blocking the TGF-beta signaling pathway. To improve specificity in tumor ...
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