M. B. Zafar
Northwestern University
Transforming growth factorTelomerase reverse transcriptaseReplication (statistics)Viral replicationVirologyOncolytic adenovirusBone metastasisTumor progressionToxicityCancer geneViral vectorCancer researchBreast cancerSignal transductionMedicineOncolytic virusBiology
3Publications
1H-index
18Citations
Publications 3
Newest
Source
#10T. Guise (UVA: University of Virginia)H-Index: 41
A modified hTERT promoter-directed oncolytic adenovirus replication with concurrent inhibition of TGFb signaling for breast cancer therapy
Source
#1Zhen-Guo Wang Wang (NorthShore University HealthSystem)
#2Amanda Pister (NorthShore University HealthSystem)H-Index: 3
Last. Prem SethH-Index: 53
view all 5 authors...
Bone metastases are present in most patients with advanced disease and can cause severe morbidity. Transforming growth factor-beta (TGF-beta) plays an important role in the tumor cell-bone interactions resulting in bone destruction. Previously, we have made an oncolytic adenovirus rAd-sTRIIFc, which expresses soluble TGF|[beta]|RIIFc for targeting breast cancer bone metastasis by destroying tumor cells while simultaneously blocking the TGF-beta signaling pathway. To improve specificity in tumor ...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.