Jian Xing Ma
University of Oklahoma Health Sciences Center
Visual phototransductionEndocrinologyWnt signaling pathwayMolecular biologyChemistryVascular endothelial growth factorRetinaRetinal pigment epitheliumNeovascularizationDiabetic retinopathyAngiogenesisRPE65RetinalCancer researchPEDFBiochemistryDiabetes mellitusMedicineBiologyCell biology
Publications 344
#1Paulina Escandon (University of North Texas Health Science Center)
#2Brenda Vasini (University of North Texas Health Science Center)
Last. Dimitrios Karamichos (University of North Texas Health Science Center)H-Index: 16
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Abstract Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors that play essential roles in modulating cell differentiation, inflammation, and metabolism. Three subtypes of PPARs are known: PPAR-alpha (PPARα), PPAR-gamma (PPARγ), and PPAR-beta/delta (PPARβ/δ). PPARα activation reduces lipid levels and regulates energy homeostasis, activation of PPARγ results in regulation of adipogenesis, and PPARβ/δ activation increases fatty acid metabolism and lipolysis. PPARs ...
#1Jianglei ChenH-Index: 4
#2Yan Shao (Tianjin Medical University)H-Index: 6
Last. Jian Xing MaH-Index: 73
view all 8 authors...
Diabetic patients often experience visual defects before any retinal pathologies are detected. The molecular mechanism for the visual defects in early diabetes has not been elucidated. Our previous study reported that in early diabetic retinopathy (DR), rhodopsin levels were reduced due to impaired 11-cis-retinal regeneration. Interphotoreceptor retinol-binding protein (IRBP) is a visual cycle protein and important for 11-cis-retinal generation. IRBP levels are decreased in the vitreous and reti...
#1Harminder Singh (University of Oklahoma Health Sciences Center)H-Index: 2
#2Jian Xing Ma (University of Oklahoma Health Sciences Center)H-Index: 73
Last. Yusuke Takahashi (University of Oklahoma Health Sciences Center)H-Index: 24
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Abstract Dysregulation of Wnt signaling is implicated in multiple ocular disorders. The roles of Wnt co-receptors LRP5 and LRP6 in Wnt signaling regulation remain elusive, as most retinal cells express both of the co-receptors. To address this question, LRP5 and LRP6 were individually knocked-out in a human retinal pigment epithelium cell line using the CRISPR-Cas9 technology. Wnt signaling activity induced by various Wnt ligands was measured using wild-type and the KO cell lines. The results id...
1 CitationsSource
#1Yan Shao (Tianjin Medical University)H-Index: 6
#2Jianglei Chen (University of Oklahoma Health Sciences Center)H-Index: 4
Last. Jian Xing Ma (University of Oklahoma Health Sciences Center)H-Index: 73
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Purpose The retina is a commonly used model for angiogenesis research due to its special characteristics. Oxygen-induced retinopathy (OIR) provides a useful model to study ischemia-induced neovascularization (NV) and to develop anti-angiogenic therapeutics. The purpose of this study was to develop a simple, accurate, and less-subjective quantification method for retinal NV in the OIR model. Methods To address this challenge, we combined the conventional vascular staining and BrdU labeling of new...
#1Zhongxiao Wang (Boston Children's Hospital)H-Index: 15
#2Chi-Hsiu Liu (Boston Children's Hospital)H-Index: 15
Last. Jing Chen (Boston Children's Hospital)H-Index: 45
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Breakdown of the blood-retinal barrier (BRB) causes retinal edema and vision loss. We investigated the role of Wnt signaling in maintaining the BRB by limiting transcytosis. Mice lacking either the Wnt co-receptor low-density lipoprotein receptor-related protein 5 (Lrp5-/- ) or the Wnt ligand Norrin (Ndpy/- ) exhibit increased retinal vascular leakage and enhanced endothelial transcytosis. Wnt signaling directly controls the transcription of an endothelium-specific transcytosis inhibitor, major ...
2 CitationsSource
#1Fangfang Qiu (University of Oklahoma Health Sciences Center)H-Index: 2
#2Xiang Ma (University of Oklahoma Health Sciences Center)H-Index: 2
Last. Jian Xing Ma (University of Oklahoma Health Sciences Center)H-Index: 73
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PURPOSE Elevated blood levels of C-reactive protein (CRP) are associated with both type 1 and type 2 diabetes and diabetic complications, such as diabetic retinopathy (DR). However, its pathogenic role in DR remains unknown. The present study aims to investigate the potential role of CRP in DR pathogenesis and explore its underlying mechanism. MATERIALS AND METHODS Human CRP transgenic (hCRP-Tg) rats were employed for streptozotocin (STZ)-induced diabetic and oxygen-induced retinopathy (OIR) mod...
2 CitationsSource
#1Yanhui Yang (Tianjin Medical University)H-Index: 1
#2Xuemin He (University of Oklahoma Health Sciences Center)H-Index: 1
Last. Jian Xing Ma (University of Oklahoma Health Sciences Center)H-Index: 73
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Kallistatin is an inhibitor of tissue kallikrein and also inhibits the Wnt pathway. Its role in diabetic nephropathy (DN) is uncertain. Here we reported that serum kallistatin levels were significantly increased in diabetic patients with DN compared to those in diabetic patients without DN and healthy controls, and positively correlated with urinary albumin excretion. In addition, renal kallistatin levels were significantly upregulated in mouse models of type 1 (Akita, OVE26) and type 2 diabetes...
1 CitationsSource
#1Di Che (SYSU: Sun Yat-sen University)H-Index: 8
#2Zhenzhen Fang (SYSU: Sun Yat-sen University)H-Index: 3
Last. Ti Zhou (SYSU: Sun Yat-sen University)H-Index: 15
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AIMS/HYPOTHESIS: Diabetes mellitus erectile dysfunction (DMED) is a common complication of diabetes. The level of pigment epithelium-derived factor (PEDF) is significantly upregulated in the serum of individuals with obesity and diabetes. However, whether elevated PEDF levels contribute to DMED remains unknown. This study aimed to investigate the pathogenic role of PEDF and its related mechanism in DMED. METHODS: We enrolled 65 men, of whom 20 were nondiabetic control participants, 21 participan...
1 CitationsSource
#1Xuemin He (University of Oklahoma Health Sciences Center)H-Index: 1
#2Rui Cheng (University of Oklahoma Health Sciences Center)H-Index: 4
Last. Jian Xing Ma (University of Oklahoma Health Sciences Center)H-Index: 73
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Previous studies by us and others demonstrated that activation of Wnt/beta-catenin signaling plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants are reported to associate with autosomal dominant polycystic kidney disease; but their exact roles in this disease and renal fibrosis have not been explored. Here, we observed the upregulation of LRP5 in the renal tubules of both type 1 and type 2 diabetic models and of an obstructive nephropathy model. In the obstruc...
2 CitationsSource
#1Sihao Ye (Ha Tai: Xiamen University)H-Index: 2
#2Qian Chen (Ha Tai: Xiamen University)H-Index: 1
Last. Zuguo Liu (Ha Tai: Xiamen University)H-Index: 30
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Purpose: Pathological neovascularization and fibrosis are common pathological changes of many retinal diseases, such as proliferative retinopathy (PR) and age-related macular degeneration (AMD). Treatment modalities for these pathological changes are limited. The purpose of the present study was to test the effects of palmitoylethanolamide (PEA), an endocannabinoid mimetic amide, on retinal neovascularization and fibrosis and to determine its molecular mechanism of action. Methods: A rat Muller ...
3 CitationsSource