De-ming Liu
Nanchang University
Deubiquitinating enzymeInduced pluripotent stem cellAmniotic stem cellsTelomerase reverse transcriptaseUbiquitin ligaseAmniotic epithelial cellsEmbryoid bodymicroRNAEmbryonic stem cellMolecular biologyGene expression profilingChemistryUbiquitinHypertrophic scarWound healingStem cellIntracellular signal transductionSignal transductionBiologyCell biology
7Publications
4H-index
30Citations
Publications 7
Newest
#1Longxiang Tu (NCU: Nanchang University)H-Index: 2
#2De-ming Liu (NCU: Nanchang University)H-Index: 4
The ubiquitin-proteasome pathway is a protein degradation pathway that relies on ATP and non-lysosomal pathway in eukaryotic cells. It participates in the regulation of multiple biological processes, including cell cycle, apoptosis, DNA repair, antigen presentation, receptor endocytosis, intracellular signal transduction. Recent studies have found that the ubiquitin-proteasome pathway can participate in the formation and development of hypertrophic scar by regulating transforming growth factor b...
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#1Fei-bin Zhu (NCU: Nanchang University)H-Index: 1
#2Xiang-jing FangH-Index: 1
Last. De-ming Liu (NCU: Nanchang University)H-Index: 4
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Exogenous substance P accelerates wound healing in diabetes, but the mechanism remains poorly understood. Here, we established a rat model by intraperitoneally injecting streptozotocin. Four wounds (1.8 cm diameter) were drilled using a self-made punch onto the back, bilateral to the vertebral column, and then treated using amniotic membrane with epidermal stem cells and/or substance P around and in the middle of the wounds. With the combined treatment the wound-healing rate was 100% at 14 days....
5 CitationsSource
#1Pu Ning (NCU: Nanchang University)H-Index: 3
#2Peng Y (NCU: Nanchang University)H-Index: 2
Last. Dewu Liu (NCU: Nanchang University)H-Index: 3
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: MicroRNAs (miRNAs) have recently been shown to play a role in normal wound healing process. miRNAs may be linked to pathologic wound healing and closely related to the formation of hypertrophic scars. This study aimed to explore the effects of tetrandrine on the miRNA expression profile in human hypertrophic scar fibroblasts (HSFs) in vitro. HSFs were randomly divided into two groups: the tetrandrine treatment group and the control group. The experimental and control groups were collected and ...
7 CitationsSource
#1Yong-tie Li (NCU: Nanchang University)H-Index: 2
#2Dewu LiuH-Index: 3
Last. Qun-Hong YuH-Index: 1
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Abstract To investigate the feasibility of differentiation of human induced pluripotent stem cells (iPSCs) into epidermal-like stem cells. (1) Human strain of iPSCs were plated on-to trophoblast of inactivated Fb strain of mouse embryos and cultured in complete medium of embryonic stem cells, iPSCs were subcultured by collagenase IV digestion method. The morphology and growth of iPSCs were observed under inverted phase contrast microscope, and the cells were stained with alkaline phosphatase (AK...
3 Citations
#1Pu Ning (NCU: Nanchang University)H-Index: 3
#2Dewu Liu (NCU: Nanchang University)H-Index: 6
Last. De-ming LiuH-Index: 4
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Objective To explore the miRNA differential expression profiles of hyperplastic scar and normal skin so as to further elucidate the pathogenesis of hyperplastic scar and search for new theraputic targets.Methods The total RNA was extracted from 5 human hyperplastic scar and normal skin tissues by Trizol.The specimens were collected from the First Affiliated Hospital of Nanchang University from November 2010 to May 2011,and purified by mirVanaTM miRNA Isolation Kit and then labeled and hybridized...
9 CitationsSource
#1Dewu Liu (NCU: Nanchang University)H-Index: 6
#2Lianqun Wang (NCU: Nanchang University)H-Index: 3
Last. Wei Lan (NCU: Nanchang University)H-Index: 2
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6 CitationsSource
#1Dewu Liu (NCU: Nanchang University)H-Index: 6
#2Lianqun Wang (NCU: Nanchang University)H-Index: 3
Last. Wei Lan (NCU: Nanchang University)H-Index: 2
view all 7 authors...
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