Yu Li
Jilin University
PhosphorylationInternal medicineMicrosomal triglyceride transfer proteinEndocrinologyChemistryPeroxisome proliferator-activated receptorApoptosisOxidative stressHepatocyteAMP-activated protein kinaseMalondialdehydeFatty liverNEFAUric acidLipoproteinAMPKCarbohydrate-responsive element-binding proteinLipid oxidationLipid metabolismReactive oxygen speciesBiochemistryOxidative phosphorylationSignal transductionVery low-density lipoproteinBiologyCell biologyProtein kinase A
16Publications
8H-index
325Citations
Publications 16
Newest
#1Peng Z (JLU: Jilin University)
#1Zhiyu PengH-Index: 22
Last. Gang LiuH-Index: 49
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Innate immune suppression and high blood fatty acid levels are the pathological basis of multiple metabolic diseases. Neutrophil vacuolation is an indicator of the immune status of patients, which is associated with autophagy-dependent granule degradation. Vacuolated neutrophils are observed in ethanol toxicity and septicemia patients due to the changes in their blood constituents, but how about the neutrophils in nonalcoholic fatty liver disease (NAFLD) patient is unknown. Here, we confirmed th...
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#1Yu Li (AAU: Anhui Agricultural University)H-Index: 8
#2Hongyan Ding (AAU: Anhui Agricultural University)H-Index: 7
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 13 authors...
Elevated plasma nonesterified fatty acid (NEFA) levels and hepatocytes damage are characteristics of ketosis in dairy cows. Oxidative stress is associated with the pathogenesis of NEFA-induced liver damage. However, the exact mechanism by which oxidative stress mediates NEFA-induced hepatocytes apoptosis and liver injury remains poorly understood. The results of the present study demonstrated that NEFA contribute to reactive oxygen species (ROS) generation, resulting in an imbalance between oxid...
9 CitationsSource
#1Yu Cao (JLU: Jilin University)H-Index: 4
#2Juxiong Liu (JLU: Jilin University)H-Index: 11
Last. Shoupeng Fu (JLU: Jilin University)H-Index: 19
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Previous studies have shown the effects of vitamins on the development of the mammary gland. However, the role of niacin in this process has not been reported. Therefore, the aim of this study was to investigate the effects of niacin on mammary gland development in pubertal mice and to use a mouse mammary epithelial cell line to study the underlying mechanism. The results showed that niacin could activate the AKT/mTOR and ERK signaling pathways by the Gi protein-coupled receptor and increase pho...
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#1Yu Li (AAU: Anhui Agricultural University)H-Index: 8
#2Hongyan Ding (AAU: Anhui Agricultural University)H-Index: 7
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 11 authors...
: The ketotic cows displayed hepatic lipid metabolic disorder and high blood concentration of glucagon. Importantly, adenosine monophosphate-activated protein kinase (AMPK) signaling pathway plays an important role in the hepatic lipid homeostasis. Therefore, the aim of this study was to investigate the effect of glucagon on AMPK pathway and its underlying mechanism on lipid metabolism in cow hepatocytes. Cow hepatocytes were cultured and treated with glucagon and AMPK inhibitor (BML-275). The r...
6 CitationsSource
#1Xuedong Ding (AAU: Anhui Agricultural University)H-Index: 3
#2Manman Li (AAU: Anhui Agricultural University)H-Index: 3
Last. Jinchun Li (AAU: Anhui Agricultural University)H-Index: 6
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Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice. Despite evidence suggesting that chicken renal proximal tubular epithelial cells participate in uric acid secretion, the roles of BCRP and MRP4 in chickens remain unclear. This study evaluated the relationship between chicken BCRP and MRP4 expression and renal function in the liver, kidneys, and intestines. Sixty 20-day-old Isa brown laying hens were randomly ...
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#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Yu Li (AAU: Anhui Agricultural University)H-Index: 8
Last. Xiaobing Li (JLU: Jilin University)H-Index: 22
view all 10 authors...
Dairy cows with type II ketosis display hepatic fat accumulation and hyperinsulinemia, but the underlying mechanism is not completely clear. This study aimed to clarify the regulation of lipid metabolism by insulin in cow hepatocytes. In vitro, cow hepatocytes were treated with 0, 1, 10, or 100 n m insulin in the presence or absence of AICAR (an AMP-activated protein kinase alpha (AMPKα) activator). The results showed that insulin decreased AMPKα phosphorylation. This inactivation of AMPKα incre...
6 CitationsSource
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Qiushi Xu (JLU: Jilin University)H-Index: 6
Last. Xiaobing Li (JLU: Jilin University)H-Index: 22
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Background The natural incidence of left displacement of abomasum (LDA) in dairy cows was high. The diagnosis of LDA usually relies on characteristic physical exam findings but that transabdominal ultrasound is a useful technique that has been applied to the diagnosis of gastrointestinal diseases of dairy cows in equivocal cases.
3 CitationsSource
#1Yu Li (JLU: Jilin University)H-Index: 8
#2Hong Ding (AAU: Anhui Agricultural University)H-Index: 19
Last. Li Xiao (JLU: Jilin University)H-Index: 2
view all 8 authors...
Summary The aim of this study was to evaluate the oxidative status in ketotic cows. We observed changes in the oxidative status and correlations between the oxidative and metabolic status in non-ketotic (n = 10), subclinical ketotic (n = 10) and ketotic cows (n = 10). Plasma samples were analysed by standard biochemical techniques and ELISA to determine traditional metabolic parameters: triglyceride (TG), phosphonium (P), calcium (Ca), aspartate aminotransferase (AST), alanine aminotransferase (...
32 CitationsSource
#1Qinghua Deng (JLU: Jilin University)H-Index: 8
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
β-hydroxybutyric acid (BHBA), an important metabolite in β-oxidation, is involved in the development of ketosis in dairy cows. It is known that AMP-activated protein kinase (AMPK) signaling pathway plays an important role in the regulation of lipid metabolism in hepatocytes. In the present study, bovine hepatocytes were treated with BHBA at variable concontrations and Compound C (Cpd C, an AMPK inhibitor) to investigate the effects of BHBA on the AMPK signaling pathway. The results showed that w...
19 CitationsSource
#1Xiaoxia Shi (JLU: Jilin University)H-Index: 8
#2Dangdang Li (JLU: Jilin University)H-Index: 3
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 11 authors...
Abstract Non-esterified fatty acids (NEFAs) are important induction factors of inflammatory responses in some metabolic diseases. High plasma levels of NEFAs and oxidative stress exist in the dairy cows with ketosis. The aim of this study was to investigate whether high levels of NEFAs can induce inflammatory response and the specific molecular mechanism in the hepatocytes of dairy cow. In vitro , primary cultured bovine hepatocytes were treated with different concentrations of NEFAs, PDTC (an N...
53 CitationsSource