Christian M. Becker
University of Oxford
Genome-wide association studyBiobankInternal medicineObstetricsEndocrinologyGenomePathologyOdds ratioChemistryInfertilityDiseaseEndometriosisPelvic painUterine fibroidsGynecologyCancer researchGeneticsBioinformaticsMedicineBiomarker (medicine)BiologyPeritoneal fluid
Publications 97
#1Lysia Demetriou (University of Oxford)H-Index: 10
#2Emma CoxH-Index: 1
Last. Elaine Fox (University of Oxford)H-Index: 47
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Endometriosis is a chronic condition affecting ~10% of women globally. Little is known about the impact of the coronavirus disease 2019 (COVID-19) pandemic on their care. This brief report explores the impact of COVID-19 on the care of people with endometriosis around the world, their priorities in relation to their clinical care during and post the pandemic; and whether they believed endometriosis increases vulnerability to COVID-19. An internet-based survey study collected data in 5 languages ...
#2Moamar Al-JefoutH-Index: 11
Last. Nilufer RahmiogluH-Index: 21
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#1Thomas Tapmeier (John Radcliffe Hospital)H-Index: 1
#2Nilufer Rahmioglu (University of Oxford)H-Index: 21
Last. Ronald A. Harris (BCM: Baylor College of Medicine)H-Index: 6
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Endometriosis is a common chronic inflammatory condition causing pelvic pain and infertility in women, with limited treatment options and 50% heritability. We leveraged genetic analyses in two species with spontaneous endometriosis, humans and the rhesus macaque, to uncover treatment targets. We sequenced DNA from 32 human families contributing to a genetic linkage signal on chromosome 7p13-15 and observed significant overrepresentation of predicted deleterious low-frequency coding variants in N...
2 CitationsSource
#1Eeva Sliz (University of Oulu)H-Index: 5
#2Jaakko S Tyrmi (University of Oulu)H-Index: 3
Last. Johannes Kettunen (University of Oulu)H-Index: 49
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Uterine leiomyomata (UL) are the most common benign tumours of the female genital tract with an estimated lifetime incidence of up to 70%. To date, 7 genome-wide association studies have identified 35 loci predisposing to UL. To improve the understanding of the underlying genetic pathways, we conducted the largest genetic association study of UL to date in 426,558 European women from FinnGen and a previously published UL meta-GWAS. We identified 36 novel and replicated 31 previously reported loc...
#1Alexandros Loukas Grammatis (University of Oxford)
#2Ektoras X. Georgiou (Princess Anne Hospital)H-Index: 7
Last. Christian M. Becker (University of Oxford)H-Index: 19
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Background null Endometriosis is a chronic inflammatory condition that occurs during the reproductive years. It is characterised by endometrium-like tissue developing outside the uterine cavity. This endometriotic tissue development is dependent on oestrogen produced primarily by the ovaries and partially by the endometriotic tissue itself, therefore traditional management has focused on ovarian suppression. In this review we considered the role of modulation of the immune system as an alternati...
#1A Grammatis (Barts Health NHS Trust)
Last. Christian M. Becker (University of Oxford)H-Index: 19
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#1Christian M. Becker (John Radcliffe Hospital)H-Index: 19
#2J Kotarski (Medical University of Lublin)
Last. Sawsan As-Sanie (UM: University of Michigan)H-Index: 19
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#1Sawsan As-Sanie (UM: University of Michigan)H-Index: 19
#2Linda C. Giudice (UCSF: University of California, San Francisco)H-Index: 113
Last. Qurratul Ann WarsiH-Index: 1
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#1Venkatesh Ss (University of Oxford)
#2Teresa Ferreira (University of Oxford)H-Index: 44
Last. Wittemans Lbl (University of Oxford)
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Background: Obesity is observationally associated with altered risk of many female reproductive conditions. These include polycystic ovary syndrome (PCOS), abnormal uterine bleeding, endometriosis, infertility, and pregnancy-related disorders. However, the roles and mechanisms of obesity in the aetiology of null reproductive disorders remain unclear. Methods and Findings: We estimated observational and genetically predicted causal associations between obesity, metabolic hormones, and female repr...
#1Prasanna Raj Supramaniam (John Radcliffe Hospital)H-Index: 3
#2Ingrid Granne (University of Oxford)H-Index: 9
Last. Monica Mittal (Imperial College Healthcare)H-Index: 4
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STUDY QUESTION: Does the method of fertilisation improve reproductive outcomes in poor ovarian response (POR) cycles when compared to all other ovarian response categories in the absence of male factor subfertility? SUMMARY ANSWER: ICSI does not confer any benefit in improving the clinical pregnancy or live birth (LB) outcome in autologous ovarian response cycles in the absence of male factor subfertility when compared to IVF. WHAT IS KNOWN ALREADY: ICSI is associated with an improved outcome wh...
7 CitationsSource