Milad Bastami
Tabriz University of Medical Sciences
GeneCancerInternal medicineDownregulation and upregulationPeripheral blood mononuclear cellOncologymicroRNAGene expressionSingle-nucleotide polymorphismAlleleImmunologyCoronary artery diseasePathogenesisGenotypingCancer researchObesityBreast cancerCarcinogenesisBioinformaticsMedicineBiologyMeta-analysisCancer cell
58Publications
12H-index
465Citations
Publications 57
Newest
#1Milad Bastami (Tabriz University of Medical Sciences)H-Index: 12
#2Habibollah Mahmoodzadeh (Tehran University of Medical Sciences)H-Index: 10
Last. Ziba Nariman-Saleh-Fam (Tabriz University of Medical Sciences)H-Index: 12
view all 7 authors...
BACKGROUND Esophageal Cancer is known as one of the deadliest cancers worldwide with the squamous cell carcinoma (ESCC) being the predominant subtype. There is a growing body of evidence linking the dysregulated microRNA (miRNA) pathway of immune cells to the progression of several tumors. In a previous study, we investigated molecular alterations pertaining to miR-146a and some components of NF-kB signaling pathway and proposed a possible immune downregulatory mechanism in peripheral blood mono...
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#1Milad BastamiH-Index: 12
#2Andrea Masotti (Boston Children's Hospital)H-Index: 31
Last. Ziba Nariman-Saleh-Fam (Tabriz University of Medical Sciences)H-Index: 12
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Abstract null null MicroRNAs (miRNAs) have emerged as a critical component of regulatory networks that modulate and fine-tune gene expression in a post-transcriptional manner. The microRNA-196 family is encoded by three loci in the human genome, namely hsa-mir-196a-1, hsa-mir-196a-2, and hsa-mir-196b. Increasing evidence supports the roles of different components of this miRNA family in regulating key cellular processes during differentiation and development, ranging from inflammation and differ...
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OBJECTIVE Breast cancer (BC) is the most significant and lethal type of cancer in women. Although there are many newly develop chemotherapy drugs for patients with BC treating at various stages, drug resistance is the most important obstacle in their effectiveness for BC treatment. On the other hand, microRNAs are considered key regulators of genes involved in carcinogenesis and chemoresistance in cancers. The purpose of this study was to evaluate the role of miR-152-3p and miR-185 in intrinsic ...
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#1Hosein Mansoori (Shiraz University of Medical Sciences)H-Index: 1
#2Farzaneh Darbehesht (Tehran University of Medical Sciences)
Last. Sedigheh Tahmasebi (Shiraz University of Medical Sciences)H-Index: 8
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Abstract A growing amount of evidence has revealed that long noncoding RNAs (lncRNAs) play significant roles in malignancies through different mechanisms especially the competing endogenous RNA (ceRNA). They have also been shown to have the potential diagnostic, prognostic and therapeutic biomarker capacity in oncology research. Recently, lncRNA Alu-mediated p21 transcriptional regulator (APTR) has been proposed as an oncogenic lncRNA in development and clinical outcome of some cancers. However,...
1 CitationsSource
#1Abdolreza Daraei (Babol University of Medical Sciences)H-Index: 9
#2Pantea Izadi (Tehran University of Medical Sciences)H-Index: 12
Last. Javad Tavakkoly-Bazzaz (Tehran University of Medical Sciences)H-Index: 12
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Abstract Although little is known regarding the mechanisms behind the onset of breast cancer (BC) through reproductive risk factors, new researches have highlighted some early tumor-related methylation footmarks in the breast tissue of apparently clinically healthy women as their potential epigenetic mechanism. Previous evidence supports that the estrogen receptor beta (ER-β), whose anti-cancer roles had already been revealed in BC, is downregulated in the breasts of healthy nulliparous women. N...
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#1Soheila Delgir (Tabriz University of Medical Sciences)H-Index: 3
#2Milad Bastami (Tabriz University of Medical Sciences)H-Index: 12
Last. Mohammad Reza Alivand (Tabriz University of Medical Sciences)H-Index: 11
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Abstract Breast cancer (BC) is a heterogeneous cancer with multiple subtypes affecting women worldwide. Triple-negative breast cancer (TNBC) is a prominent subtype of BC with poor prognosis and an aggressive phenotype. Recent understanding of metabolic reprogramming supports its role in the growth of cancer cells and their adaptation to their microenvironment. The Warburg effect is characterized by the shift from oxidative to reductive metabolism and external secretion of lactate. The Warburg ef...
2 CitationsSource
#1Khandan Ilkhani (Tabriz University of Medical Sciences)H-Index: 3
#2Soheila Delgir (Tabriz University of Medical Sciences)H-Index: 3
Last. Mohammad Reza Alivand (Tabriz University of Medical Sciences)H-Index: 11
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Background Breast cancer (BC) is the most common malignancy among women with a high mortality rate. The blockade of asparagine-related pathways may be an effective measurement to control the progression and reduction of BC metastasis potential. Recently, it has been shown that various miRNAs, as part of small non-coding RNAs, have a great role in cancer development, especially asparagine-related pathways, to modulate the invasiveness. Objective This study aimed to evaluate the expression of miR-...
2 CitationsSource
#1Asma Safi (Tabriz University of Medical Sciences)H-Index: 4
#2Milad Bastami (Tabriz University of Medical Sciences)H-Index: 12
Last. Mohammad Reza Alivand (Tabriz University of Medical Sciences)H-Index: 11
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Cisplatin has a broad-spectrum antitumor activity and is widely used for the treatment of various malignant tumors. However, acquired or intrinsic resistance of cisplatin is a major problem for patients during the therapy. Recently, it has been reported Cancer Stem Cell (CSC)-derived drug resistance is a great challenge of tumor development and recurrence; therefore, the sensitivity of Breast Cancer Stem Cells (BCSCs) to cisplatin is of particular importance. Increasing evidence has shown that t...
2 CitationsSource
#1Soheila Delgir (Tabriz University of Medical Sciences)H-Index: 3
#2Khandan Ilkhani (Tabriz University of Medical Sciences)H-Index: 3
Last. Mohammad Reza Alivand (Tabriz University of Medical Sciences)H-Index: 11
view all 9 authors...
BACKGROUND Breast cancer (BC) is the most invasive cancer with different subtypes that its metabolism is unique compared with normal cells. Glutamine is considered critical nutrition that many cancer cells, particularly BC cells, are dependent on it for growth and proliferation. Therefore, targeting glutamine metabolism, especially enzymes that are related to this pathway, can be beneficial to design anti-cancer agents. Recent evidence has shown that microRNAs (miRNAs), with a short length and s...
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#1Khandan Ilkhani (Tabriz University of Medical Sciences)H-Index: 3
#2Milad Bastami (Tabriz University of Medical Sciences)H-Index: 12
Last. Mohammad Reza Alivand (Tabriz University of Medical Sciences)H-Index: 11
view all 6 authors...
Metabolic reprogramming is a significant property of various cancer cells, which most commonly arises from the Tumor Microenvironment (TME). The events of metabolic pathways include the Warburg effect, shifting in Krebs cycle metabolites, and the rate of oxidative phosphorylation, potentially providing energy and structural requirements for the development and invasiveness of cancer cells. TME and tumor metabolism shifting have a close relationship through bidirectional signaling pathways betwee...
5 CitationsSource