Jeff Ji
McGill University
Colloidal goldExcitatory postsynaptic potentialNeuriteBiophysicsInternal medicineTFEBEndocrinologyGene expressionNanoparticleNeurotrophic factorsSmall moleculeControlled releaseNeuroscienceAdipose tissueNanotechnologyDendritic spineNanocarriersAqueous solutionLiposomeChemistryNanostructureCell typePostsynaptic potentialAutophagyLipid dropletSelf-assemblyMechanism of actionAmyloid betaLAMP2Primary (chemistry)ThioketalEthylene glycolHyaluronic acidAstrocyteBuffer solutionCurcuminConfocal microscopyChitosanDrug deliveryMicrogliaContext (language use)NeurogliaNeural cellDrug encapsulationFunctional statusGenetically engineeredNanosensorChemical engineeringLipid metabolismBiomoleculePolymersomePolymerCentral nervous systemHomeostasisAmphiphileCrosstalk (biology)BiologyNeuroinflammationNeurotrophinCell biology
9Publications
6H-index
86Citations
Publications 9
Newest
#1Parinaz Sabourian (McGill University)H-Index: 3
#2Jeff Ji (McGill University)H-Index: 6
Last. Ashok K. Kakkar (McGill University)H-Index: 43
view all 8 authors...
Easily assembled and biocompatible chitosan/hyaluronic acid nanoparticles with multiple stimuli-responsive ability are ideally suited for efficient delivery of therapeutic agents under specific endogenous triggers. We report a simple and versatile strategy to formulate oxidative stress and pH-responsive chitosan/hyaluronic acid nanocarriers with high encapsulation efficiencies of small drug molecules and nerve growth factor protein. This is achieved through invoking the dual role of a thioketal-...
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#1Dusica Maysinger (McGill University)H-Index: 63
#2Mélanie Lalancette-Hébert (Laval University)H-Index: 18
Last. Jasna Kriz (Laval University)H-Index: 33
view all 8 authors...
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#1Dusica Maysinger (McGill University)H-Index: 63
#2Jeff Ji (McGill University)H-Index: 6
: Biological and synthetic nanostructures can influence both glia and neurons in the central nervous system. Neurons represent only a small proportion (about 10%) of cells, whereas glial cells are the most abundant cell types. Non-targeted nanomedicines are mainly internalized by glia, in particular microglia, and to a lesser extent by astrocytes. Internalized nanomedicines by glia indirectly modify the functional status of neurons. The mechanisms of biochemical, morphological and functional cha...
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#1Alexandre Moquin (McGill University)H-Index: 12
#2Jessica Sturn (McGill University)H-Index: 1
Last. Ashok K. Kakkar (McGill University)H-Index: 43
view all 8 authors...
Amphiphilic architectural polymers of tunable compositions self-assemble into soft nanoparticles of varied stability that is dependent on the number of poly(ethylene glycol) tails. Cryo-electron microscopy- and freeze-fracture-technique-based evaluations of their internal structure display morphologies unlike those of conventional block-copolymer-based micelles, with a uniform and homogeneous composition that strongly influences drug-specific encapsulation and release characteristics. The subera...
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#1Jeff Ji (McGill University)H-Index: 6
#2Maria Petropavlovskaia (McGill University)H-Index: 8
Last. Dusica Maysinger (McGill University)H-Index: 63
view all 7 authors...
: Both type 2 diabetes (T2D) and obesity are characterized by excessive hyperlipidaemia and subsequent lipid droplet (LD) accumulation in adipose tissue. To investigate whether LDs also accumulate in β-cells of T2D patients, we assessed the expression of PLIN2, a LD-associated protein, in non-diabetic (ND) and T2D pancreata. We observed an up-regulation of PLIN2 mRNA and protein in β-cells of T2D patients, along with significant changes in the expression of lipid metabolism, apoptosis and oxidat...
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#1Jeff Ji (McGill University)H-Index: 6
#2Alexandre Moquin (McGill University)H-Index: 12
Last. Dusica Maysinger (McGill University)H-Index: 63
view all 8 authors...
AbstractGold nanoparticles (AuNP) have unique physicochemical properties and have been used as delivery vehicles, contrast agents, and therapeutic compounds. Although the effects of AuNPs on periph...
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#1Alexandre Moquin (McGill University)H-Index: 12
#2Jeff Ji (McGill University)H-Index: 6
Last. Dusica Maysinger (McGill University)H-Index: 63
view all 5 authors...
Polymersomes are attractive nanocarriers for hydrophilic and lipophilic drugs; they are more stable than liposomes, tunable, and relatively easy to prepare. The copolymer composition and molar mass are critical features that determine the physicochemical properties of the polymersomes including the rate of drug release. We used the triblock-copolymer, poly(2-methyl-2-oxazoline)-block-poly-(dimethysiloxane)-block-poly(2-methyl-2-oxazoline) (PMOXA–PDMS–PMOXA), to form amphipathic polymersomes capa...
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#1Dusica Maysinger (McGill University)H-Index: 63
#2Jeff Ji (McGill University)H-Index: 6
Last. Gerhard Multhaup (McGill University)H-Index: 17
view all 15 authors...
Dendritic polyglycerols (dPG), particularly dendritic polyglycerol sulfates (dPGS), have been intensively studied due to their intrinsic anti-inflammatory activity. As related to brain pathologies involving neuroinflammation, the current study examined if dPG and dPGS can (i) regulate neuroglial activation, and (ii) normalize the morphology and function of excitatory postsynaptic dendritic spines adversely affected by the neurotoxic 42 amino acid amyloid-β (Aβ42) peptide of Alzheimer disease (AD...
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#1Dusica Maysinger (McGill University)H-Index: 63
#2Jeff Ji (McGill University)H-Index: 6
Last. Elis Cooper (McGill University)H-Index: 1
view all 4 authors...
Nanotechnology, a rapidly evolving field, provides simple and practical tools to investigate the nervous system in health and disease. Among these tools are nanoparticle-based probes and sensors that detect biochemical and physiological properties of neurons and glia, and generate signals proportionate to physical, chemical, and/or electrical changes in these cells. In this context, quantum dots (QDs), carbon-based structures (C-dots, graphene and nanodiamonds) and gold nanoparticles are the mos...
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