Ayeeshik Kole
Indiana University
Internal medicineRadiologyBiomedical engineeringPathologyUltrasoundMaterials scienceAcoustic waveIn vivoEx vivoArteryIntravascular ultrasoundCoronary artery diseaseModality (human–computer interaction)CatheterPreclinical imagingUltrasound imagingPerivascular fatMiniature swineFrame rateComputer sciencePhotoacoustic imaging in biomedicineMedicineImage processing
37Publications
7H-index
576Citations
Publications 17
Newest
#1Ayeeshik Kole (IU: Indiana University)H-Index: 7
#2Yingchun Cao (Purdue University)H-Index: 13
Last. Michael Sturek (IU: Indiana University)H-Index: 62
view all 7 authors...
Intravascular photoacoustic-ultrasound (IVPA-US) imaging and near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) are two hybrid modalities that detect arterial lipid, with comparison necessary to understand the relative advantages of each. We performed in vivo and ex vivo IVPA-US imaging of the iliac arteries of Ossabaw swine with metabolic syndrome (MetS) and lean swine to investigate sensitivity for early-stage atherosclerosis. We repeated imaging ex vivo with NIRS-IVUS for compari...
8 CitationsSource
#1Yingchun Cao (BU: Boston University)H-Index: 13
#2Ayeeshik Kole (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 7
Last. Ji-Xin Cheng (BU: Boston University)H-Index: 83
view all 5 authors...
With a quasi-collinear imaging catheter and functional sheath material, we successfully implemented intravascular photoacoustic tomography for in vivo imaging of rabbit aorta, with localization and quantification analysis of lipid distribution in arterial walls.
Source
#1Ayeeshik Kole (IU: Indiana University)H-Index: 7
#2Yingchun Cao (Purdue University)H-Index: 13
Last. Michael Sturek (IU: Indiana University)H-Index: 62
view all 7 authors...
Current imaging tools lack sensitivity and depth resolution to accurately quantify lipid core content at different stages of disease. Here, we present an intravascular catheter which can produce co-registered images of morphology and depth-resolved lipid core content via ultrasound and photoacoustic
Source
#1Jill K. Badin (IU: Indiana University)H-Index: 3
#2Ayeeshik Kole (IU: Indiana University)H-Index: 7
Last. Michael Sturek (IU: Indiana University)H-Index: 62
view all 7 authors...
Background There is a preponderance of evidence implicating diabetes with increased coronary artery disease (CAD) and calcification (CAC) in human patients with metabolic syndrome (MetS), but the effect of diabetes on CAD severity in animal models remains controversial. We investigated whether diabetes exacerbates CAD/CAC and intracellular free calcium ([Ca2+]i) dysregulation in the clinically relevant Ossabaw miniature swine model of MetS.
8 CitationsSource
#1Yingchun Cao (Purdue University)H-Index: 13
#2Ayeeshik Kole (IU: Indiana University)H-Index: 7
Last. Ji-Xin ChengH-Index: 83
view all 8 authors...
Intravascular photoacoustic tomography is an emerging technology for mapping lipid deposition within an arterial wall for the investigation of the vulnerability of atherosclerotic plaques to rupture. By converting localized laser absorption in lipid-rich biological tissue into ultrasonic waves through thermoelastic expansion, intravascular photoacoustic tomography is uniquely capable of imaging the entire arterial wall with chemical selectivity and depth resolution. However, technical challenges...
34 CitationsSource
#1Ayeeshik KoleH-Index: 7
#1Yingchun Cao (Purdue University)H-Index: 13
#2Ayeeshik Kole (Purdue University)H-Index: 7
Last. Ji-Xin Cheng (Purdue University)H-Index: 83
view all 7 authors...
Recent advances in atherosclerotic plaque detection have shown that not only does lipid core size and depth play important roles in plaque rupture and thrombi formation, but lipid composition, especially cholesterol deposition, is equally important in determining lesion vulnerability. Here, we demonstrate a spectral analysis assisted photoacoustic imaging approach to differentiate and map lipid compositions within an artery wall. The approach is based on the classification of spectral curves obt...
14 CitationsSource
#1Jie Hui (Purdue University)H-Index: 9
#2Yingchun Cao (Purdue University)H-Index: 13
Last. Ji-Xin Cheng (Purdue University)H-Index: 83
view all 10 authors...
Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipid-laden plaques, as it provides simultaneous morphological and lipid-specific chemical information of an artery wall. Real-time imaging and display at video-rate speed are critical for clinical utility of the IVPA-US imaging technology. Here, we demonstrate a portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging ...
44 CitationsSource
#1Mikaela L. McKenney-Drake (IU: Indiana University)H-Index: 6
#2Stacey D. Rodenbeck (IU: Indiana University)H-Index: 3
Last. Michael Sturek (IU: Indiana University)H-Index: 62
view all 8 authors...
Background Pericoronary epicardial adipose tissue (cEAT) serves as a metabolic and paracrine organ that contributes to inflammation and is associated with macrovascular coronary artery disease (CAD) development. Although there is a strong correlation in humans between cEAT volume and CAD severity, there remains a paucity of experimental data demonstrating a causal link of cEAT to CAD. The current study tested the hypothesis that surgical resection of cEAT attenuates inflammation and CAD progress...
19 CitationsSource
#1Jie Hui (Purdue University)H-Index: 9
#2Yingchun Cao (Purdue University)H-Index: 13
Last. Ji-Xin Cheng (Purdue University)H-Index: 83
view all 10 authors...
Intravascular photoacoustic-ultrasound (IVPA-US) imaging is an emerging hybrid modality for the detection of lipidladen plaques by providing simultaneous morphological and lipid-specific chemical information of an artery wall. The clinical utility of IVPA-US technology requires real-time imaging and display at speed of video-rate level. Here, we demonstrate a compact and portable IVPA-US system capable of imaging at up to 25 frames per second in real-time display mode. This unprecedented imaging...
2 CitationsSource