For people with metabolic syndrome (MetS), altering the macronutrient composition of their diets might ameliorate metabolic abnormalities. The common method of clinical assessment only measures total lipid concentrations but ignores the individual species that contribute to these total concentrations. Thus, to predict the amelioration of MetS following caloric restriction (CR) and the intake of fish oil, we used lipidomics to investigate changes in plasma lipids and identify potential lipid meta...
#1Hsiu Chuan Lee(TMU: Taipei Medical University)H-Index: 6
#2Yun-Chun Lo(TMU: Taipei Medical University)H-Index: 1
Last. Shih Yi Huang(TMUH: Taipei Medical University Hospital)H-Index: 25
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AbstractThis study explored the effects of the degree of lipid saturation on depressive behaviour and gut microbiota in mice. Thirty-two mice were divided into normal (N), Prozac (NP), lard (L) and...
#2Yu-Chuan Chien(PRC: China Medical University (PRC))H-Index: 3
Last. Kuan-Pin Su(PRC: China Medical University (PRC))H-Index: 31
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Abstract Objective Circadian dysfunction is a core manifestation and a risk factor for psychiatric disorders. Ramelteon (RMT), a melatonin receptor agonist, has been shown to induce sleep phase shifts and has been used to normalize sleep onset time. RMT has been used in sleep disorders, depression and anxiety. In this study, we aimed to investigate the effects of RMT in regulating gene expression profiles of the circadian clock and peripheral markers of inflammation and neuroplasticity. Methods ...
Summary Background & aims Haptoglobin (Hp) is associated with risks of obesity and cardiometabolic dysfunction; however, the role of the Hp phenotype in diet-induced weight loss remains to be elucidated. This study investigated whether the Hp phenotype contributes to inter-individual variations in body weight reduction as well as changes in the metabolic profile. Methods Secondary data analysis from a randomized controlled trial. In total, 151 abdominally obese Taiwanese women with ≥2 metabolic ...
Last. Hui-Yu Huang(Shih Chien University)H-Index: 18
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Summary Background & aims Emerging evidence indicates that gut microbiota serves an important role in the development and progression of chronic kidney disease (CKD). Changes to the gut microbial flora can cause the generation of uremic toxins, which contribute to chronic kidney injury. The aim of the current study was to explore the clinical association between metabolites and CKD. Methods Between August 2013 and January 2015, a two-phase case–control study was conducted to analyze the clinical...
#1Te-Hsuan Tung(TMU: Taipei Medical University)H-Index: 2
#2Yu Tang Tung(TMU: Taipei Medical University)H-Index: 25
Last. Shih Yi Huang(TMU: Taipei Medical University)H-Index: 25
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Background: This study investigated the effects of fish oil and olive oil in improving dysbiosis and depressive-like symptoms. Methods and results: Male rats were fed normal, fish oil-rich or olive oil-rich diets for 14 weeks. Chronic mild stress (CMS) was administered from week 2. The sucrose preference test (SPT) and forced swimming test (FST) were used to determine depressive-like behavior. The SPT results revealed that the CMS, CMS with imipramine (CMS+P) treatment, and CMS with olive oil di...