Hong Jiang
Max Planck Society
Insulin receptorNeuropeptideInternal medicineEndocrinologyVascular endothelial growth factor AChemistryNeurotransmissionEnergy homeostasisMelanin-concentrating hormoneHypothalamusOrexigenicInsulin resistanceNeuronMedian eminenceInsulinCerebrospinal fluidLateral hypothalamusCell metabolismNormal dietGlucose homeostasisCell activationOptogeneticsEffectorHormonePI3K/AKT/mTOR pathwayBiologyCell biology
Publications 3
#1Hong Jiang (MPG: Max Planck Society)H-Index: 3
#2Sarah Gallet (university of lille)H-Index: 6
Last. Jens C. BrüningH-Index: 84
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Summary Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity to tanycytes and fenestrated vessels. Chemogenetic activation of MCH neurons as well as optogenetic stimulation of their projections in the ME enhance permeability of the ME by increasing fenestrated vascular loops and enhance leptin action in the arcuate nucleus of the hypothal...
6 CitationsSource
#1Hong Jiang (MPG: Max Planck Society)H-Index: 3
#2Jens C. Brüning (MPG: Max Planck Society)H-Index: 84
In contrast to synaptic transmission, the mechanism of volume transmission—in which neurotransmitters or neuropeptides diffuse to many effector cells—is not extensively investigated, although it represents an important mode of neuronal communication. In this issue of Cell Metabolism, Noble et al. (2018) demonstrate how the orexigenic melanin-concentrating hormone (MCH) controls feeding behavior through cerebrospinal fluid (CSF) volume transmission.
4 CitationsSource
#1A. Christine Hausen (MPG: Max Planck Society)H-Index: 5
#2Johan Ruud (MPG: Max Planck Society)H-Index: 6
Last. Jens C. BrüningH-Index: 84
view all 7 authors...
Summary Melanin-concentrating-hormone (MCH)-expressing neurons (MCH neurons) in the lateral hypothalamus (LH) are critical regulators of energy and glucose homeostasis. Here, we demonstrate that insulin increases the excitability of these neurons in control mice. In vivo, insulin promotes phosphatidylinositol 3-kinase (PI3K) signaling in MCH neurons, and cell-type-specific deletion of the insulin receptor (IR) abrogates this response. While lean mice lacking the IR in MCH neurons (IR ΔMCH ) exhi...
33 CitationsSource