Amar U. Kishan
University of California, Los Angeles
CancerInternal medicineRadiologyUrologySurgeryMagnetic resonance imagingOncologyRandomized controlled trialExternal beam radiotherapyProstateBiochemical recurrenceBrachytherapyAndrogen deprivation therapyDiseaseProstatectomyProstate cancerNuclear medicineStereotactic body radiotherapyRadiation therapyMedicine
Publications 211
Although cancer is highly heterogeneous, all metastatic cancer is considered American Joint Committee on Cancer (AJCC) Stage IV disease. The purpose of this project was to redefine staging of metastatic cancer. Internal validation of nationally representative patient data from the National Cancer Database (n = 461 357; 2010-2013), and external validation using the Surveillance, Epidemiology and End Results database (n = 106 595; 2014-2015) were assessed using the concordance index for evaluation...
#1William A. Hall (MCW: Medical College of Wisconsin)H-Index: 26
#2Eric S. Paulson (MCW: Medical College of Wisconsin)H-Index: 21
Last. Clifton D. FullerH-Index: 53
view all 13 authors...
Radiation therapy (RT) continues to play an important role in the treatment of cancer. Adaptive RT (ART) is a novel method through which RT treatments are evolving. With the ART approach, computed tomography or magnetic resonance (MR) images are obtained as part of the treatment delivery process. This enables the adaptation of the irradiated volume to account for changes in organ and/or tumor position, movement, size, or shape that may occur over the course of treatment. The advantages and chall...
#1Michael Xiang (UCLA: University of California, Los Angeles)H-Index: 14
#2Albert J. Chang (UCLA: University of California, Los Angeles)H-Index: 22
Last. Amar U. Kishan (UCLA: University of California, Los Angeles)H-Index: 22
view all 7 authors...
ABSTRACT null null Introduction null : Use of hypofractionated radiation (HFRT) and intensity-modulated radiation (IMRT) for organ preservation in bladder cancer is controversial and highly variable. We investigated practice patterns, trends, and predictors of HFRT and IMRT. null null null Patients and Methods null : The National Cancer Database was queried for patients with muscle-invasive, non-metastatic urothelial bladder cancer, treated with definitive (chemo)radiotherapy between 2004-2017. ...
#1Ting Martin Ma (UCLA: University of California, Los Angeles)H-Index: 10
#2Soumyajit Roy (Rush University Medical Center)
Last. Amar U. Kishan (UCLA: University of California, Los Angeles)H-Index: 22
view all 27 authors...
Background and purpose null The Phoenix definition for biochemical failure (BCF) after radiotherapy uses nadir PSA (nPSA)+2ng/mL to classify a BCF and was derived from conventionally fractionated radiotherapy, which produces significantly higher nPSAs than stereotactic body radiotherapy (SBRT). We investigated whether an alternative nPSA-based threshold could be used to define post-SBRT BCFs. null Materials and methods null PSA kinetics data on 2038 patients from 9 institutions were retrospectiv...
#1Yi Lao (UCLA: University of California, Los Angeles)H-Index: 9
#2Minsong Cao (UCLA: University of California, Los Angeles)H-Index: 21
Last. Ke Sheng (UCLA: University of California, Los Angeles)H-Index: 32
view all 7 authors...
PURPOSE To introduce a novel surface-based dose mapping method to improve quantitative bladder dosimetric assessment in prostate cancer (PC) radiotherapy. METHODS Based on the planning and daily pre and postfraction MRIs of 12 PC patients, bladder surface models (SMs) were generated on manually delineated contours and regionally aligned via surface-based registration. Subsequently, bladder surface dose models (SDMs) were created using face-wise dose sampling. To determine the bladder intrafracti...
#5Sara M Garrett (Penn State Cancer Institute)
#10Amar U. Kishan (UCLA: University of California, Los Angeles)H-Index: 22
PURPOSE/OBJECTIVE(S) Staging for metastatic disease is unreliable; there is usually only one category of Stage IV in the American Joint Commission on Cancer (AJCC) 8th edition, but survival can range from weeks to years. We hypothesize that prognostication can be improved for metastatic disease by using common clinical covariates in a pan-cancer phenotype staging system. MATERIALS/METHODS Latent class analysis was performed to explore the phenotypes using nationally representative patient data f...
#1Rachel GlicksmanH-Index: 7
#2Amar U. KishanH-Index: 22
Last. Andrew LoblawH-Index: 37
view all 10 authors...
#1Luca F. Valle (UCLA: University of California, Los Angeles)H-Index: 8
#2Eric J. Lehrer (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 15
Last. Amar U. Kishan (UCLA: University of California, Los Angeles)H-Index: 22
view all 17 authors...
Abstract Context Management of locally recurrent prostate cancer after definitive radiotherapy remains controversial due to the perceived high rates of severe genitourinary (GU) and gastrointestinal (GI) toxicity associated with any local salvage modality. Objective To quantitatively compare the efficacy and toxicity of salvage radical prostatectomy (RP), high-intensity focused ultrasound (HIFU), cryotherapy, stereotactic body radiotherapy (SBRT), low–dose-rate (LDR) brachytherapy, and high-dose...
#1Tommy JiangH-Index: 4
#2Daniela MarkovicH-Index: 26
Last. David ElashoffH-Index: 79
view all 13 authors...
#1Neil R. ParikhH-Index: 4
Last. James Lamb (UCLA: University of California, Los Angeles)H-Index: 17
view all 11 authors...
Background and Purpose Stereotactic body radiation therapy (SBRT) has become a standard-of-care option for localized prostate cancer. While prostate SBRT has traditionally been delivered using computed-tomography-guided radiation therapy (CTgRT), MR-imaging-guided radiation therapy (MRgRT) is now available. MRgRT offers real-time soft-tissue visualization and ease of adaptive planning, obviating the need for fiducial markers, and potentially allowing for smaller planning target volume (PTV) marg...
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