De-An Guo
Chinese Academy of Sciences
CytotoxicityPharmacognosyMass spectrometryOrganic chemistryHigh-performance liquid chromatographyChemistryGlycosideHeLaBiotransformationTandem mass spectrometryElectrospray ionizationChromatographyBiochemistryTraditional medicineBotanyLiquid chromatography–mass spectrometryStereochemistryMedicineBiologyPharmacology
511Publications
68H-index
11.5kCitations
Publications 497
Newest
#1Haijuan Zhi (CAS: Chinese Academy of Sciences)H-Index: 4
#2Zijia Zhang (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Jinjun Hou (CAS: Chinese Academy of Sciences)H-Index: 17
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Abstract null null Salvianolic acids have a special synergic effect on panax notoginsenosides in acute myocardial infarction (AMI) and have been developed into a new drug as Danqi Tongmai Tablet (DQTT). To explore candidate targets and mechanisms of DQTT on AMI, a network pharmacology-based analysis was performed on absorbed prototype compounds of DQTT in rat plasma. Target prediction from network analysis indicated that the arachidonic acid pathway might contribute to the therapeutic effects of...
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Huashi Baidu prescription (HSBDF), recommended in the Guideline for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Pneumonia (On Trials, the Seventh Edition), was clinically used to treat severe corona virus disease 2019 (COVID-19) with cough, blood-stained sputum, inhibited defecation, red tongue etc. symptoms. This study was aimed to elucidate and profile the knowledge on its chemical constituents and the potential anti-inflammatory effect in vitro. In the study, the chemical con...
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#1Ling Chen (Nanjing University of Chinese Medicine)
#2Changliang Yao (CAS: Chinese Academy of Sciences)H-Index: 17
Last. De-An Guo (CAS: Chinese Academy of Sciences)H-Index: 68
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Comprehensive characterization of traditional Chinese medicine prescriptions has long been a hurdle due to the chemical complexity and the lack of analytical tools. Mahuang decoction is a well-known traditional Chinese medicine prescription widely used for sweating and relieving the exterior, relieving cough and asthma, but it was insufficiently chemically scrutinized. In this study, the chemical component information of Mahuang decoction was investigated by ultrahigh performance liquid chromato...
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#1Shuguang Guan (Changchun University)H-Index: 1
#2Qiaoli Pu (Changchun University)
Last. De-an Guo (Changchun University)
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Crocins are highly valuable natural compounds for treating human disorders, and they are also high-end spices and colorants in the food industry. Due to the limitation of obtaining this type of highly polar compound, the commercial prices of crocins I and II are expensive. In this study, macroporous resin column chromatography combined with high-speed counter-current chromatography (HSCCC) was used to purify crocins I and II from natural sources. With only two chromatographic steps, both compoun...
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#1Mengzhen Cheng (CAS: Chinese Academy of Sciences)
#2Changliang Yao (CAS: Chinese Academy of Sciences)H-Index: 17
Last. De-An Guo (CAS: Chinese Academy of Sciences)H-Index: 68
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Authentication of Chinese medicine materials in prescriptions is extremely difficult due to the complicated chemical matrix. A strategy integrating in-depth profiling, chemical marker selection, and selected detection was established and exemplarily applied to authenticate paeony root in ShaoYao-GanCao decoction. Firstly, an ultra-performance LC/linear trap quadrupole-Orbitrap method was developed to probe the chemical compositions of the decoction. Secondly, 20 batches of decoctions prepared fr...
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#1Wenlong Wei (CAS: Chinese Academy of Sciences)H-Index: 4
#2Zhenwei Li (CAS: Chinese Academy of Sciences)H-Index: 5
Last. De-An Guo (CAS: Chinese Academy of Sciences)H-Index: 68
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Abstract Ginsenoside Rg1 (Rg1) was one of the dominent active components in several Panax medicinal species as Panax notoginseng and P. ginseng with diversified bioactivities. However, the study on tissue distribution of Rg1 remained limited and needs to be further explored for elucidation of its spatial distribution. In the present study, a LC-MS/MS combined with nanospray desorption electrospray ionization (DESI) mass spectrometry method was developed for exploration of tissue distribution of ...
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#1Ya-ling An (CAS: Chinese Academy of Sciences)H-Index: 1
#2Wenlong Wei (CAS: Chinese Academy of Sciences)H-Index: 4
Last. De-An Guo (CAS: Chinese Academy of Sciences)H-Index: 68
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Abstract The inherent complexity of traditional Chinese medicines necessitates the application of multi-dimensional information to accomplish comprehensive profiling and confirmative identification of their chemical components. In this study, we display an enhanced strategy by integrating offline superimposed two-dimensional separation (S-2D-LC) with mass defect filter and diagnostic ion filter to comprehensively characterize the alkaloid composition of Fritillariae Pallidiflorae Bulbus (FPB). T...
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#1Changliang Yao (CAS: Chinese Academy of Sciences)H-Index: 17
#2Jing Wang (CAS: Chinese Academy of Sciences)H-Index: 11
Last. De-An Guo (CAS: Chinese Academy of Sciences)H-Index: 68
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Due to the high price and limited supply of Panax notoginseng, a large number of samples adulterated with the leaves appear in the market. A group of new malonyl ginsenosides were exclusively detected in the P. notoginseng leaves (PNL). Targeted isolation of the malonyl ginsenosides was guided by UPLC-QDa MS. HRMS, 1D/2D NMR, and chemical methods were used for structural identification. A selected ion monitoring method was developed based on UPLC-QDa MS to detect the adulterations. In addition, ...
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#1Shuai Yao (CAS: Chinese Academy of Sciences)H-Index: 15
#2Jianqing Zhang (CAS: Chinese Academy of Sciences)H-Index: 3
Last. De-An Guo (CAS: Chinese Academy of Sciences)H-Index: 68
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Abstract In this study, a high performance thin-layer chromatography/single quadrupole mass spectrometry QDa (HPTLC-QDa) method for robust authentication of Ganoderma lucidum, a popular and valuable herbal medicine, has been developed. This method is simple and practical, which allows direct generation of characteristic mass spectra from the HPTLC plates automatically with the application of in situ solvent desorption interface. The HPTLC silica gel plates were developed with toluene-ethyl forma...
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#1Xia Wang (CAS: Chinese Academy of Sciences)H-Index: 4
#1Xia Wang (CAS: Chinese Academy of Sciences)H-Index: 23
Last. De-An Guo (CAS: Chinese Academy of Sciences)H-Index: 68
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INTRODUCTION: Liuwei Dihuang Pills (concentrated pills, simplified as LWDHP), one of the most famous classic Chinese Patent Medicine (CPM), is produced by hundreds of pharmaceutical manufacturers with billions of Chinese yuan (CNY) in annual sales. However, current quality identification of LWDHP mainly relies on a thin-layer chromatography (TLC) method that is complicated and deficient. OBJECTIVE: The goal of this study is to simplify the identification process and provide a more comprehensive ...
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