Shengqiang Tong
Zhejiang University of Technology
Proton NMREnantioselective synthesisAqueous two-phase systemStability constants of complexesOrganic chemistryHigh-performance liquid chromatographyChemistryCountercurrent exchangeMandelic acidCyclodextrinMethanolEthyl acetateTriethylamineSolvent systemChiral ligandChromatographyPhase (matter)Extraction (chemistry)EnantiomerColumn chromatographyCountercurrent chromatographyElutionResolution (mass spectrometry)
73Publications
14H-index
650Citations
Publications 74
Newest
#1Hengmian Sun (Zhejiang University of Technology)
#2Li-Juan Ma (UM: University of Macau)H-Index: 5
Last. Shengqiang Tong (Zhejiang University of Technology)H-Index: 14
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The minor ginsenosides with less polarity from Panax notoginseng leaves may have more potent biological activities. Four minor saponins, i.e. gypenoside XVII, ginsenoside Rd2, notoginsenoside Fe and notoginsenoside Fd, were successfully separated from Panax notoginseng leaves after biotransformation by one-step counter-current chromatography using the biphasic solvent system consisting of n-butanol-ethyl acetate-water (1:4:5, v/v/v). 30 mg of the refined extract of Panax notoginseng leaves produ...
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#1Yi Tao (Zhejiang University of Technology)H-Index: 5
#2Lin Chen (Zhejiang University of Technology)H-Index: 1
Last. Jizhong Yan (Zhejiang University of Technology)H-Index: 15
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To avoid stationary phase irreversibly adsorption and tedious and time-consuming separation steps, high-speed counter-current chromatography was employed for the preparative separation of anti-tumor compound antroquinonol from solid fermentation culture of Antrodia camphorata for the first time. A Box-Behnken experimental design, based on three parameters including liquid-to-solid ratio, extraction time and extraction temperature, was applied to optimize the ultrasonic extraction procedure. The ...
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#1Chaoyue Wang (Zhejiang University of Technology)H-Index: 5
#2Xingchu Gong (ZJU: Zhejiang University)H-Index: 18
Last. Shengqiang Tong (Zhejiang University of Technology)H-Index: 14
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In the pharmacopoeia, many process parameters for the purification process of Scutellariae Radix are unclear. In this study, deterministic screening design combined with design space method was used to optimize the purification process of Scutellariae Radix extract. Nine method parameters such as mass fraction of solution(X_1), first acid precipitation pH(X_2) and first holding time(X_3) in the purification process were firstly studied by definitive screening design. The yield of baicalin was de...
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#1Honglei Bao (Zhejiang University of Technology)
#2Wenyu Sun (Zhejiang University of Technology)H-Index: 5
Last. Shengqiang Tong (Zhejiang University of Technology)H-Index: 14
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Abstract Maslinic acid and corosolic acid with high purity were successfully separated from Eriobotrya japonica (Thunb.) leaves by two-step countercurrent chromatographic separation. Two biphasic solvent systems composed of petroleum ether-ethyl acetate-ethanol-water (6:4:5:5, v/v) and petroleum ether-ethyl acetate-ethanol-0.10 mol/L of hydroxypropyl-β-cyclodextrin with pH 7.0 (8:2:3.5:6.5, v/v) were selected according to the partition performance of the main structural isomeric pentacyclic trit...
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#1Shanshan Zhao (Zhejiang University of Technology)H-Index: 4
#2Xiang Wang (Zhejiang University of Technology)H-Index: 4
Last. Shengqiang Tong (Zhejiang University of Technology)H-Index: 14
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A method for quantitative determination of the main active ingredient in traditional Chinese medicine was developed and validated, using liquid-liquid chromatography combined with high performance ...
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#1Fu Lulu (Zhejiang University of Technology)H-Index: 2
#2Chenghua Lu (Zhejiang University of Technology)H-Index: 1
Last. Wei-Guang Shan (Zhejiang University of Technology)H-Index: 15
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Five non-polar phloroglucinol derivatives, viz. pseudo-aspidin, α-kosin and agripinol A-C were isolated and purified from Agrimonia pilosa Ledeb by semi-preparative counter-current chromatography. The separation was performed by a two-step elution with non-aqueous solvent systems. In the first step, an elution mode of a two-phase solvent system consisting of n-hexane-acetonitrile-dichloromethane-methanol (6:6:0.5:0.5, v/v/v/v) was used. We obtained sample Ι containing three components (47.0 mg) ...
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#1Yang Jin (Zhejiang University of Technology)H-Index: 4
#2Honglei Bao (Zhejiang University of Technology)
Last. Shengqiang Tong (Zhejiang University of Technology)H-Index: 14
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2-(4-Chlorophenyl)succinic acid was successfully enantioseparated by countercurrent chromatography using hydroxypropyl-β-cyclodextrin as chiral selector. A two-phase solvent system composed of n-hexane-ethyl acetate-0.1 mol/L phosphate buffer with pH 2.65 (5:5:10, v/v) was selected. Enantioselective liquid-liquid extraction was used to optimize the enantioseparation conditions. Meanwhile, the influence of injection volume on resolution in countercurrent chromatography was investigated and a line...
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#1Yang Jin (Zhejiang University of Technology)H-Index: 4
#2Honglei Bao (Zhejiang University of Technology)
Last. Shengqiang Tong (Zhejiang University of Technology)H-Index: 14
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2-(3-Methylphenyl)propanic acid and 2-(4-methylphenyl)propanoic acid were successfully enantioseparated by countercurrent chromatography using hydroxypropyl-β-cyclodextrin (HP-β-CD) as a chiral selector. 2-(2-Methylphenyl)propanoic acid was also studied to compare the enantioseparation ability of three isomeric 2-(methylphenyl)propanoic acids. Totally 20 mg of 2-(3-methylphenyl)propanic acid and 20mg of 2-(4-methylphenyl)propanic acid were enantioseparated individually by countercurrent chromato...
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#1Wenyu Sun (Zhejiang University of Technology)H-Index: 5
#2Honglei Bao (Zhejiang University of Technology)
Last. Shengqiang Tong (Zhejiang University of Technology)H-Index: 14
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Ondansetron, a highly selective 5-hydroxytryptamine 3 receptor antagonist, was successfully enantioseparated by recycling countercurrent chromatography using sulfobutyl ether-β-cyclodextrin as chiral selector. Important factors for the enantioseparation were optimized, including different organic solvent, type of substituted β-cyclodextrin, pH of aqueous phase, concentration of chiral selector and separation temperature. A biphasic solvent system composed of n-hexane: n-butyl acetate: 0.1 mol L-...
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#1Hui Zhang (Zhejiang University of Technology)H-Index: 3
#2Cong Xu (Zhejiang University of Technology)H-Index: 3
Last. Jizhong Yan (Zhejiang University of Technology)H-Index: 15
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Abstract Ethnopharmacological relevance Shenqi Jiangtang granule (SJG) is an ancient Chinese herbal formula used for treatment of Diabetes mellitus and its complications. Aim of the study To establish an integrated approach for discovery of effective Aldose reductase inhibitors (ARIs) from SJG. Materials and methods An integrated approach combining ultrafiltration-liquid chromatography-mass spectrometry (UF-LC-MS) with in silico molecular docking was established for development of ARIs. AR enzym...
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