Masao Hashimoto
Kumamoto University
Internal medicineRadiologySurgeryMutantCTL*Cytotoxic T cellVirologyCD8Human leukocyte antigenT-cell receptorEpitopeImmunologyLung cancerBronchial thermoplastyRespiratory failureLungPneumoniaSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Uncontrolled asthmaAnesthesiaMutationMedicinePulmonary function testingBiologyGastroenterology
35Publications
8H-index
386Citations
Publications 35
Newest
#1Akinari TsukadaH-Index: 1
#2Manabu SuzukiH-Index: 5
Last. Haruhito SugiyamaH-Index: 19
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We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few SARS-CoV-2 antigen-positive ce...
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#1Gen YamadaH-Index: 41
#2Kayoko HayakawaH-Index: 16
Last. Norio OhmagariH-Index: 24
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Abstract Introduction Most of the currently used prognostic models for COVID-19 are based on Western cohorts, but it is unknown whether any are applicable to patients with COVID-19 in Japan. Methods This retrospective cohort study included 160 patients with COVID-19 who were admitted to the National Center for Global Health and Medicine between January 26, 2020 and July 25, 2020. We searched PubMed for prognostic models for COVID-19. The predicted outcome was initiation of respiratory support or...
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#1Kei YamamotoH-Index: 7
#2Sho SaitoH-Index: 7
Last. Norio OhmagariH-Index: 24
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Real-time reverse transcription polymerase chain reaction (RT-PCR) tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are occasionally repeated when clinicians suspect false-negative results, but the conditions under which repeated RT-PCR testing is warranted remain unclear. We evaluated the practice of repeat RT-PCR testing for SARS-CoV-2 in 45 patients who were retested after an initial negative PCR test. Of these, the diagnosis of coronavirus disease (COVID-19) was confirm...
1 CitationsSource
#1Yoshie TsujimotoH-Index: 2
#2Junko TeradaH-Index: 1
Last. Haruhito SugiyamaH-Index: 19
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BACKGROUND: The current gold standard in coronavirus disease (COVID-19) diagnostics is the real-time reverse transcription-polymerase chain reaction (RT-PCR) assay for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasopharyngeal swab (NPS) samples. Alternatively, nasal swab (NS) or saliva swab (SS) specimens are used, although available data on test accuracy are limited. We examined the diagnostic accuracy of NPS/NS/SS samples for this purpose. METHODS: Ten patien...
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#2Manabu SuzukiH-Index: 5
Last. Haruhito SugiyamaH-Index: 19
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A 62-year-old woman with rheumatoid arthritis and a history of receiving immunosuppressant therapy had a recurrence of lung adenocarcinoma with EGFR L858R mutation. Following 14 months of treatment with erlotinib, computed tomography (CT) findings revealed the presence of small diffuse nodules. Bronchoscopy was performed as metastasis was suspected; however, this was not detected on lung biopsy with forceps. Transbronchial lung cryobiopsy (TBLC) succeeded in detecting metastatic adenocarcinoma, ...
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#1Hiroshi TakumidaH-Index: 2
#2Shinyu IzumiH-Index: 19
Last. Masayuki HojoH-Index: 11
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Abstract A 70-year-old Japanese man contracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and required oxygen to maintain oxygen saturation (>90%), 5 weeks after onset of coronavirus disease 2019 (COVID-19) symptoms. Transbronchial lung cryobiopsy revealed pathological features of organizing pneumonia with alveolar epithelial injury, and prednisolone administration led to alleviation of respiratory symptoms and recovery of respiratory function. This case report is the...
1 CitationsSource
#1Masaya SugiyamaH-Index: 34
#2Noriko KinoshitaH-Index: 6
Last. Masashi MizokamiH-Index: 97
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COVID-19, a novel coronavirus-related illness, has spread worldwide. Patients with apparently mild/moderate symptoms can suddenly develop severe pneumonia. Therefore, almost all COVID-19 patients require hospitalization, which can reduce limited medical resources in addition to overwhelming medical facilities. To identify predictive markers for the development of severe pneumonia, a comprehensive analysis of serum chemokines and cytokines was conducted using serial serum samples from COVID-19 pa...
8 CitationsSource
#1Satoru IshiiH-Index: 6
#2Hiromu WatanabeH-Index: 1
Last. Haruhito SugiyamaH-Index: 19
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OBJECTIVE New flex-rigid pleuroscope enables observations with a maximum angle of curvature of 180° , allowing visualization of the area near the insertion site of the pleuroscope. And, it improved the image quality and channel inner diameter. The aim of this study was to evaluate the clinical effectiveness and safety of a new flex-rigid pleuroscope. METHODS A retrospective analysis of patients who were examined with a new flex-rigid pleuroscope under local anesthesia at our institution was cond...
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#2Motoyasu IikuraH-Index: 21
Last. Masao HashimotoH-Index: 8
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Bronchial thermoplasty (BT) is an interventional endoscopic treatment for severe bronchial asthma. Some studies have shown the clinical efficacy of this intervention, but its cost-effectiveness is unclear. The aim of this study was to evaluate the cost-effectiveness of BT. We collected data from the medical records of 16 Japanese patients who were treated with BT between February 2015 and April 2017, and compared asthma-related medical expenses between the year preceding and the year following B...
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OBJECTIVE: To evaluate the efficacy and safety of direct hemoperfusion using a polymyxin B-immobilized polystyrene column (PMX-DHP) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pneumonia patients. METHODS: This study was a case series conducted at a designated infectious diseases hospital. Twelve SARS-CoV-2-positive patients with partial pressure of arterial oxygen/percentage of inspired oxygen (P/F) ratio < 300 were treated with PMX-DHP on two consecutive days each d...
1 CitationsSource