Sukanya Bhunia
Texas A&M University
Gene silencingDrug carrierCellMolecular biologyRNA interferenceDNA vaccinationNanotechnologyGene knockdownMetal-organic frameworkCovalent bondLiposomeChemistryApoptosisMaterials scienceIn vitroIn vivoSmall interfering RNASystemic administrationNipecotic acidNeuroblastomaPaclitaxelMelanomaInfiltration (medical)GliomaBlood–brain barrierBrain tumorGrowth inhibitionDrug deliveryNACAFlexibility (engineering)Cell cycleCancer therapyModular compositionStructural frameworkAnti angiogenicComputer scienceCancer researchAmino acidMedicineBiologyCancer cellPharmacology
9Publications
5H-index
186Citations
Publications 6
Newest
#1Shreedevi Arun Kumar (A&M: Texas A&M University)H-Index: 3
#2Bhuvaneshwari Balasubramaniam (IITK: Indian Institute of Technology Kanpur)H-Index: 5
Last. Akhilesh K. Gaharwar (A&M: Texas A&M University)H-Index: 55
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Two-dimensional (2D) metal organic frameworks (MOFs), are an emerging class of layered nanomaterials with well-defined structure and modular composition. The unique pore structure, high flexibility, tunability, and ability to introduce desired functionality within the structural framework, have led to potential use of MOFs in biomedical applications. This article critically reviews the application of 2D MOFs for therapeutic delivery, tissue engineering, bioimaging, and biosensing. Further, discu...
6 CitationsSource
#1Sukanya Bhunia (A&M: Texas A&M University)H-Index: 5
#2Kaivalya A. Deo (A&M: Texas A&M University)H-Index: 2
Last. Akhilesh K. Gaharwar (A&M: Texas A&M University)H-Index: 55
view all 3 authors...
38 CitationsSource
#1Poulami Majumder (Indian Institute of Chemical Technology)H-Index: 4
#2Sukanya Bhunia (Indian Institute of Chemical Technology)H-Index: 5
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
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Limited tumor tissue penetration is one of the key impeding factors retarding successful in vivo exploitations of anti-angiogenic cancer therapy. Herein we report on the design of a cell penetrating peptide-decorated lipid nano-assembly which, upon systemic administration, induces significant mouse tumor growth inhibition via enhanced tumor infiltration of encapsulated anti-angiogenic siRNA.
25 CitationsSource
#1Sukanya Bhunia (Indian Institute of Chemical Technology)H-Index: 5
#2Venugopal Vangala (Indian Institute of Chemical Technology)H-Index: 2
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
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Despite significant progress in neurosurgery and radiation therapy during the past decade, overall survivability (OS) of glioblastoma patients continues to be less than 2 years. The scope of systemic chemotherapy is greatly limited by poor drug transport across the blood brain barrier (BBB) and, thereby, suboptimal drug accumulation in glioma tissue. To this end, use of large amino acid transporter-1 (LAT1) overexpressed both on brain capillary endothelial cells (BCECs) and glioma cells has begu...
24 CitationsSource
#1Sukanya Bhunia (Indian Institute of Chemical Technology)H-Index: 5
#2Vegesna Radha (CCMB: Centre for Cellular and Molecular Biology)H-Index: 25
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
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Despite significant recent progress in the area of translational genomics of neuroblastoma, the overall survival rates for children with high-risk NB continue to be not more than 5 years due to tumor relapse and/or drug-resistant tumors. Herein we report on the development of a neuroblastoma targeting nanometric (130–150 nm) circulation stable liposomal system prepared from a novel nipecotic acid-derived cationic amphiphile (NACA). The size ranges of liposomes (130–150 nm) were confirmed by both...
16 CitationsSource
#1Poulami Majumder (Indian Institute of Chemical Technology)H-Index: 4
#2Sukanya Bhunia (Indian Institute of Chemical Technology)H-Index: 5
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
view all 4 authors...
Abstract Many cancer cells over express CDC20 (Cell Division Cycle homologue 20), a key cell cycle regulator required for the completion of mitosis in organisms from yeast to human. A recent in vitro study showed that specific knockdown of CDC20 expression using CDC20siRNA can significantly inhibit growth of human pancreatic carcinoma cells. However, preclinical study aimed at demonstrating therapeutic potential of CDC20siRNA in inhibiting tumor growth has just begun. Using a syngeneic C57BL/6 J...
38 CitationsSource