Siru Zhou
Shanghai Jiao Tong University
P70-S6 Kinase 1EndocrinologyCellular differentiationDental alveolusConditional gene knockoutBone remodelingChemistryOsteoclastRUNX2Bone mineralOsteoblastSTAT3Bone marrowSignal transductionBone resorptionOvariectomized ratTranscription factorPI3K/AKT/mTOR pathwayBiologyCell biology
13Publications
7H-index
136Citations
Publications 13
Newest
#1Yueyang HongH-Index: 3
#2Hongyuan XuH-Index: 2
Last. Lingyong JiangH-Index: 8
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#1Xinyi Gong (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Xiangru HuangH-Index: 2
Last. Lingyong JiangH-Index: 8
view all 8 authors...
#1Yiling YangH-Index: 4
#2Qianye ChenH-Index: 1
Last. Lingyong JiangH-Index: 8
view all 8 authors...
Transgenic mouse models are powerful for understanding the critical genes controlling osteoclast differentiation and activity, and for studying mechanisms and pharmaceutical treatments of osteoporosis. Cathepsin K (Ctsk)-Cre mice have been widely used for functional studies of osteoclasts. The signal transducer and activator of transcription 3 (STAT3) is relevant in bone homeostasis, but its role in osteoclasts in vivo remains poorly defined. To provide the in vivo evidence that STAT3 participat...
1 CitationsSource
#1Hongyuan Xu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Siru Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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OBJECTIVES: Alveolar bone osteoporosis has attracted more and more attention because of its profound impact on stomatognathic function and treatment, but current treatments have not been targeted to alveolar bone and might even cause severe side effects. Thus, identifying the effects of anti-osteoporosis agents on alveolar bone is essential. Icariin ameliorates metabolic dysfunction of long bones, but its effects on alveolar bone remain unclarified. MATERIALS AND METHODS: BMSCs were isolated fro...
6 CitationsSource
#1Yiling Yang (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Mi Ri Chung (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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: The transcription factor signal transducer and activator of transcription 3 (STAT3) plays a central role in cell survival and function. STAT3 has been demonstrated to participate in the maintenance of bone homeostasis in osteoblasts, but its role in osteoclasts in vivo remains poorly defined. Here, we generated a conditional knockout mouse model in which Stat3 was deleted in osteoclasts using a cathepsin K-Cre (Ctsk-Cre) driver. We observed that osteoclast-specific Stat3 deficiency caused incr...
13 CitationsSource
#1Shuliang Yang (ZJU: Zhejiang University)
#1Shuliang Yang (ZJU: Zhejiang University)H-Index: 1
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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: Orthodontic treatment is more complicated when both soft and hard tissues must be considered because an impacted maxillary canine has important effects on function and esthetics. Compared with extraction of impacted maxillary canines, exposure followed by orthodontic traction can improve esthetics and better protect the patient's teeth and alveolar bone. Therefore, in order to achieve desirable tooth movement with minimal unexpected complications, a precise diagnosis is indispensable to establ...
1 CitationsSource
#1Siru ZhouH-Index: 7
#2Yiling YangH-Index: 4
Last. Lingyong JiangH-Index: 8
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OBJECTIVE: The aim of the study was to study the specific morphological features of alveolar bone and compare it to femoral bone in rats. METHODS: Twelve 3-month-old nonpregnant female Sprague-Dawley rats were used in the present study. The left maxillae and femurs of 6 rats were used for micro-computed tomography (micro-CT) scanning. The trabecular bone of the distal femur and the interradicular alveolar bone of the maxillary first molar were reconstructed and analyzed. Another 6 rats were used...
9 CitationsSource
#1Peng Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 24
#1Peng Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 26
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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: There is a growing body of evidence indicating an association between osteoporosis and vascular diseases, which are associated with reduced blood supply. Decreased vascular flow results in a hypoxic gradient in the local microenvironment, affecting local bone remodeling. Bone mesenchymal stem cells (BMSCs) have been demonstrated to be the key to bone remodeling. To elucidate the molecular mechanisms involved in vascular supply and osteoporosis, the present study investigated the effect of hypo...
10 CitationsSource
#1Xi Yang (SJTU: Shanghai Jiao Tong University)H-Index: 12
#2Yiling Yang (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Lingyong Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 8
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BACKGROUND: Osteoporosis is a world-wide health problem, which leads to decreased bone strength and increased susceptibility to fractures. Puerarin, a phytoestrogen extracted from Pueraria lobata (Willd.) Ohwi, has been identified as a promising intervention for preventing bone loss and promoting bone regeneration. However, the underlying mechanisms for its anabolic action are still not clear. In the present study, we aimed to investigate the effect of puerarin on the osteogenic differentiation ...
11 CitationsSource
#1Qinggang Dai (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Zhan Xu (CAS: Chinese Academy of Sciences)H-Index: 3
Last. Weiguo Zou (CAS: Chinese Academy of Sciences)H-Index: 27
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mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression
32 CitationsSource
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