Cristian Ortiz-Villalón
Karolinska University Hospital
GeneSurvival analysisAnaplastic lymphoma kinaseInternal medicinePathologyOncologyGene expressionImmunohistochemistryLung cancerChemotherapyCarcinomaLungBronchoscopyPD-L1AdenocarcinomaTargeted therapyPopulation basedNever smokersConfidence intervalCancer researchProportional hazards modelClinical significanceMedicineBiology
Publications 16
#1Julia Prays (Karolinska University Hospital)
#2Cristian Ortiz-Villalón (Karolinska University Hospital)H-Index: 4
Thymic epithelial tumors (TETs) are extremely rare and represent the most frequent tumors of the anterior mediastinum originating from epithelial cells in the thymus. Thymic epithelial tumors include thymomas (TM), thymic carcinomas (TC) and thymic neuroendocrine neoplasms (TNEN). Thymomas are the most predominant and are associated with autoimmune diseases. The available data suggests that the different histological subtypes have specific molecular alterations. Thymic carcinoma shows recurrent ...
#1M. Angeles Montero (University of Manchester)H-Index: 3
#2Ozan Aricak (Karolinska University Hospital)
Last. Cristian Ortiz-Villalón (KI: Karolinska Institutet)H-Index: 4
view all 14 authors...
Abstract Introduction PD1/PD-L1 pathway targeting therapies are nowadays an established treatment option for patients with NSCLC. We assessed whether PD-L1 expression in NSCLC tumor cells was associated with specific clinical features or overall survival using four different clones. Methods and results A retrospective study included formalin-fixed paraffin embedded (FFPE) surgical tumors from 482 patients. PD-L1 status was assessed with immunohistochemistry in tumor cells on tissue microarrays u...
#1Helena Liljedahl (Lund University)H-Index: 1
#2Anna Karlsson (Lund University)H-Index: 57
Last. Johan Staaf (Lund University)H-Index: 49
view all 22 authors...
Disease recurrence in surgically treated lung adenocarcinoma (AC) remains high. New approaches for risk stratification beyond tumor stage are needed. Gene expression-based AC subtypes like the TCGA terminal-respiratory unit (TRU), proximal-inflammatory (PI), and proximal-proliferative (PP) subtypes, have been associated with prognosis, but show methodological limitations for robust clinical use. We aimed to derive a platform independent single sample predictor (SSP) for molecular subtype assignm...
1 CitationsSource
#1Salomon Tendler (KI: Karolinska Institutet)H-Index: 2
#2Lena Kanter (KI: Karolinska Institutet)H-Index: 18
Last. Luigi De Petris (KI: Karolinska Institutet)H-Index: 21
view all 6 authors...
OBJECTIVES The aim was to analyse the tumor expression of Notch1, Hes1, Ascl1, and DLL3 in Small-Cell Lung Cancer (SCLC) and each such biomarker's potential association with clinical characteristics and prognosis after platinum-doublet chemotherapy (PDCT). MATERIAL AND METHODS The protein expression of the biomarkers was evaluated using immunohistochemistry. Patients were categorized according to their sensitivity to first line PDCT: with a Progression-free survival (PFS) ≥ 3 months after comple...
3 CitationsSource
#1Georgios Tsakonas (KI: Karolinska Institutet)H-Index: 5
#2Rolf Lewensohn (KI: Karolinska Institutet)H-Index: 46
Last. Simon Ekman (KI: Karolinska Institutet)H-Index: 11
view all 11 authors...
BACKGROUND: Dissemination of non-small-cell lung cancer (NSCLC) in the central nervous system is a frequent and challenging clinical problem. Systemic or local therapies rarely prolong survival and have modest activity regarding local control. Alterations in gene expression in brain metastasis versus primary tumour may increase aggressiveness and impair therapeutic efforts. METHODS: We identified 25 patients with surgically removed NSCLC brain metastases in two different patient cohorts. For 13 ...
8 CitationsSource
#2Magnus P. JonssonH-Index: 31
Last. Maria PlanckH-Index: 17
view all 21 authors...
#1Anna Karlsson (Lund University)H-Index: 57
#2Helena Cirenajwis (Lund University)H-Index: 12
Last. Johan Staaf (Lund University)H-Index: 49
view all 20 authors...
Accurate histological classification and identification of fusion genes represent two cornerstones of clinical diagnostics in non-small cell lung cancer (NSCLC). Here, we present a NanoString gene expression platform and a novel platform-independent, single sample predictor (SSP) of NSCLC histology for combined, simultaneous, histological classification and fusion gene detection in minimal formalin fixed paraffin embedded (FFPE) tissue. The SSP was developed in 68 NSCLC tumors of adenocarcinoma ...
11 CitationsSource
#1M. Angeles Montero (University of Manchester)H-Index: 3
#2Javier de Gracia (Autonomous University of Barcelona)H-Index: 25
Last. Cristian Ortiz-Villalón (Karolinska University Hospital)H-Index: 4
view all 7 authors...
AIMS: Lung transplant monitoring is usually performed with forceps transbronchial biopsies. These types of biopsy show limited reliability and a high degree of variability, owing to insufficient material and compression artefact, which lead to misinterpretation and, eventually, inappropriate treatment of the transplanted patients. The following study was undertaken to assess the diagnostic yield, histological quality and safety of cryobiopsy (CB) in comparison with conventional forceps biopsy (F...
8 CitationsSource
#1Annette Salomonsson (Lund University)H-Index: 3
#2Annika Patthey (Umeå University)H-Index: 2
Last. Maria Planck (Lund University)H-Index: 17
view all 20 authors...
Background: Smoking is by far the most important cause of lung cancer. However, lung cancer among never-smokers is common and increasing [1]. A smoking-independent subgroup of lung adenocarcinoma w ...