Phung Thanh Huong
Hanoi University
CytotoxicityAcetylationCancerDocking (molecular)EndocrinologyChemistryTumor microenvironmentKnemaCarcinoembryonic antigenHematopoietic stem cell transplantationMetastasisGraft-versus-host diseaseAMPKAngiogenesisTransplantationCancer researchCirculating tumor cellMedicinePlateletCancer cell
Publications 7
#1Nguyen Thi Tu Oanh (VAST: Vietnam Academy of Science and Technology)H-Index: 2
#2Pham Tran Thu Ha (Hanoi University)
Last. Le Nguyen Thanh (VAST: Vietnam Academy of Science and Technology)H-Index: 3
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1 CitationsSource
#1Hung D. Nguyen (UCF: University of Central Florida)H-Index: 1
#2Phung Thanh Huong (Hanoi University)H-Index: 3
Last. Hung N. Luu (University of Pittsburgh)H-Index: 11
view all 9 authors...
Allogeneic bone marrow transplantation (BMT) is an effective therapy for hematological malignancies due to the graft-versus-leukemia (GVL) effect to eradicate tumors. However, its application is limited by the development of graft-versus-host disease (GVHD), a major complication of BMT. GVHD is evoked when T-cells in the donor grafts recognizealloantigen expressed by recipient cells and mount unwanted immunological attacks against recipient healthy tissues. Thus, traditional therapies are design...
#1Phung Thanh Huong (Hanoi University)H-Index: 3
#2Sanjeev Gurshaney (UCF: University of Central Florida)H-Index: 1
Last. Hung N. Luu (University of Pittsburgh)H-Index: 11
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With over 1 million incidence cases and more than 780,000 deaths in 2018, gastric cancer (GC) was ranked as the 5th most common cancer and the 3rd leading cause of cancer deaths worldwide. Though several biomarkers, including carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), and cancer antigen 72-4 (CA72-4), have been identified, their diagnostic accuracies were modest. Circulating tumor cells (CTCs), cells derived from tumors and present in body fluids, have recently emerged as prom...
7 CitationsSource
#1Phung Thanh Huong (Hanoi University)H-Index: 3
#2Lap Thi Nguyen (Hanoi University)H-Index: 2
Last. Duc-Hiep Bach (SNU: Seoul National University)H-Index: 13
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Besides the critical functions in hemostasis, thrombosis and the wounding process, platelets have been increasingly identified as active players in various processes in tumorigenesis, including angiogenesis and metastasis. Once activated, platelets can release bioactive contents such as lipids, microRNAs, and growth factors into the bloodstream, subsequently enhancing the platelet–cancer interaction and stimulating cancer metastasis and angiogenesis. The mechanisms of treatment failure of chemot...
41 CitationsSource
#1Tran Thi Lan Huong (Hanoi University)H-Index: 5
#2Do Thi Mai Dung (Hanoi University)H-Index: 5
Last. Nguyen-Hai Nam (Hanoi University)H-Index: 24
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Abstract In a continuation of a research program to discover novel small molecules targeting histone deacetylases, a series of 2′-oxospiro[1,3]dioxolane/dithiolane-2,3′-indoline-based hydroxamic acids have been designed and synthesized. These 2-oxoindoline-based hydroxamic acids displayed potent cytotoxicity against three human cancer cell lines, including SW620 (colon cancer), PC-3 (prostate cancer) and AsPC-1 (pancreatic cancer), with IC 50 values as low as 0.05–0.07 μM, 74-fold lower than tha...
9 CitationsSource
#1Do Ngoc Lien (VNU: Vietnam National University, Hanoi)H-Index: 1
#2Nguyen ThiH-Index: 1
Last. Phung Thanh Huong (VNU: Vietnam National University, Hanoi)H-Index: 3
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The aim of this study was to assess the effects of Pomelo (Citrus grandis (L.) Osbeck) peel extracts (CGE) on activity of lipid-carbohy drate metabolic enzymes such as Carnitine pamitoyl-transferase (CPT), lipase, hexokinase, glucose 6-phosphatase and blood lipid glucose parameters in experimental obese and diabetic mice. The results showed that, in the experimental obese mice treated daily, orally with CGE at dose of 1200 mg/body weight for three weeks, activity of hepatic CPT have been raised ...
2 Citations