Yunpu Xiong
Guangzhou University
Regenerative medicinePhosphorylationAdipogenesisCXCR4Molecular biologyAndrologyRegeneration (biology)Adipose tissueChemistryApoptosisMesenchymal stem cellIn vivoSuperoxide dismutasePropidium iodideOxidative stressRUNX2Western blotROCK2Bone marrowFemoral fractureStem cellPopulationTransplantationFemur fractureBone regenerationReactive oxygen speciesCancer researchViability assayMedicineMyosin light-chain kinaseBone healingBiologyAnnexinCell biology
Publications 4
#1Jun-Lang Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
#2Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 10
Last. Wang Bin (Guangzhou University of Chinese Medicine)H-Index: 4
view all 14 authors...
Abstract Background Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only a small number of implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration of MSCs in injured tissue. Methods The migration and osteogenesis of MSCs were assessed by transwell assay and Alizarin Red S staining. Levels of gene and protein expressio...
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 10
#2Wang-Yang Li (Hunan University)H-Index: 2
Last. Wang Bin (GU: Guangzhou University)H-Index: 4
view all 14 authors...
ABSTRACT MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil (CTVO) was found to facilitate MSC migration. Further explorat...
#1Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 24
#2Yamei Liu (GU: Guangzhou University)H-Index: 10
Last. Gang LiH-Index: 81
view all 10 authors...
Background Mesenchymal stem cells (MSCs) possess intrinsic regeneration capacity as part of the repair process in response to injury, such as fracture or other tissue injury. Bone marrow and adipose tissue are the major sources of MSCs. However, which cell type is more effective and suitable for cell therapy remains to be answered. The intrinsic molecular mechanism supporting the assertion has also been lacking.
#1Wangyang Li (GU: Guangzhou University)H-Index: 1
#2Yamei Liu (GU: Guangzhou University)H-Index: 10
Last. Yunpu Xiong (GU: Guangzhou University)H-Index: 2
view all 8 authors...
: Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to be used for the treatment of delayed union, nonunion or persistent bone defects in MSC-based cell therapy. However, implantation of BMSCs into the fracture site is confronted with apoptosis on account of harsh conditions and oxidative stress. In the present study, the anti-apoptotic effects of berberine (BBR) on BMSCs subjected to hydrogen peroxide (H2O2) are investigated, and the potential underlying mechanisms are explo...
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