Yiwen Luo
Guangzhou University of Chinese Medicine
Regenerative medicinePhosphorylationCXCR4microRNACellular differentiationCellMolecular biologyAlkaline phosphataseReporter geneTranscriptomeAndrologyCalcitriol receptorGene expression profilingChemistryApoptosisProtein kinase CMesenchymal stem cellIn vitroImmunologyIn vivoSmall interfering RNASuperoxide dismutasePropidium iodideOxidative stressRUNX2Western blotOsteoporosisOsteoblastDiseaseROCK2Homing (hematopoietic)Psoralea corylifoliaBone marrowFemoral fractureWNT5AWound healingCartilageMTT assayOsteopontinOncogenePsoralenStem cellPopulationGastrointestinal MicrobiomeTransplantationAging societyFemur fractureClose relationshipHealth problemsChondrogenesisReactive oxygen speciesCa2+/calmodulin-dependent protein kinaseCancer researchViability assayGut floraTransfectionSignal transductionMedicineMyosin light-chain kinaseBone healingTranscription factorBiologyHedgehog signaling pathwayAnnexinImmune systemCell biology
11Publications
5H-index
53Citations
Publications 10
Newest
#1Jun-Lang Zhu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Wang Bin (Guangzhou University of Chinese Medicine)H-Index: 4
view all 14 authors...
Abstract Background Mesenchymal Stem Cells (MSCs) therapy has become a new coming focus of clinical research in regenerative medicine. However, only a small number of implanted MSCs could successfully reach the injured areas. The previous studies have shown that fracture healing time is inversely proportional to concentration of MSCs in injured tissue. Methods The migration and osteogenesis of MSCs were assessed by transwell assay and Alizarin Red S staining. Levels of gene and protein expressio...
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#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Liangliang Xu (Guangzhou University of Chinese Medicine)H-Index: 22
Last. Gang Li (CUHK: The Chinese University of Hong Kong)H-Index: 84
view all 12 authors...
Abstract Mesenchymal stem cells (MSCs) can be easily expanded without losing the ability of multilineage differentiation, including oesteogenic, chondrogenic and adipogenic differentiation. These characters make MSCs a promising cell resource for cartilage defect repair. MSCs could be recruited by inflammatory stimulation, then home to the injury tissues. However, its capacity of homing is extremely limited. Thus, it has become extremely necessary to develop an agent or a method, which can be us...
2 CitationsSource
#1Yongquan Huang (Guangzhou University of Chinese Medicine)H-Index: 6
#2Qiuke Hou (Guangzhou University of Chinese Medicine)H-Index: 7
Last. Tao Jiang (Guangzhou University of Chinese Medicine)H-Index: 2
view all 6 authors...
: It has been previously reported that psoralen, one of the active ingredients in Psoralea corylifolia, could induce osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), suggesting its potential to treat osteoporosis. Additionally, runt‑related transcription factor 2 (Runx2) is a transcription factor that plays vital roles in BMSC osteogenic differentiation. However, whether and how microRNAs (miRNAs/miRs) modulate osteogenic differentiation induced by psoralen have not yet ...
9 CitationsSource
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Wang-Yang Li (Hunan University)H-Index: 1
Last. Wang Bin (GU: Guangzhou University)H-Index: 4
view all 14 authors...
ABSTRACT MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil (CTVO) was found to facilitate MSC migration. Further explorat...
2 CitationsSource
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 3
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Yiwen Luo (Guangzhou University of Chinese Medicine)H-Index: 3
view all 13 authors...
: Bone fractures are very common, and above 5% of the fractures are impaired, leading to nonunions and severe disablilities. The traditional Chinese medicine Bushen Huoxue decoction (BHD) has been used to treat fracture in China. Our previous report has found that BHD promotes migration of rat mesenchymal stem cells (rMSCs) by activating Wnt5a signaling pathway. However, whether and how miRNAs are involved in modulating rMSCs migration induced by BHD has not been explored. In the present study, ...
2 CitationsSource
#1Qiuke Hou (Guangzhou University of Chinese Medicine)H-Index: 7
#2Yongquan Huang (Guangzhou University of Chinese Medicine)H-Index: 6
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 9 authors...
Our previous study showed that (+)-cholesten-3-one (CN) has the potential to induce the osteoblastic differentiation of mesenchymal stem cells (MSCs). However, the roles of CN in targeting miRNA-mRNA-lncRNA interactions to regulate osteoblast differentiation remain poorly understood. A total of 77 miRNAs (36 upregulated and 41 downregulated) and 295 lncRNAs (281 upregulated and 14 downregulated) were significantly differentially expressed during CN-induced MSC osteogenic differentiation. Bioinfo...
11 CitationsSource
#1Wei Shen (GU: Guangzhou University)H-Index: 2
#2Hui Luo (GU: Guangzhou University)H-Index: 1
Last. Yiwen Luo (GU: Guangzhou University)H-Index: 5
view all 10 authors...
Background Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mesenchymal stem cell (BMSC) migration through the Wnt5a signalling pathway.
6 CitationsSource
#1Qiuke Hou (GU: Guangzhou University)H-Index: 3
#2Yong-Quan Huang (GU: Guangzhou University)H-Index: 2
Last. Dong-Feng Chen (GU: Guangzhou University)H-Index: 6
view all 9 authors...
Our previous reports indicated that (+)-cholesten-3-one induces osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) by activating vitamin D receptor (VDR). However, whether and how miRNAs modulate osteogenic differentiation induced by (+)-cholesten-3-one have not been explored. In this study, miRNA array profiling and further validation by quantitative real-time PCR revealed that miR-351 was downregulated during (+)-cholesten-3-one-induced osteogenic differentiation of MSCs. ...
5 Citations
#1Wangyang Li (GU: Guangzhou University)H-Index: 1
#2Yamei Liu (GU: Guangzhou University)H-Index: 9
Last. Yunpu Xiong (GU: Guangzhou University)H-Index: 2
view all 8 authors...
: Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to be used for the treatment of delayed union, nonunion or persistent bone defects in MSC-based cell therapy. However, implantation of BMSCs into the fracture site is confronted with apoptosis on account of harsh conditions and oxidative stress. In the present study, the anti-apoptotic effects of berberine (BBR) on BMSCs subjected to hydrogen peroxide (H2O2) are investigated, and the potential underlying mechanisms are explo...
16 CitationsSource
#1Yong-Quan HuangH-Index: 2
#2Tao JiangH-Index: 2
Last. Qiuke HouH-Index: 7
view all 5 authors...
The rapidly evolving aging society in China is associated with increased incidences of osteoporosis and fractures, which have become common health problems that threaten the quality of life of the elderly. Gut microbiota colonizing in the human intestinal tract form a mutual symbiotic relationship with the host and play an important role in the metabolism and immune regulation of the host. In recent years increasing studies have demonstrated that gut microbiota not only affect the digestive syst...
3 CitationsSource