Deepti Singh
Massachusetts Eye and Ear Infirmary
Self-healing hydrogelsBiophysicsNanotechnologyChemistryExtracellular matrixMaterials scienceIn vitroRetinaBiocompatibilityRetinal pigment epitheliumGelatinDrug deliveryRetinalStem cellChemical engineeringTissue engineeringMedicineBiologyScaffoldCell biology
68Publications
14H-index
617Citations
Publications 58
Newest
#1Daniel J. ThomasH-Index: 9
#1Daniel Thomas (Harvard University)H-Index: 3
Last. Deepti Singh (Harvard University)H-Index: 14
view all 2 authors...
Abstract In this research study we report the fabrication of a cross-linkable calcium phosphate biocomposite to engineer a replica mandible bone structure for surgical implantation. This novel material has been used to form an orthopaedic scaffold implant, which has been 3D printed with trabecular features, 280 μm channels with tuneable and controllable surface properties, architecture and external pore geometry. The biomaterial properties and the developed extrusion processes were optimized to ...
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#1Daniel Thomas (Harvard University)H-Index: 3
#2Deepti Singh (Harvard University)H-Index: 14
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#1Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Deepti SinghH-Index: 14
Last. Michael J. YoungH-Index: 43
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#1Deepti Singh (Yale University)H-Index: 14
#2Daniel ThomasH-Index: 3
Last. Anjan Motamarry (Harvard University)H-Index: 6
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#1Deepti SinghH-Index: 14
#2Daniel ThomasH-Index: 3
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#1Deepti Singh (Harvard University)H-Index: 14
#2Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Michael J. Young (Harvard University)H-Index: 43
view all 5 authors...
The optic pathway glioma (OPG) is a slow-growing brain tumor that arises along the optic nerve or its downstream connections and causing vision to gradually worsen with time. This tumor forms in ch...
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#1Deepti Singh (Yale University)H-Index: 14
#2Xiaoyu Chen (Yale University)H-Index: 1
Last. Lawrence J. Rizzolo (Yale University)H-Index: 34
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1 CitationsSource
1 Citations
#1Pierre C. Dromel (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Deepti Singh (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 14
Last. Michael J. Young (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 43
view all 6 authors...
Abstract Many progenitor and stem cell-based therapies in pre-clinical development and in clinical trial have failed to achieve desired outcomes, in part, due to: low cell viability; dispersion of cells from the injection site; and/or failure of the cells to differentiate and engraft into host tissue. These problems may be exacerbated by the elevated shear stress applied to the cells as they pass through a small-bore needle. Our supposition is that these issues can be mitigated by replacing the ...
1 CitationsSource
#1Daniel Thomas (Harvard University)H-Index: 3
#2Deepti Singh (Harvard University)H-Index: 14
As 3D Printing methods have improved and newer advanced materials have been introduced then the ability to create a range of 3D printed prosthetic devices has developed. 3D Printing has allowed us to produce prosthetic devices that are customised to the needs of a patient. As a result, 3D printing offers a way towards the manufacture of ultraprecise patient-specific prosthetic devices to be generated at the point of care within the hospital. Because prosthetic devices can be cost effectively mad...
1 CitationsSource