Jun Luo
China Pharmaceutical University
Chirality (chemistry)Circular dichroismOrganic chemistryChemistryTwo-dimensional nuclear magnetic resonance spectroscopyAbsolute configurationSesquiterpeneMoietyVelutinaAphanamixisLimonoidAnti-inflammatoryRing (chemistry)MeliaceaePhragmalinChukrasia tabularisTerpeneBiochemistryTraditional medicineStereochemistryBiology
198Publications
22H-index
1,808Citations
Publications 180
Newest
#1Li LiH-Index: 2
#2Shan LiH-Index: 1
Last. Jun LuoH-Index: 22
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#1Yunpeng Sun (CPU: China Pharmaceutical University)
#2Qiurong Li (CPU: China Pharmaceutical University)H-Index: 1
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Munrolins A-Q (1-17), 17 new ring C-seco limonoids with diverse oxidative patterns of C-12, together with nine known analogues (18-26), were isolated from the CH2Cl2 extract of Munronia unifoliolata. The planar structures were elucidated by a combination of 1D and 2D NMR and HR-MS analyses, while the absolute configurations were confirmed by ECD calculations and single-crystal X-ray diffraction. Munrolins A (1) and B (2) were first identified as ring C-seco limonoids with a 12,13-ether bridge mo...
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#1Yujin Sun (CPU: China Pharmaceutical University)
#2Yong Yin (CPU: China Pharmaceutical University)H-Index: 6
Last. Jun Luo (CPU: China Pharmaceutical University)H-Index: 22
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Aglatestine A (1), an unprecedented 3/6/6 tricarbocyclic limonoid framework along with four biogenic A/D-seco limonoid analogues with rare β-substituents at C-6 (2-5), was discovered from the fruits of Aglaia edulis. The structures of 1-5 along with their absolute configurations were clarified using methods of HRMS(ESI), NMR, electronic circular dichroism, X-ray diffraction crystallography, and quantum chemical calculations. The plausible biogenetic speculation suggested that an electrophilic cy...
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#1Yunpeng Sun (CPU: China Pharmaceutical University)
#2Letian Cui (CPU: China Pharmaceutical University)H-Index: 1
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract null null Mufolinin A (1), a ring A-seco rearranged limonoid with an unprecedented ethyl at C-10 and novel 6/6/6/5 fused-ring skeleton, together with three new potential precursors (ring A-seco limonoids, 2–4) were isolated from Munronia unifoliolata. Their structures and absolute configurations were confirmed by nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), X-ray crystallography, electronic circular dichroism (ECD) calculations a...
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#1Yun-Ge Bu (CPU: China Pharmaceutical University)H-Index: 1
#2Wen-Yan Zhang (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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A new andirobin-type limonoid with modified furan ring, khaysenelide K (1), together with a known analogue (2), was isolated from the stem barks of Khaya senegalensis. The structure and absolute co...
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#1Zhirong Cui (CPU: China Pharmaceutical University)H-Index: 3
#2Yi Li (Nanjing Normal University)H-Index: 4
Last. Jun Luo (CPU: China Pharmaceutical University)H-Index: 22
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INTRODUCTION Melia toosendan Sieb. et Zucc. has been used as a Chinese folk medicine for roundworm treatment since ancient times. Many diverse limonoids have been isolated from Meliaceae plants, but it remains difficult to isolate and identify other limonoids because of their small natural concentrations. OBJECTIVE This study was performed to overcome the difficulties associated with fast and accurate identification of limonoids and establish a reliable and sensitive method for the analysis of m...
1 CitationsSource
#1Wei-Xian Li (CPU: China Pharmaceutical University)
#2Wen-Jun Xu (CPU: China Pharmaceutical University)H-Index: 7
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Two new type B polycyclic polyprenylated acylphloroglucinols (PPAPs) (1 and 2) and a known biogenetic precursor hyperbeanol Q (3) were isolated from the root extract of Hypericum beanii, a medicinal plant widespread in southwest China. Their chemical structures were elucidated by 1D/2D NMR and HRESIMS data analysis, and absolute configurations were determined through detailed electric circular dichroism (ECD) analysis including ECD exciton chirality, Mo2(OAc)4-induced ECD, and ECD comparison. Of...
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#1Fa-Liang An (ECUST: East China University of Science and Technology)H-Index: 2
#2Dong-Mei Sun (CPU: China Pharmaceutical University)H-Index: 3
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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#1Qi-Ji LiH-Index: 1
#2Pengfei TangH-Index: 3
Last. Ling-Yi KongH-Index: 58
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Inspired by a geranyl-originated undecanoate acid ethyl ester (biosynthetic fragment, 9), elodeoidins A–H (1–8), representing four unprecedented rearranged acylphloroglucinol meroterpenoids, were discovered from the herb of Hypericum elodeoides. Their structures were elucidated by HRESIMS, NMR, Mosher, ECD, quantum chemical calculations, and biosynthetic pathways. Structurally, the six-membered acylphloroglucinol core rearranged to a five-membered β-diketone unit possessing an exocyclic carbonyl...
2 CitationsSource
#1Panpan Zhang (CPU: China Pharmaceutical University)H-Index: 3
#2Shang Xue (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract Aphamines A–C (1–3), three pairs of acyclic diterpene dimer enantiomers with an unprecedent ploymerization pattern, were discovered from Aphanamixis polystachya by NMR-guided isolation and chiral resolution. The elucidation of their novel carbon skeletons was achieved based on spectroscopic analysis, exciton chirality, and calculated electronic circular dichroism (ECD). Plausible Claisen rearrangement, 5-exo-trig cyclization, and reduction reactions may play important roles in the polym...
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