Sandro Sieber
University of Basel
Colloidal goldDispersityMicrometreBiophysicsTargeted drug deliveryBiomedical engineeringArtificial cellCellNanomedicineNanoparticleNanotechnologyEnzymeNanocarriersLiposomeChemistryMaterials scienceIn vitroIn vivoPorous siliconZebrafishBiodistributionCell membraneDrug deliveryDrugSurface chargeProtein CoronaNonlinear opticalTumor imagingZebrafish embryoCancer treatmentHigh resolutionTumor cellsComputer sciencePolymersomePEG ratioBiochemistryResolution (electron density)Cell cultureMicrofluidicsOptical imagingCell biology
22Publications
9H-index
431Citations
Publications 22
Newest
#1Ali Y. Sonay (ETH Zurich)H-Index: 6
#2Konstantinos Kalyviotis (Imperial College London)
Last. Periklis Pantazis (ETH Zurich)H-Index: 19
view all 15 authors...
Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they can be imaged with little background signal and unmatched long-term photostability. As their chemical composition often includes transition metals, the use of inorganic SHG nanoprobes can raise long-term health concerns. Ideally, contrast agen...
Source
1 CitationsSource
#1Emre Cörek (University of Basel)H-Index: 2
#2Griffin Rodgers (University of Basel)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
view all 14 authors...
Metal-based nanoparticles are clinically used for diagnostic and therapeutic applications. After parenteral administration, they will distribute throughout different organs. Quantification of their distribution within tissues in the 3D space, however, remains a challenge owing to the small particle diameter. In this study, synchrotron radiation-based hard X-ray tomography (SRμCT) in absorption and phase contrast modes is evaluated for the localization of superparamagnetic iron oxide nanoparticle...
1 CitationsSource
#1Emre Cörek (University of Basel)H-Index: 2
#2Griffin Rodgers (University of Basel)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
view all 14 authors...
Source
#1Flavia FontanaH-Index: 18
Last. Hélder A. Santos (UH: University of Helsinki)H-Index: 69
view all 15 authors...
Biohybrid nanosystems represent the cutting-edge research in biofunctionalization of micro- and nano-systems. Their physicochemical properties bring along advantages in the circulation time, camouflaging from the phagocytes, and novel antigens. This is partially a result of the qualitative differences in the protein corona, and the preferential targeting and uptake in homologous cells. However, the effect of the cell membrane on the cellular endocytosis mechanisms and time has not been fully eva...
1 CitationsSource
#1Juan Liu (University of Basel)H-Index: 5
#2Ioana Craciun (University of Basel)H-Index: 8
Last. Cornelia G. Palivan (University of Basel)H-Index: 36
view all 10 authors...
DNA has been widely used as a key tether to promote self-organization of super-assemblies with emergent properties. However, control of this process is still challenging for compartment assemblies, and to date the resulting assemblies have unstable membranes precluding in vitro and in vivo testing. Here we present our approach to overcome these limitations, by manipulating molecular factors such as compartment membrane composition and DNA surface density, thereby controlling the size and stabili...
2 CitationsSource
#1Daniel Ehrsam (University of Basel)H-Index: 2
#2Sandro Sieber (University of Basel)H-Index: 9
Last. Henriette E. Meyer zu Schwabedissen (University of Basel)H-Index: 31
view all 7 authors...
The concept of triggered drug release offers a possibility to overcome the toxic side effects of chemotherapeutics in cancer treatment by reducing systemic exposure to the active drug. In the present work, the concept forsees the use of the extracellular enzyme MMP9 as an enzymatic trigger for drug release in the proximity of tumor cells. Methods: A paclitaxel-hemisuccinate-peptide conjugate as a building block for self-assembling nanoparticles was synthesized using standard conjugation approach...
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#1Tomaž Einfalt (University of Basel)H-Index: 2
#2Martina Garni (University of Basel)H-Index: 6
Last. Cornelia G. Palivan (University of Basel)H-Index: 36
view all 8 authors...
Despite huge need in the medical domain and significant development efforts, artificial cells to date have limited composition and functionality. Although some artificial cells have proven successful for producing therapeutics or performing in vitro specific reactions, they have not been investigated in vivo to determine whether they preserve their architecture and functionality while avoiding toxicity. Here, these limitations are overcome and customizable cell mimic is achieved-molecular factor...
9 CitationsSource
#1Stefan Bleher (University of Freiburg)H-Index: 2
#2Jonas Buck (University of Basel)H-Index: 3
Last. Regine Süss (University of Freiburg)H-Index: 15
view all 9 authors...
Circulation lifetime is a crucial parameter for a successful therapy with nanoparticles. Reduction and alteration of opsonization profiles by surface modification of nanoparticles is the main strategy to achieve this objective. In clinical settings, PEGylation is the most relevant strategy to enhance blood circulation, yet it has drawbacks, including hypersensitivity reactions in some patients treated with PEGylated nanoparticles, which fuel the search for alternative strategies. In this work, l...
14 CitationsSource
#1Dominik Witzigmann (University of Basel)H-Index: 16
#2Philipp Uhl (University Hospital Heidelberg)H-Index: 7
Last. Jörg Huwyler (University of Basel)H-Index: 49
view all 16 authors...
: Active targeting and specific drug delivery to parenchymal liver cells is a promising strategy to treat various liver disorders. Here, we modified synthetic lipid-based nanoparticles with targeting peptides derived from the hepatitis B virus large envelope protein (HBVpreS) to specifically target the sodium-taurocholate cotransporting polypeptide (NTCP; SLC10A1) on the sinusoidal membrane of hepatocytes. Physicochemical properties of targeted nanoparticles were optimized and NTCP-specific, lig...
11 CitationsSource