Jian Huang
Harbin Medical University
TriterpenoidCytotoxicityCircular dichroismInfrared spectroscopyOrganic chemistryKinaseChemistryApoptosisGlycosideTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroAutophagyHeLaIC50EuphorbiaProgrammed cell deathChromatographyCancer researchNitric oxideBiochemistryTraditional medicineSignal transductionStereochemistryMedicineBiologyCell biologyCancer cellPharmacology
118Publications
20H-index
1,204Citations
Publications 108
Newest
#1Dahong Yao (HMU: Harbin Medical University)H-Index: 3
#2Jin Jiang (HMU: Harbin Medical University)H-Index: 1
Last. Jin-Hui Wang (HMU: Harbin Medical University)H-Index: 18
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Abstract null null The excessive activation of histone deacetylase (HDAC) and mammalian target of rapamycin (mTOR) signaling promotes tumor growth and progression. We proposed that dual targeting mTOR and HDAC inhibitors is a promising strategy for triple negative breast cancer (TNBC) treatment. In this study, a series of dual mTOR/HDAC6 inhibitors were designed and synthesized by structure-based strategy. 10g was documented to be a potent dual mTOR/HDAC6 inhibitor with IC50 value of 133.7 nM ag...
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#1Yaping GuoH-Index: 1
#2Hong YangH-Index: 2
Last. Jin-Hui WangH-Index: 18
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Crataegi folium have been used as medicinal and food materials worldwide due to its pharmacological activities. Although the leaves of Crataegus songorica (CS), Crataegus altaica (CA) and Crataegus kansuensis (CK) have rich resources in Xinjiang, China, they can not provide insights into edible and medicinal aspects. Few reports are available on the qualitative and quantitative analysis of flavonoids compounds of their leaves. Therefore, it is necessary to develop efficient methods to determine ...
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#1Ma Qingdong (Shihezi University)
#2Ke Zhang (Shihezi University)H-Index: 9
Last. Jin-Hui WangH-Index: 18
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Abstract A novel seco-pregnane steroid bearing an oxygen-bridged structure and two new sesquiterpene lactones—namely, sausinone (1),14-oxidized mokko lactone (2), and (1R, 5R, 6R, 7R, 8S, 11S)-11,13-dihydrodehydrocostuslactone-8-O-6′-2″ (Z)-butenoyl-β-D-glucopy-ranoside (3)—along with 12 known compounds (4–15) were isolated from Saussurea involucrata. Notably, compounds 12–15 were isolated from this plant for the first time. Their structures were mainly established by one- and two-dimensional nu...
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#2Weina HanH-Index: 2
Last. Baofeng YangH-Index: 69
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Cardiac fibrosis is a common pathological manifestation accompanied with various heart diseases, and anti-fibrotic therapy is an effective strategy to prevent diverse pathological processes of cardiovascular system. We currently report the rational design, synthesis and pharmacological evaluation of a novel anthraquinone compound (1,8-dihydroxy-6-methyl-9,10-anthraquinone-3-oxy ethyl succinate) named Kanglexin (KLX), as a potent cardioprotective agent with anti-fibrosis activity. Our results dem...
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#1Huanyue Cui (Shihezi University)
#2Xue-ying Liu (Shihezi University)H-Index: 2
Last. Jin-Hui Wang (Shihezi University)H-Index: 18
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The root cause behind the development of chronic obstructive pulmonary disease (COPD) is cigarette smoke that induces the inflammation of the lung tissue and alveolar destruction. Long-term cigarette smoking can lead to deterioration in lung parenchymal function and cause structural changes in the lung, further resulting in pulmonary fibrosis. Rhodiola rosea L., a traditional medicinal perennial herb, is well known for its numerous pharmacological benefits, including anti-inflammation, antioxida...
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#1Hong Yang (HMU: Harbin Medical University)H-Index: 2
#2Chunli Gan (HMU: Harbin Medical University)
Last. Jin-Hui Wang (HMU: Harbin Medical University)H-Index: 18
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Phytochemical investigation on the ethanol extract of green walnut husks (Juglans mandshurica Maxim.) led to the isolation of two previously unknown compounds, including a macrolide compound (13S)-8-oxo-(9E, 11E)-8-oxo-octadeca-9,11-dien-13-olide (1) and a diarylheptanoid compound 1-(3'-methoxy-4'-hydroxyphenyl)-7-(3″,4″-dimethoxyphenyl)heptan-3-one (2), together with 19 known compounds. The structures of these 21 compounds were elucidated by extensive analyses of NMR and HR-MS data, and the bas...
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#1Yixiu Zhao (HMU: Harbin Medical University)H-Index: 2
#2Xinhui Wang (HMU: Harbin Medical University)H-Index: 2
Last. Baofeng Yang (HMU: Harbin Medical University)H-Index: 69
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Abstract Diabetic foot is one of the main causes of non-traumatic amputation. However, there is still lack of effective drugs to treat diabetic foot in clinical practice. Kanglexin (KLX) is a new anthraquinone compound with cardiovascular protective effects. Here we report that KLX accelerates diabetic wound healing by promoting angiogenesis via FGFR1/ERK signaling. Firstly, KM mice were injected (ip) with streptozocin to establish type 1 diabetic model. The full thickness wound with the diamete...
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#2Xiaobo Pang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last. Jin-Hui Wang (SPU: Shenyang Pharmaceutical University)H-Index: 18
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OBJECTIVE To identify, rapidly and accurately, the chemical composition of the traditional Uighur formulation Baixuan Xiatare (BXXTR-FU). METHODS We investigated if application of three-stage infrared (IR) spectroscopy enabled identification of the main chemical constituents (and their origins) in BXXTR-FU. RESULTS The characteristic peaks of herbal material(s) and BXXTR-FU were assigned. In Fourier transform-IR (FT-IR) spectroscopy of BXXTR-FU, peaks at 1616 and 1605 cm-1 of BXXTR-FU were consi...
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#1Qingdong Ma (XMU: Xinjiang Medical University)H-Index: 1
#2Xiaoxiang ChenH-Index: 1
Last. Jin-Hui Wang (XMU: Xinjiang Medical University)H-Index: 18
view all 9 authors...
The quality control of Saussurea involucrata has been greatly improved by macroscopic and microscopic identification and chemical profiling described in Chinese Pharmacopoeia since 2005. However, these methods have their own limitations, e.g., their dependence on personal experience and expertise, and it is a huge challenge to identify closely related species that share similar or identical morphological characteristics and chemical profiles. A novel and generally accepted identification strateg...
1 CitationsSource
#1Dahong Yao (HMU: Harbin Medical University)H-Index: 3
#2A. Ruhan (HMU: Harbin Medical University)
Last. Weina Han (HMU: Harbin Medical University)H-Index: 2
view all 6 authors...
Abstract P21-activated kinase 1 (PAK1) plays a vital role in the proliferation, survival and migration of cancer cells, which has emerged as a promising drug target for cancer therapy. In this study, a series of 2-indolinone derivatives were designed and synthesized through a structure-based strategy. A potent PAK1 inhibitor (ZMF-005) was discovered, which presented an IC50 value of 0.22 μM against PAK1 with potent antiproliferative activity. Furthermore, we predicted the binding mode of ZMF-005...
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