Mara Artibani
Medical Research Council
GeneEnhancerEpigenomeCancerInternal medicinePhenotypeCas9PathologyOncologyGenome engineeringCellSerous fluidGene expressionMolecular biologyTranscriptomeRegulation of gene expressionMüllerian mimicrySingle cell sequencingImmunohistochemistryFallopian tubeChemotherapyOviductOvaryDiseaseImmunosuppressionOvarian cancerDuct (anatomy)Specific mutationCancer researchBreast cancerGeneticsGenetic heterogeneityClone (cell biology)Computational biologyMedicineCell cultureTranscription factorBiologyCell biologyCancer cellCRISPR
21Publications
7H-index
209Citations
Publications 20
Newest
#1Mara ArtibaniH-Index: 7
#2Kenta Masuda (University of Oxford)H-Index: 22
Last. Ahmed Ashour AhmedH-Index: 28
view all 31 authors...
Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characterized ...
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#1Laura Santana Gonzalez (University of Oxford)H-Index: 3
#2Mara Artibani (University of Oxford)H-Index: 7
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 0 authors...
Mullerian duct anomalies (MDAs) are developmental disorders of the Mullerian duct, the embryonic anlage of most of the female reproductive tract. The prevalence of MDAs is 6.7% in the general female population and 16.7% in women who exhibit recurrent miscarriages. Individuals affected by these anomalies suffer from high rates of infertility, first-trimester pregnancy losses, premature labour, placental retention, foetal growth retardation and foetal malpresentations. The aetiology of MDAs is com...
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#1Matteo Morotti (University of Oxford)H-Index: 19
#1Ahmed Ashour AhmedH-Index: 28
Last. D C Wedge
view all 21 authors...
Cancer is a leading cause of death worldwide and, despite new targeted therapies and immunotherapies, many patients with advanced-stage- or high-risk cancers still die, owing to metastatic disease. Adoptive T-cell therapy, involving the autologous or allogeneic transplant of tumour-infiltrating lymphocytes or genetically modified T cells expressing novel T-cell receptors or chimeric antigen receptors, has shown promise in the treatment of cancer patients, leading to durable responses and, in som...
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#1Laura Santana Gonzalez (University of Oxford)H-Index: 3
#2Ioanna A. Rota (University of Oxford)H-Index: 3
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 10 authors...
The conduits of life; the animal oviducts and human fallopian tubes are of paramount importance for reproduction in amniotes. They connect the ovary with the uterus and are essential for fertility as they provide the appropriate environment for gamete maintenance, fertilisation and preimplantation embryonic development. However, some of the most serious pathologies, such as ectopic pregnancy, malignancy and severe infections, occur in the oviducts. They can have drastic effects on fertility, and...
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#1Zhiyuan Hu (University of Oxford)H-Index: 4
#2Paula Cunnea (Imperial College London)H-Index: 7
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 21 authors...
Purpose: Using RNA sequencing, we recently developed the 52-gene–based Oxford classifier of carcinoma of the ovary (Oxford Classic, OxC) for molecular stratification of serous ovarian cancers (SOCs) based on the molecular profiles of their cell of origin in the fallopian tube epithelium. Here, we developed a 52-gene NanoString panel for the OxC to test the robustness of the classifier. Experimental Design: We measured the expression of the 52 genes in an independent cohort of prospectively colle...
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#1Mohammad KaramiNejadRanjbar (University of Oxford)H-Index: 11
#2Sahand Sharifzadeh (LMU: Ludwig Maximilian University of Munich)H-Index: 5
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 9 authors...
Bulk whole genome sequencing (WGS) enables the analysis of tumor evolution but, because of depth limitations, can only identify old mutational events. The discovery of current mutational processes for predicting the tumor's evolutionary trajectory requires dense sequencing of individual clones or single cells. Such studies, however, are inherently problematic because of the discovery of excessive false positive mutations when sequencing picogram quantities of DNA. Data pooling to increase the co...
3 CitationsSource
#1Mohammad KaramiNejadRanjbar (University of Oxford)H-Index: 11
#2Sahand Sharifzadeh (LMU: Ludwig Maximilian University of Munich)H-Index: 5
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 9 authors...
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#1Gennaro Prota (University of Oxford)H-Index: 4
#2Uzi Gileadi (University of Oxford)H-Index: 28
Last. Vincenzo Cerundolo (University of Oxford)H-Index: 108
view all 17 authors...
Epitopes derived from mutated cancer proteins elicit strong antitumor T-cell responses that correlate with clinical efficacy in a proportion of patients. However, it remains unclear whether the subcellular localization of mutated proteins influences the efficiency of T-cell priming. To address this question we compared the immunogenicity of NY-ESO-1 and OVA localized either in the cytosol or in mitochondria. We showed that tumors expressing mitochondrial-localized NY-ESO-1 and OVA proteins elici...
2 CitationsSource
#1Zhiyuan Hu (University of Oxford)H-Index: 4
#2Mara Artibani (University of Oxford)H-Index: 7
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 27 authors...
Summary The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that NGH in serous ovarian cancer (SOC) can be accurately measured when informed by the molecular signatures of the normal fallopian tube epithelium (FTE) cells, the cells of origin of SOC. Surveying the transcriptomes of ∼6,000 FT...
28 CitationsSource